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Hpse Gene Detail
Summary
  • Symbol
    Hpse
  • Name
    heparanase
  • Synonyms
    Hpa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343124
    NCBI Gene: 15442
  • Gene Overview
    MyGene.info: HPSE
Location & Maps
more
  • Sequence Map
    Chr5:100679484-100719716 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40233 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.51 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HPSE, heparanase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HPSE, heparanase
    Orthology source: HomoloGene
  • Synonyms
    HPA, HPA1, HPR1, HPSE1, HSE1
  • Links
    NCBI Gene ID: 10855
    neXtProt AC: NX_Q9Y251

  • Chr Location
    4q21.3; chr4:83292461-83335153 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68528
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HPSE
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Hpse
  • Incidental Mutations
Mice homozygous for a null allele exhibit precocious mammry gland development, increased angiogenesis and increased neovascularization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026166 VEGA Gene Model | MGI Sequence Detail 40233 C57BL/6J ±  kb
transcript OTTMUST00000064644 VEGA | MGI Sequence Detail 3117 Not Applicable  
polypeptide OTTMUSP00000032126 VEGA | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    185 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 32
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 62
    Developmental Gene Expression 8
    Gene Ontology 9
    Phenotypes 23
  • Earliest
    J:56032 Hulett MD, et al., Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis [see comments]. Nat Med. 1999 Jul;5(7):803-9
  • Latest
    J:231529 Garsen M, et al., Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis. Am J Pathol. 2016 Apr;186(4):805-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory