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Kat2b Gene Detail
Summary
  • Symbol
    Kat2b
  • Name
    K(lysine) acetyltransferase 2B
  • Synonyms
    A930006P13Rik, Pcaf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343094
    NCBI Gene: 18519
  • Gene Overview
    MyGene.info: KAT2B
Location & Maps
more
  • Sequence Map
    Chr17:53566861-53672720 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      105860 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 27.86 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KAT2B, lysine acetyltransferase 2B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KAT2B, lysine acetyltransferase 2B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAF, PCAF, P/CAF
  • Links
    NCBI Gene ID: 8850
    neXtProt AC: NX_Q92831

  • Chr Location
    3p24; chr3:20040032-20154404 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    18 phenotype references
Mice homozygous for a null allele exhibit no abrnomal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035538 VEGA Gene Model | MGI Sequence Detail 105860 C57BL/6J ±  kb
transcript OTTMUST00000091026 VEGA | MGI Sequence Detail 4653 Not Applicable  
polypeptide OTTMUSP00000050078 VEGA | MGI Sequence Detail 813 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    574 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    Genomic 1
    cDNA 82
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2146869, MGI:2147070, MGI:2445128
References
more
  • Summaries
    All 81
    Developmental Gene Expression 16
    Gene Ontology 20
    Phenotypes 18
  • Earliest
    J:57302 Xu W, et al., Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol. 1998 Oct;18(10):5659-69
  • Latest
    J:226885 Tannour-Louet M, et al., Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action. Nat Med. 2014 Jul;20(7):715-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory