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Hdac3
Gene Detail
Symbol

Name
ID
Hdac3
histone deacetylase 3
MGI:1343091
Feature Type
protein coding gene
Genetic Map
Chromosome 18
19.81 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:37935844-37954988 bp, - strand
From VEGA annotation of GRCm38

  19145 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone deacetylase class I, eukaryotic type
Gene Tree: Hdac3

Human
homologs
Human Homolog HDAC3, histone deacetylase 3
NCBI Gene ID 8841
neXtProt AC  NX_O15379
Human Synonyms  HD3, RPD3, RPD3-2
Human Chr (Location)  5q31; chr5:141620876-141636856 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(7) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Disruption of this gene results in embryonic death at or around the time of gastrulation. Structural and functional abnormalities are also reported in mitochondria.
 
Interactions
Hdac3 interacts with 120 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process chromatin modification, circadian regulation of gene expression, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, chromatin DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (95)    Tissues (40)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
Western blot 6
RT-PCR 37
cDNA source data(118)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(1) cDNA(118) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017266 (Evidence)
Ensembl Gene ModelENSMUSG00000024454 (Evidence)
Entrez Gene15183 (Evidence)
UniGene20521
DFCITC1596558, TC1574993, TC1632822
DoTSDT.87068851, DT.110765386, DT.99867439
NIA Mouse Gene IndexU038353
EC3.5.1.98
Consensus CDS ProjectCCDS37785.1
International Mouse Knockout Project StatusHdac3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017266 VEGA Gene Model | MGI Sequence Detail 19145 C57BL/6J ±  kb
transcript OTTMUST00000041787 VEGA | MGI Sequence Detail 2004 Not Applicable 
polypeptide OTTMUSP00000018789 VEGA | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(15)
Polymorphisms
PCR(1) : SNPs within 2kb(180 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003084 Histone deacetylase
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008482 histone deacetylase 3
References
(Earliest) J:56106 Mahlknecht U, et al., Assignment of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization. Cytogenet Cell Genet. 1999;84(3-4):192-3
(Latest) J:210667 Lewandowski SL, et al., Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Hum Mol Genet. 2014 Jul 15;23(14):3801-9
All references(114)
Other
accession IDs
MGI:2147071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory