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Hdac3 Gene Detail
Summary
  • Symbol
    Hdac3
  • Name
    histone deacetylase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343091
    NCBI Gene: 15183
Location & Maps
more
  • Sequence Map
    Chr18:37935844-37954988 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19145 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HDAC3, histone deacetylase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HDAC3, histone deacetylase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HD3, RPD3, RPD3-2
  • Links
    NCBI Gene ID: 8841
    neXtProt AC: NX_O15379

  • Chr Location
    5q31; chr5:141620876-141636856 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 6 alleles in 9 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    7
  • Targeted
    9
  • Incidental Mutations
Disruption of this gene results in embryonic death at or around the time of gastrulation. Structural and functional abnormalities are also reported in mitochondria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017266 VEGA Gene Model | MGI Sequence Detail 19145 C57BL/6J ±  kb
transcript OTTMUST00000041787 VEGA | MGI Sequence Detail 2004 Not Applicable  
polypeptide OTTMUSP00000018789 VEGA | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    180 from dbSNP Build 137
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 123
    Genomic 1
    cDNA 118
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2147071
References
more
  • Summaries
    All 121
    Developmental Gene Expression 21
    Gene Ontology 21
    Phenotypes 40
  • Earliest
    J:56106 Mahlknecht U, et al., Assignment of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization. Cytogenet Cell Genet. 1999;84(3-4):192-3
  • Latest
    J:226173 Keil KP, et al., Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. Dev Dyn. 2015 Nov;244(11):1404-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory