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Klf3
Gene Detail
 Symbol
Name
ID
Klf3
Kruppel-like factor 3 (basic)
MGI:1342773
Synonyms 9930027G08Rik, Bklf, BKLF, Tef-2
Feature Type protein coding gene
Genetic Map
Chromosome 5
33.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:64803523-64830129 bp, + strand
From NCBI annotation of GRCm38

  26607 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Klf3

Human
homologs
Human Homolog KLF3, Kruppel-like factor 3 (basic)
NCBI Gene ID 51274
neXtProt AC  NX_P57682
Human Synonyms  BKLF
Human Chr (Location)  4p14; chr4:38664169-38701508 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(230) : Chemically induced (ENU)(1) Gene trapped(227) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display reduced viability, body size and white adipose tissue. Mice homozygous for a gene trap allele exhibit cardiac defects, reduced body size and abnormal red blood cells. Mice heterozygous for an ENU-induced allele exhibit lethality with heart defects.
 
Interactions
Klf3 interacts with 171 markers (Mir7-1, Mir10a, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (173)    Tissues (110)    Images (10)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 23, 24, 27, 28
Assay TypeResults
RNA in situ 80
RT-PCR 93
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(15) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000029178 (Evidence)
Entrez Gene16599 (Evidence)
DFCITC1578562, TC1602005, TC1613702, TC1620121
DoTSDT.101369847, DT.110681434, DT.530499, DT.87071958, DT.91329134
NIA Mouse Gene IndexU005621, U322728
PDB1P7A, 1U85, 1U86
Consensus CDS ProjectCCDS19301.1
International Mouse Knockout Project StatusKlf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16599 NCBI Gene Model | MGI Sequence Detail 26607 C57BL/6J ±  kb
transcript NM_008453 RefSeq | MGI Sequence Detail 2314 C57BL/6 
polypeptide Q60980 UniProt | EBI | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(185 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009363 krueppel-like factor 3
Graphical View of Protein Domain Structure
References (Earliest) J:31944 Crossley M, et al., Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol Cell Biol. 1996 Apr;16(4):1695-705
(Latest) J:208964 Bell-Anderson KS, et al., Loss of Kruppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2). Diabetes. 2013 Aug;62(8):2728-37
All references(56)
Other
accession IDs
MGD-MRK-35910, MGI:107439, MGI:2141019, MGI:2441767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory