About   Help   FAQ
Klf2
Gene Detail
Symbol

Name
ID
Klf2
Kruppel-like factor 2 (lung)
MGI:1342772
Synonyms
Lklf
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.99 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:72319033-72321656 bp, + strand
From VEGA annotation of GRCm38

  2624 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133978  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee

HCOP human homology predictions: KLF2
Gene Tree: Klf2

Human
homologs
KLF2, Kruppel-like factor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10365
neXtProt AC: NX_Q9Y5W3

Human Synonyms: LKLF

Human Chr (Location): 19p13.11; chr19:16324840-16327534 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
 
Mice homozygous for targeted null mutations die during organogenesis with growth retardation, massive hemorrhage, and signs of anemia. Mice homozygous for one allele also display craniofacial malformations and impaired hematopoiesis. A second allele causes vascular abnormalities.
 
Interactions
Klf2 interacts with 141 markers (Mir16-2, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell morphogenesis, cellular response to laminar fluid shear stress, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (330)    Tissues (177)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 260
Northern blot 18
RT-PCR 52
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KLF2 ; Xenbase klf2 ; ZFIN klf2a, klf2b    NEW 
Molecular
reagents
All nucleic(84) Genomic(3) cDNA(75) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022542 (Evidence)
Ensembl Gene Model ENSMUSG00000055148 (Evidence)
Entrez Gene 16598 (Evidence)
UniGene 26938
DFCI TC1579022
DoTS DT.534366
NIA Mouse Gene Index U105663
Consensus CDS Project CCDS22412.1
International Mouse Phenotyping Consortium Status Klf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022542 VEGA Gene Model | MGI Sequence Detail 2624 C57BL/6J ±  kb
transcript OTTMUST00000053998 VEGA | MGI Sequence Detail 1847 Not Applicable 
polypeptide OTTMUSP00000025717 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009362 krueppel-like factor 2
References
(Earliest) J:29401 Anderson KP, et al., Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. Mol Cell Biol. 1995 Nov;15(11):5957-65
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(95)
Other
accession IDs
MGD-MRK-27042, MGI:104679

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory