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Klf2
Gene Detail
 Symbol
Name
ID
Klf2
Kruppel-like factor 2 (lung)
MGI:1342772
Synonyms Lklf
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.99 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:72319033-72321656 bp, + strand
From VEGA annotation of GRCm38

  2624 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133978  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee

Gene Tree: Klf2

Human
homologs
Human Homolog KLF2, Kruppel-like factor 2
NCBI Gene ID 10365
neXtProt AC  NX_Q9Y5W3
Human Synonyms  LKLF
Human Chr (Location)  19p13.11; chr19:16324840-16327534 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
 
Mice homozygous for targeted null mutations die during organogenesis with growth retardation, massive hemorrhage, and signs of anemia. Mice homozygous for one allele also display craniofacial malformations and impaired hematopoiesis. A second allele causes vascular abnormalities.
 
Interactions
Klf2 interacts with 141 markers (Mir16-2, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell morphogenesis, cellular response to laminar fluid shear stress, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (337)    Tissues (181)    Images (39)
Theiler Stages: 2, 3, 4, 5, 10, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 260
Northern blot 18
RT-PCR 59
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(3) cDNA(75) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022542 (Evidence)
Ensembl Gene ModelENSMUSG00000055148 (Evidence)
Entrez Gene16598 (Evidence)
UniGene26938
DFCITC1579022
DoTSDT.534366
NIA Mouse Gene IndexU105663
Consensus CDS ProjectCCDS22412.1
International Mouse Knockout Project StatusKlf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022542 VEGA Gene Model | MGI Sequence Detail 2624 C57BL/6J ±  kb
transcript OTTMUST00000053998 VEGA | MGI Sequence Detail 1847 Not Applicable 
polypeptide OTTMUSP00000025717 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009362 krueppel-like factor 2
References (Earliest) J:29401 Anderson KP, et al., Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. Mol Cell Biol. 1995 Nov;15(11):5957-65
(Latest) J:206313 Chiplunkar AR, et al., The Kruppel-like factor 2 and Kruppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis. BMC Dev Biol. 2013;13:40
All references(89)
Other
accession IDs
MGD-MRK-27042, MGI:104679

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory