About   Help   FAQ
Klf1 Gene Detail
Summary
  • Symbol
    Klf1
  • Name
    Kruppel-like factor 1 (erythroid)
  • Synonyms
    Eklf, Nan
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342771
    NCBI Gene: 16596
  • Gene Overview
    MyGene.info: KLF1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84901928-84905291 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.30 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342771
protein coding gene Chr8:84901928-84905295 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033878
protein coding gene Chr8:85831721-85835090 (+)
A/J MGP_AJ_G0033861
protein coding gene Chr8:82448435-82451804 (+)
AKR/J MGP_AKRJ_G0033787
protein coding gene Chr8:84891334-84894703 (+)
BALB/cJ MGP_BALBcJ_G0033854
protein coding gene Chr8:82574973-82578342 (+)
C3H/HeJ MGP_C3HHeJ_G0033564
protein coding gene Chr8:85514626-85518634 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034374
protein coding gene Chr8:89110194-89114145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031315
protein coding gene Chr8:76241572-76244743 (+)
CAST/EiJ MGP_CASTEiJ_G0032894
protein coding gene Chr8:84943872-84947246 (+)
CBA/J MGP_CBAJ_G0033540
protein coding gene Chr8:92148981-92152350 (+)
DBA/2J MGP_DBA2J_G0033693
protein coding gene Chr8:82087285-82090654 (+)
FVB/NJ MGP_FVBNJ_G0033641
protein coding gene Chr8:81031074-81034443 (+)
LP/J MGP_LPJ_G0033785
protein coding gene Chr8:85939813-85943182 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033683
protein coding gene Chr8:94706152-94709521 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034391
protein coding gene Chr8:84877164-84882744 (+)
PWK/PhJ MGP_PWKPhJ_G0032598
protein coding gene Chr8:81333560-81336930 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032434
protein coding gene Chr8:83691988-83695371 (+)
WSB/EiJ MGP_WSBEiJ_G0033007
protein coding gene Chr8:85310717-85314086 (+)



Homology
more
  • Human Ortholog
    KLF1, Kruppel like factor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KLF1, Kruppel like factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EKLF, EKLF/KLF1
  • Links
    NCBI Gene ID: 10661
    neXtProt AC: NX_Q13351
    UniProt: Q13351

  • Chr Location
    19p13.13; chr19:12884422-12887203 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Klf1 mouse models; 1 with human KLF1 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit fatal anemia due to impaired hemopoiesis in fetal liver. Homozygotes for an ENU-induced allele die at E10-11 with severely impaired hemopoiesis while surviving heterozygotes show hemolytic anemia with reduced RBC counts, hematocrit and hemoglobin, and altered RBC morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054191 Ensembl Gene Model | MGI Sequence Detail 3364 C57BL/6J ±  kb
    transcript ENSMUST00000067060 Ensembl | MGI Sequence Detail 1530 Not Applicable  
    polypeptide ENSMUSP00000064366 Ensembl | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR031786 Krueppel-like factor 1, transactivation domain 1
      IPR031784 Krueppel-like factor 1, transactivation domain 2
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 7
      cDNA 33
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12777, MGD-MRK-9345, MGI:95311, MGI:97278
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 34
      Diseases 2
      Gene Ontology 13
      Phenotypes 66
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory