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Klf1 Gene Detail
Summary
  • Symbol
    Klf1
  • Name
    Kruppel-like factor 1 (erythroid)
  • Synonyms
    Eklf, Nan
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342771
    NCBI Gene: 16596
  • Gene Overview
    MyGene.info: KLF1
Location & Maps
more
  • Sequence Map
    Chr8:84901928-84905295 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3368 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KLF1, Kruppel-like factor 1 (erythroid)
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KLF1, Kruppel-like factor 1 (erythroid)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDAN4, EKLF, HBFQTL6, INLU
  • Links
    NCBI Gene ID: 10661
    neXtProt AC: NX_Q13351

  • Chr Location
    19p13.2; chr19:12884422-12887203 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Klf1 mouse models; 1 with human KLF1 associations

Human Disease Mouse Models
       Beta-Thalassemia   OMIM: 613985 View 1 model
       Anemia, Congenital Dyserythropoietic, Type IV; CDAN4   OMIM: 613673
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Klf1
  • Incidental Mutations
    APF , CvDC
Nullizygous mice exhibit fatal anemia due to impaired hemopoiesis in fetal liver. Homozygotes for an ENU-induced allele die at E10-11 with severely impaired hemopoiesis while surviving heterozygotes show hemolytic anemia with reduced RBC counts, hematocrit and hemoglobin, and altered RBC morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16596 NCBI Gene Model | MGI Sequence Detail 3368 C57BL/6J ±  kb
transcript NM_010635 RefSeq | MGI Sequence Detail 1534 C57BL/6  
polypeptide P46099 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009353 krueppel-like factor 1
  • InterPro Domains
    IPR031786 Krueppel-like factor 1, transactivation domain 1
    IPR031784 Krueppel-like factor 1, transactivation domain 2
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 47
    Genomic 6
    cDNA 33
    Primer pair 7
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12777, MGD-MRK-9345, MGI:95311, MGI:97278
References
more
  • Summaries
    All 102
    Developmental Gene Expression 31
    Diseases 1
    Gene Ontology 10
    Phenotypes 61
  • Earliest
    J:13933 Lyon MF, et al., Dominant haemolytic anemia. Mouse News Lett. 1983;68:68
  • Latest
    J:228214 Lohmann F, et al., The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells. Mol Cell Biol. 2015 Nov;35(21):3726-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory