Klf1
Gene Detail

Symbol Name ID

Klf1 Kruppel-like factor 1 (erythroid) MGI:1342771

Synonyms

Eklf, Nan

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:84901928-84905295 bp, + strand From NCBI annotation of GRCm38   3368 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Klf1

Human homologs

Human Homolog		KLF1, Kruppel-like factor 1 (erythroid)
NCBI Gene ID		10661
neXtProt AC		NX_Q13351
Human Synonyms		EKLF, HBFQTL6, INLU
Human Chr (Location)		19p13.2; chr19:12995236-12998017 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KLF1

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(11) Chemically induced(1)
 

Nullizygous mice exhibit fatal anemia due to impaired hemopoiesis in fetal liver. Homozygotes for an ENU-induced allele die at E10-11 with severely impaired hemopoiesis while surviving heterozygotes show hemolytic anemia with reduced RBC counts, hematocrit and hemoglobin, and altered RBC morphology.

 
Human Diseases Modeled Using Mouse Klf1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	chromatin remodeling, embryonic hemopoiesis, ...
Component	nuclear chromatin, nucleus
Function	activating transcription factor binding, core promoter proximal region sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (108)    Tissues (46)    Images (11)
Theiler Stages: 2, 3, 10, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	31
Northern blot	15
Western blot	7
RT-PCR	55

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(6) cDNA(33) Primer pair(7) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000054191 (Evidence)
Entrez Gene	16596 (Evidence)
UniGene	4847
DFCI	TC1580465
DoTS	DT.533967
NIA Mouse Gene Index	U088097
Consensus CDS Project	CCDS22483.1
International Mouse Knockout Project Status	Klf1

Sequences

Length	Strain/Species
genomic	16596	NCBI Gene Model | MGI Sequence Detail	3368	C57BL/6J
transcript	NM_010635	RefSeq | MGI Sequence Detail	1534	C57BL/6
polypeptide	P46099	UniProt | EBI | MGI Sequence Detail	358	Not Applicable

All sequences(18) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000009353	krueppel-like factor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:13933 Lyon MF, et al., Dominant haemolytic anemia. Mouse News Lett. 1983;68:68
(Latest) J:192660 Tallack MR, et al., Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Res. 2012 Dec;22(12):2385-98
All references(99)

Other accession IDs

MGD-MRK-12777, MGD-MRK-9345, MGI:95311, MGI:97278