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Klf1
Gene Detail
Symbol

Name
ID
Klf1
Kruppel-like factor 1 (erythroid)
MGI:1342771
Synonyms
Eklf, Nan
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:84901928-84905295 bp, + strand
From NCBI annotation of GRCm38

  3368 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Klf1

Human
homologs
Human Homolog KLF1, Kruppel-like factor 1 (erythroid)
NCBI Gene ID 10661
neXtProt AC  NX_Q13351
Human Synonyms  CDAN4, EKLF, HBFQTL6, INLU
Human Chr (Location)  19p13.2; chr19:12884422-12887203 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KLF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Gene trapped(11) Targeted(4)
Incidental mutations (data from APF )
 
Nullizygous mice exhibit fatal anemia due to impaired hemopoiesis in fetal liver. Homozygotes for an ENU-induced allele die at E10-11 with severely impaired hemopoiesis while surviving heterozygotes show hemolytic anemia with reduced RBC counts, hematocrit and hemoglobin, and altered RBC morphology.
 
Human Diseases Modeled Using Mouse Klf1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Klf1 interacts with 38 markers (Mir29b-2, Mir125a, Mir125b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (28 records)
Data Summary: Results (108)    Tissues (46)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
Northern blot 15
Western blot 7
RT-PCR 55
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(6) cDNA(33) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000054191 (Evidence)
Entrez Gene16596 (Evidence)
UniGene4847
DFCITC1580465
DoTSDT.533967
NIA Mouse Gene IndexU088097
Consensus CDS ProjectCCDS22483.1
International Mouse Knockout Project StatusKlf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16596 NCBI Gene Model | MGI Sequence Detail 3368 C57BL/6J ±  kb
transcript NM_010635 RefSeq | MGI Sequence Detail 1534 C57BL/6 
polypeptide P46099 UniProt | EBI | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009353 krueppel-like factor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:13933 Lyon MF, et al., Dominant haemolytic anemia. Mouse News Lett. 1983;68:68
(Latest) J:204029 Liu S, et al., Erythropoiesis in the absence of adult hemoglobin. Mol Cell Biol. 2013 Jun;33(11):2241-51
All references(102)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12777, MGD-MRK-9345, MGI:95311, MGI:97278

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory