Phenotypes Associated with This Genotype

Genotype
MGI:4819280

• Allelic Composition: Klf1^Nan/Klf1⁺
• Genetic Background: either: B6.Cg-Klf1^Nan or WB.Cg-Klf1^Nan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased spleen weight ( J:162530 )

• spleens weigh 2X those of controls

mortality/aging

postnatal lethality, incomplete penetrance ( J:162530 )

• significant numbers die before weaning

hematopoietic system

increased spleen weight ( J:162530 )

• spleens weigh 2X those of controls

abnormal erythrocyte morphology ( J:162530 )

• elevated enzyme activity

decreased erythrocyte cell number ( J:162530 )

decreased hematocrit ( J:162530 )

• substantially decreased

decreased hemoglobin content ( J:162530 )

• substantially decreased

decreased mean corpuscular hemoglobin ( J:162530 )

• hypochromia

anisocytosis ( J:162530 )

poikilocytosis ( J:162530 )

polychromatophilia ( J:162530 )

increased erythrocyte osmotic fragility ( J:162530 )

• susceptible to hemolysis

• cell membranes more fragile

immune system

increased spleen weight ( J:162530 )

• spleens weigh 2X those of controls

integument

pallor ( J:162530 )

• at birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spherocytosis		DOID:12971		J:162530