Rlim
Gene Detail

Symbol Name ID

Rlim ring finger protein, LIM domain interacting MGI:1342291

Synonyms

Ha1r, Rnf12

Feature Type

protein coding gene

Genetic Map

Chromosome X

46.42 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:103957163-103981284 bp, - strand From VEGA annotation of GRCm38   24122 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7920  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rlim

Human homologs

Human Homolog		RLIM, ring finger protein, LIM domain interacting
NCBI Gene ID		51132
neXtProt AC		NX_Q9NVW2
Human Synonyms		NY-REN-43, RNF12
Human Chr (Location)		Xq13-q21; chrX:73802811-73834461 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(20) : Targeted(6) Gene trapped(14)
 

Mice heterozygous for a knock-out allele exhibit female-specific embryonic lethality when the allele is inherited maternally due to disruption in X-inactivation.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of transcription from RNA polymerase II promoter, ...
Component	cytoplasm, nucleus
Function	ligase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (38)    Tissues (38)    Images (4)
Theiler Stages: 16, 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	32
Northern blot	6

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(22)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000018399 (Evidence)
Ensembl Gene Model	ENSMUSG00000056537 (Evidence)
Entrez Gene	19820 (Evidence)
DFCI	TC1574693, TC1578325, TC1658266, TC1679755, TC1742235
DoTS	DT.101214617, DT.533104
NIA Mouse Gene Index	U039604
EC	6.3.2.-
Consensus CDS Project	CCDS30331.1
International Mouse Knockout Project Status	Rlim

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018399	VEGA Gene Model | MGI Sequence Detail	24122	C57BL/6J
transcript	OTTMUST00000044404	VEGA | MGI Sequence Detail	7439	Not Applicable
polypeptide	OTTMUSP00000019950	VEGA | MGI Sequence Detail	600	Not Applicable

All sequences(58) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000014073	E3 ubiquitin-protein ligase RNF12

References

(Earliest) J:56497 Bach I, et al., RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug;22(4):394-9
(Latest) J:185555 Mugford JW, et al., Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. Development. 2012 Jun;139(12):2130-8
All references(52)

Other accession IDs

MGI:1353615, MGI:2147943, MGI:2148028