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Rlim Gene Detail
Summary
  • Symbol
    Rlim
  • Name
    ring finger protein, LIM domain interacting
  • Synonyms
    Ha1r, Rlim1, Rnf12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342291
    NCBI Gene: 19820
  • Gene Overview
    MyGene.info: RLIM
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:103957163-103981284 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 46.42 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342291
protein coding gene ChrX:103957163-103981296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035988
protein coding gene ChrX:100648102-100671785 (-)
A/J MGP_AJ_G0035969
protein coding gene ChrX:100544388-100571023 (-)
AKR/J MGP_AKRJ_G0035887
protein coding gene ChrX:103623644-103647664 (-)
BALB/cJ MGP_BALBcJ_G0035959
protein coding gene ChrX:99342815-99367310 (-)
C3H/HeJ MGP_C3HHeJ_G0035665
protein coding gene ChrX:101101318-101129468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036485
protein coding gene ChrX:103598390-103623035 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033313
protein coding gene ChrX:98180882-98184302 (-)
CAST/EiJ MGP_CASTEiJ_G0034951
protein coding gene ChrX:85361711-85385888 (-)
CBA/J MGP_CBAJ_G0035640
protein coding gene ChrX:106810924-106837095 (-)
DBA/2J MGP_DBA2J_G0035794
protein coding gene ChrX:99790935-99815104 (-)
FVB/NJ MGP_FVBNJ_G0035735
protein coding gene ChrX:99097753-99121246 (-)
LP/J MGP_LPJ_G0035887
protein coding gene ChrX:101642022-101666101 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035767
protein coding gene ChrX:111466520-111493092 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036511
protein coding gene ChrX:100324090-100351433 (-)
PWK/PhJ MGP_PWKPhJ_G0034649
protein coding gene ChrX:82936986-82961008 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034477
protein coding gene ChrX:86074887-86098556 (-)
WSB/EiJ MGP_WSBEiJ_G0035091
protein coding gene ChrX:99049344-99082093 (-)



Homology
more
  • Human Ortholog
    RLIM, ring finger protein, LIM domain interacting
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RLIM, ring finger protein, LIM domain interacting
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRX61, NY-REN-43, RNF12, TOKAS
  • Links
    NCBI Gene ID: 51132
    neXtProt AC: NX_Q9NVW2
    UniProt: Q9NVW2

  • Chr Location
    Xq13.2; chrX:74582976-74614626 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7920
    1 human;1 mouse;2 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RLIM
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit female-specific embryonic lethality when the allele is inherited maternally due to disruption in X-inactivation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056537 Ensembl Gene Model | MGI Sequence Detail 24122 C57BL/6J ±  kb
transcript ENSMUST00000121153 Ensembl | MGI Sequence Detail 7439 Not Applicable  
polypeptide ENSMUSP00000112820 Ensembl | MGI Sequence Detail 600 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 23

    Microarray probesets 9
Other
Accession IDs
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MGI:1353615, MGI:2147943, MGI:2148028
References
more
  • Summaries
    All 61
    Developmental Gene Expression 16
    Gene Ontology 11
    Phenotypes 14
  • Earliest
    J:56497 Bach I, et al., RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug;22(4):394-9
  • Latest
    J:263985 de Melo J, et al., Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina. Development. 2018 Apr 30;145(9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory