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Rlim Gene Detail
Summary
  • Symbol
    Rlim
  • Name
    ring finger protein, LIM domain interacting
  • Synonyms
    Ha1r, Rlim1, Rnf12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342291
    NCBI Gene: 19820
  • Gene Overview
    MyGene.info: RLIM
Location & Maps
more
  • Sequence Map
    ChrX:103957163-103981284 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24122 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RLIM, ring finger protein, LIM domain interacting
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RLIM, ring finger protein, LIM domain interacting
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NY-REN-43, RNF12
  • Links
    NCBI Gene ID: 51132
    neXtProt AC: NX_Q9NVW2

  • Chr Location
    Xq13-q21; chrX:74582976-74614626 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7920
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RLIM
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    14
  • Targeted
    6
Mice heterozygous for a knock-out allele exhibit female-specific embryonic lethality when the allele is inherited maternally due to disruption in X-inactivation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018399 VEGA Gene Model | MGI Sequence Detail 24122 C57BL/6J ±  kb
transcript OTTMUST00000044404 VEGA | MGI Sequence Detail 7439 Not Applicable  
polypeptide OTTMUSP00000019950 VEGA | MGI Sequence Detail 600 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 23
    Genomic 1
    cDNA 22

    Microarray probesets 9
Other
Accession IDs
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MGI:1353615, MGI:2147943, MGI:2148028
References
more
  • Summaries
    All 55
    Developmental Gene Expression 14
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:56497 Bach I, et al., RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug;22(4):394-9
  • Latest
    J:226026 Deuve JL, et al., Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome. Epigenetics. 2015 Oct 3;10(10):931-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory