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Rlim
Gene Detail
Symbol

Name
ID
Rlim
ring finger protein, LIM domain interacting
MGI:1342291
Synonyms
Ha1r, Rlim1, Rnf12
Feature Type
protein coding gene
Genetic Map
Chromosome X
46.42 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:103957163-103981284 bp, - strand
From VEGA annotation of GRCm38

  24122 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7920  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RLIM
Gene Tree: Rlim

Human
homologs
RLIM, ring finger protein, LIM domain interacting
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51132
neXtProt AC: NX_Q9NVW2

Human Synonyms: NY-REN-43, RNF12

Human Chr (Location): Xq13-q21; chrX:74582976-74614626 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(14) Targeted(6)
 
Mice heterozygous for a knock-out allele exhibit female-specific embryonic lethality when the allele is inherited maternally due to disruption in X-inactivation.
 
Phenotype Images(1)
Interactions
Rlim interacts with 493 markers (Mir1b, Mir7-1, Mir7-2, ...)
Expression
Literature Summary: (13 records)
Data Summary: Results (38)    Tissues (38)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 32
Northern blot 6
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rlim ; ZFIN rlim    NEW 
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(22)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000018399 (Evidence)
Ensembl Gene Model ENSMUSG00000056537 (Evidence)
Entrez Gene 19820 (Evidence)
DFCI TC1742235, TC1578325, TC1574693, TC1679755, TC1658266
DoTS DT.533104, DT.101214617
NIA Mouse Gene Index U039604
EC 6.3.2.-
Consensus CDS Project CCDS30331.1
International Mouse Phenotyping Consortium Status Rlim
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018399 VEGA Gene Model | MGI Sequence Detail 24122 C57BL/6J ±  kb
transcript OTTMUST00000044404 VEGA | MGI Sequence Detail 7439 Not Applicable 
polypeptide OTTMUSP00000019950 VEGA | MGI Sequence Detail 600 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(14) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000014073 E3 ubiquitin-protein ligase RLIM
References
(Earliest) J:56497 Bach I, et al., RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug;22(4):394-9
(Latest) J:213272 Shin J, et al., RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature. 2014 Jul 3;511(7507):86-9
All references(56)
Other
accession IDs
MGI:1353615, MGI:2147943, MGI:2148028

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory