Sequence Detail

ID/Version

Q9WTV7 Q9CYY2 Q91X19 Q8CE02 (UniProt | EBI)

Last sequence update: 2009-09-22
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase RLIM {ECO:0000250|UniProtKB:Q9NVW2}; EC=2.3.2.27 {ECO:0000250|UniProtKB:Q9NVW2};AltName: Full=LIM domain-interacting RING finger protein {ECO:0000250|UniProtKB:Q9NVW2};AltName: Full=RING finger LIM domain-

Provider

SWISS-PROT

Sequence

Polypeptide 600 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rlim	ring finger protein, LIM domain interacting	54	106	3	23

Sequence references in MGI

J:56497 Bach I, et al., RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug;22(4):394-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101335 Tursun B, et al., The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 2005 Oct 1;19(19):2307-19
J:156024 Jonkers I, et al., RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation. Cell. 2009 Nov 25;139(5):999-1011
J:161034 Ostendorff HP, et al., Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature. 2002 Mar 7;416(6876):99-103
J:184207 Gontan C, et al., RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. Nature. 2012 May 17;485(7398):386-90
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:366952 Bustos F, et al., RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation. Cell Rep. 2018 May 8;23(6):1599-1611