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Ly96
Gene Detail
 Symbol
Name
ID
Ly96
lymphocyte antigen 96
MGI:1341909
Synonyms ESOP-1, MD2, MD-2, myeloid differentiation factor-2
Feature Type protein coding gene
Genetic Map
Chromosome 1
5.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:16688051-16709611 bp, + strand
From VEGA annotation of GRCm38

  21561 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ly96

Human
homologs
Human Homolog LY96, lymphocyte antigen 96
NCBI Gene ID 23643
neXtProt AC  NX_Q9Y6Y9
Human Synonyms  ESOP-1, ly-96, MD2, MD-2
Human Chr (Location)  8q21.11; chr8:73991329-74029079 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired responsiveness to LPS, are resistant to LPS-induced lethal toxicity but show increased susceptibility to Salmonella typhimurium infection.
 
Interactions
Ly96 interacts with 57 markers (Mir196a-2, Mir208a, Mir297a-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process detection of lipopolysaccharide, immune system process, ...
Component extracellular region, lipopolysaccharide receptor complex
Function lipopolysaccharide receptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (35)   
Theiler Stages: 11, 13, 14, 19, 20, 21, 23, 28
Assay TypeResults
Immunohistochemistry 18
Northern blot 19
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000048080 (Evidence)
Ensembl Gene ModelENSMUSG00000025779 (Evidence)
Entrez Gene17087 (Evidence)
UniGene116844
DFCITC1591354, TC1714460
DoTSDT.103547672, DT.91325593, DT.94293510
NIA Mouse Gene IndexU000074
PDB2Z64, 3VQ1, 3VQ2
Consensus CDS ProjectCCDS14832.1
International Mouse Knockout Project StatusLy96
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048080 VEGA Gene Model | MGI Sequence Detail 21561 C57BL/6J ±  kb
transcript OTTMUST00000123539 VEGA | MGI Sequence Detail 632 Not Applicable 
polypeptide OTTMUSP00000067435 VEGA | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR003172 MD-2-related lipid-recognition (ML) domain
Protein Ontology PR:000003296 lymphocyte antigen 96
References (Earliest) J:55323 Shimazu R, et al., MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med. 1999 Jun 7;189(11):1777-82
(Latest) J:205686 Deguchi A, et al., Serum amyloid A3 binds MD-2 to activate p38 and NF-kappaB pathways in a MyD88-dependent manner. J Immunol. 2013 Aug 15;191(4):1856-64
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory