About   Help   FAQ
Ly96
Gene Detail
Symbol

Name
ID
Ly96
lymphocyte antigen 96
MGI:1341909
Synonyms
ESOP-1, MD2, MD-2, myeloid differentiation factor-2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
5.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:16688051-16709611 bp, + strand
From VEGA annotation of GRCm38

  21561 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: LY96
Gene Tree: Ly96

Human
homologs
LY96, lymphocyte antigen 96
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23643
neXtProt AC: NX_Q9Y6Y9

Human Synonyms: ESOP-1, ly-96, MD2, MD-2

Human Chr (Location): 8q21.11; chr8:73991329-74032562 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired responsiveness to LPS, are resistant to LPS-induced lethal toxicity but show increased susceptibility to Salmonella typhimurium infection.
 
Interactions
Ly96 interacts with 57 markers (Mir196a-2, Mir208a, Mir297a-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
Northern blot 19
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000048080 (Evidence)
Ensembl Gene Model ENSMUSG00000025779 (Evidence)
Entrez Gene 17087 (Evidence)
UniGene 116844
DFCI TC1591354, TC1714460
DoTS DT.103547672, DT.91325593, DT.94293510
NIA Mouse Gene Index U000074
PDB 2Z64, 3VQ1, 3VQ2
Consensus CDS Project CCDS14832.1, CCDS78550.1
International Mouse Phenotyping Consortium Status Ly96
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048080 VEGA Gene Model | MGI Sequence Detail 21561 C57BL/6J ±  kb
transcript OTTMUST00000123539 VEGA | MGI Sequence Detail 632 Not Applicable 
polypeptide OTTMUSP00000067435 VEGA | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR003172 MD-2-related lipid-recognition domain
Protein Ontology PR:000003296 lymphocyte antigen 96
References
(Earliest) J:61404 Akashi S, et al., Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol. 2000 Apr 1;164(7):3471-5
(Latest) J:222669 Tanimura N, et al., The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014 Jun;26(6):307-14
All references(73)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory