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Ly96 Gene Detail
Summary
  • Symbol
    Ly96
  • Name
    lymphocyte antigen 96
  • Synonyms
    ESOP-1, MD2, MD-2, myeloid differentiation factor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341909
    NCBI Gene: 17087
  • Gene Overview
    MyGene.info: LY96
Location & Maps
more
  • Sequence Map
    Chr1:16688051-16709611 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21561 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 5.10 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LY96, lymphocyte antigen 96
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LY96, lymphocyte antigen 96
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ESOP-1, ly-96, MD2, MD-2
  • Links
    NCBI Gene ID: 23643
    neXtProt AC: NX_Q9Y6Y9

  • Chr Location
    8q21.11; chr8:73991329-74032562 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired responsiveness to LPS, are resistant to LPS-induced lethal toxicity but show increased susceptibility to Salmonella typhimurium infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048080 VEGA Gene Model | MGI Sequence Detail 21561 C57BL/6J ±  kb
transcript OTTMUST00000123539 VEGA | MGI Sequence Detail 632 Not Applicable  
polypeptide OTTMUSP00000067435 VEGA | MGI Sequence Detail 160 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    234 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 72
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:61404 Akashi S, et al., Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol. 2000 Apr 1;164(7):3471-5
  • Latest
    J:220097 Riquelme SA, et al., Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility. Immunology. 2015 Feb;144(2):321-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory