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Hhip
Gene Detail
Symbol

Name
ID
Hhip
Hedgehog-interacting protein
MGI:1341847
Synonyms
Hhip1, Hip, Hip1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
37.95 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:79966115-80058006 bp, - strand
From VEGA annotation of GRCm38

  91892 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32469  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hhip

Human
homologs
Human Homolog HHIP, hedgehog interacting protein
NCBI Gene ID 64399
neXtProt AC  NX_Q96QV1
Human Synonyms  HIP
Human Chr (Location)  4q28-q32; chr4:144645996-144741391 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele die shortly after birth due to respiratory failure, show defects in lung, spleen and pancreas morphogenesis, and exhibit small and disorganized pancreatic islets and reduced beta-cell proliferation.
 
Interactions
Hhip interacts with 360 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process carbohydrate metabolic process, dorsal/ventral pattern formation, ...
Component cell surface, extracellular region, ...
Function catalytic activity, hedgehog family protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (322)    Tissues (90)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 242
In situ reporter (knock in) 14
RT-PCR 66
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(20) Primer pair(4) Other(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000031006 (Evidence)
Ensembl Gene ModelENSMUSG00000064325 (Evidence)
Entrez Gene15245 (Evidence)
UniGene254493
DFCITC1586105, TC1601104
DoTSDT.60104243
NIA Mouse Gene IndexU029997, U255752
Consensus CDS ProjectCCDS22440.1
International Mouse Knockout Project StatusHhip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031006 VEGA Gene Model | MGI Sequence Detail 91892 C57BL/6J ±  kb
transcript OTTMUST00000076798 VEGA | MGI Sequence Detail 4582 Not Applicable 
polypeptide OTTMUSP00000040485 VEGA | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(408 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR018143 Folate receptor-like
InterPro IPR012938 Glucose/Sorbosone dehydrogenase
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase
Protein Ontology PR:000008541 hedgehog-interacting protein
References
(Earliest) J:53760 Chuang PT, et al., Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. 1999 Feb 18;397(6720):617-21
(Latest) J:202828 Regard JB, et al., Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med. 2013 Nov;19(11):1505-12
All references(75)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory