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Hhip Gene Detail
Summary
  • Symbol
    Hhip
  • Name
    Hedgehog-interacting protein
  • Synonyms
    Hhip1, Hip, Hip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341847
    NCBI Gene: 15245
  • Gene Overview
    MyGene.info: HHIP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:79965851-80058006 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92156 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 37.95 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HHIP, hedgehog interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HHIP, hedgehog interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HIP
  • Links
    NCBI Gene ID: 64399
    neXtProt AC: NX_Q96QV1
    UniProt: Q96QV1

  • Chr Location
    4q31.21; chr4:144645996-144742645 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32469
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HHIP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele die shortly after birth due to respiratory failure, show defects in lung, spleen and pancreas morphogenesis, and exhibit small and disorganized pancreatic islets and reduced beta-cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031006 VEGA Gene Model | MGI Sequence Detail 92156 C57BL/6J ±  kb
    transcript OTTMUST00000076798 VEGA | MGI Sequence Detail 9074 Not Applicable  
    polypeptide OTTMUSP00000040485 VEGA | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      409 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 21
      Primer pair 6
      Other 4

      Microarray probesets 7
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 65
      Gene Ontology 10
      Phenotypes 40
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:251890 Xiao X, et al., Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. Mol Cell. 2017 Apr 6;66(1):154-162.e10

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory