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Six6
Gene Detail
Symbol

Name
ID
Six6
sine oculis-related homeobox 6
MGI:1341840
Synonyms
Optx2, Six9
Feature Type
protein coding gene
Genetic Map
Chromosome 12
30.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:72939892-72944899 bp, + strand
From VEGA annotation of GRCm38

  5008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SIX6
Gene Tree: Six6

Human
homologs
SIX6, SIX homeobox 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4990
neXtProt AC: NX_O95475

Human Synonyms: MCOPCT2, ODRMD, OPTX2, Six9

Human Chr (Location): 14q23.1; chr14:60509220-60511807 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SIX6

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display retinal and pituitary hypoplasia.
 
Interactions
Six6 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process multicellular organismal development, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (335)    Tissues (199)    Images (75)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 304
Northern blot 1
RT-PCR 30
cDNA source data(28)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase six6 ; ZFIN six6b    NEW 
Molecular
reagents
All nucleic(32) cDNA(29) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000040057 (Evidence)
Ensembl Gene Model ENSMUSG00000021099 (Evidence)
Entrez Gene 20476 (Evidence)
UniGene 57138
DFCI TC1584688
NIA Mouse Gene Index U014070
Consensus CDS Project CCDS25972.1
International Mouse Phenotyping Consortium Status Six6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040057 VEGA Gene Model | MGI Sequence Detail 5008 C57BL/6J ±  kb
transcript OTTMUST00000104016 VEGA | MGI Sequence Detail 4009 Not Applicable 
polypeptide OTTMUSP00000058165 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014901 homeobox protein SIX6
References
(Earliest) J:55598 Toy J, et al., The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10643-8
(Latest) J:218295 Mortensen AH, et al., Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
All references(67)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory