Six6
Gene Detail

Symbol Name ID

Six6 sine oculis-related homeobox 6 MGI:1341840

Synonyms

Optx2, Six9

Feature Type

protein coding gene

Genetic Map

Chromosome 12

30.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:72939724-72946094 bp, + strand From VEGA annotation of GRCm38   6371 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Six6

Human homologs

Human Homolog		SIX6, SIX homeobox 6
NCBI Gene ID		4990
neXtProt AC		NX_O95475
Human Synonyms		MCOPCT2, OPTX2, Six9
Human Chr (Location)		14q23.1; chr14:60975938-60978525 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SIX6

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene display retinal and pituitary hypoplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	multicellular organismal development, regulation of transcription, DNA-dependent
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (35 records)
Data Summary: Results (232)    Tissues (128)    Images (60)
Theiler Stages: 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	223
Northern blot	1
RT-PCR	8

cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(30) cDNA(28) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000040057 (Evidence)
Ensembl Gene Model	ENSMUSG00000021099 (Evidence)
Entrez Gene	20476 (Evidence)
UniGene	57138
DFCI	TC1584688
NIA Mouse Gene Index	U014070
Consensus CDS Project	CCDS25972.1
International Mouse Knockout Project Status	Six6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040057	VEGA Gene Model | MGI Sequence Detail	6371	C57BL/6J
transcript	OTTMUST00000104016	VEGA | MGI Sequence Detail	5372	Not Applicable
polypeptide	OTTMUSP00000058165	VEGA | MGI Sequence Detail	246	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000014901	homeobox protein SIX6

References

(Earliest) J:55598 Toy J, et al., The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10643-8
(Latest) J:193195 Katoh K, et al., G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. J Neurosci. 2012 Dec 5;32(49):17658-70
All references(64)