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Six6
Gene Detail
Symbol

Name
ID
Six6
sine oculis-related homeobox 6
MGI:1341840
Synonyms
Optx2, Six9
Feature Type
protein coding gene
Genetic Map
Chromosome 12
30.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:72939892-72944899 bp, + strand
From VEGA annotation of GRCm38

  5008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Six6

Human
homologs
Human Homolog SIX6, SIX homeobox 6
NCBI Gene ID 4990
neXtProt AC  NX_O95475
Human Synonyms  MCOPCT2, OPTX2, Six9
Human Chr (Location)  14q23.1; chr14:60509220-60511807 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SIX6
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display retinal and pituitary hypoplasia.
 
Interactions
Six6 interacts with 354 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process multicellular organismal development, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (335)    Tissues (199)    Images (75)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 304
Northern blot 1
RT-PCR 30
cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(29) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000040057 (Evidence)
Ensembl Gene ModelENSMUSG00000021099 (Evidence)
Entrez Gene20476 (Evidence)
UniGene57138
DFCITC1584688
NIA Mouse Gene IndexU014070
Consensus CDS ProjectCCDS25972.1
International Mouse Knockout Project StatusSix6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040057 VEGA Gene Model | MGI Sequence Detail 5008 C57BL/6J ±  kb
transcript OTTMUST00000104016 VEGA | MGI Sequence Detail 4009 Not Applicable 
polypeptide OTTMUSP00000058165 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014901 homeobox protein SIX6
References
(Earliest) J:55598 Toy J, et al., The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10643-8
(Latest) J:206224 Dixit R, et al., Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
All references(68)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory