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Six6 Gene Detail
Summary
  • Symbol
    Six6
  • Name
    sine oculis-related homeobox 6
  • Synonyms
    Optx2, Six9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341840
    NCBI Gene: 20476
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:72939892-72944899 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341840
protein coding gene Chr12:72939882-72944899 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019831
protein coding gene Chr12:72807171-72812182 (+)
A/J MGP_AJ_G0019789
protein coding gene Chr12:70097916-70102914 (+)
AKR/J MGP_AKRJ_G0019764
protein coding gene Chr12:72217777-72222784 (+)
BALB/cJ MGP_BALBcJ_G0019769
protein coding gene Chr12:70573174-70578172 (+)
C3H/HeJ MGP_C3HHeJ_G0019574
protein coding gene Chr12:72645966-72650964 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020221
protein coding gene Chr12:75078098-75083105 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017839
protein coding gene Chr12:67552226-67557227 (+)
CAST/EiJ MGP_CASTEiJ_G0019126
protein coding gene Chr12:67434953-67439956 (+)
CBA/J MGP_CBAJ_G0019544
protein coding gene Chr12:77918150-77923148 (+)
DBA/2J MGP_DBA2J_G0019660
protein coding gene Chr12:69982857-69987864 (+)
FVB/NJ MGP_FVBNJ_G0019647
protein coding gene Chr12:68843358-68848365 (+)
LP/J MGP_LPJ_G0019732
protein coding gene Chr12:72836424-72841431 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019686
protein coding gene Chr12:81092373-81097368 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020256
protein coding gene Chr12:71693861-71698868 (+)
PWK/PhJ MGP_PWKPhJ_G0018891
protein coding gene Chr12:64294299-64299322 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018686
protein coding gene Chr12:66108058-66113059 (+)
WSB/EiJ MGP_WSBEiJ_G0019177
protein coding gene Chr12:72290791-72295798 (+)



Homology
more
  • Human Ortholog
    SIX6, SIX homeobox 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIX6, SIX homeobox 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCOPCT2, ODRMD, OPTX2, Six9
  • Links
    NCBI Gene ID: 4990
    neXtProt AC: NX_O95475
    UniProt: O95475

  • Chr Location
    14q23.1; chr14:60509220-60511807 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7220
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIX6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SIX6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display retinal and pituitary hypoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021099 Ensembl Gene Model | MGI Sequence Detail 5008 C57BL/6J ±  kb
    transcript ENSMUST00000021519 Ensembl | MGI Sequence Detail 4009 Not Applicable  
    polypeptide ENSMUSP00000021519 Ensembl | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 30
      Primer pair 4
      Other 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 48
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:55598 Toy J, et al., The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10643-8
    • Latest
      J:246467 Liu W, et al., Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice. Dev Biol. 2017 Aug 01;428(1):164-175

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory