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Fanca
Gene Detail
 Symbol
Name
ID
Fanca
Fanconi anemia, complementation group A
MGI:1341823
Feature Type protein coding gene
Genetic Map
Chromosome 8
72.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:123268300-123318576 bp, - strand
From VEGA annotation of GRCm38

  50277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:108  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fanca

Human
homologs
Human Homolog FANCA, Fanconi anemia, complementation group A
NCBI Gene ID 2175
neXtProt AC  NX_O15360
Human Synonyms  FA, FA1, FAA, FACA, FAH, FA-H, FANCH
Human Chr (Location)  16q24.3; chr16:89737551-89816658 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FANCA
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants show variably: growth retardation, microphthalmia, craniofacial malformations and hematological changes, depending on allele and strain background. Both sexes show hypogonadism, including diminished primordial germ cells and impaired fertility.
 
Human Diseases Modeled Using Mouse Fanca (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Fanca interacts with 244 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, Fanconi anaemia nuclear complex, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (29)    Tissues (23)    Images (1)
Theiler Stages: 10, 18, 19, 22, 23, 24, 25, 28
Assay TypeResults
Northern blot 13
RT-PCR 16
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030114 (Evidence)
Ensembl Gene ModelENSMUSG00000032815 (Evidence)
Entrez Gene14087 (Evidence)
NIA Mouse Gene IndexU030374, U274576
Consensus CDS ProjectCCDS22753.1
International Mouse Knockout Project StatusFanca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030114 VEGA Gene Model | MGI Sequence Detail 50277 C57BL/6J ±  kb
transcript OTTMUST00000074594 VEGA | MGI Sequence Detail 4485 Not Applicable 
polypeptide OTTMUSP00000038918 VEGA | MGI Sequence Detail 1439 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(15) UniProt(7)
Polymorphisms SNPs within 2kb(665 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003516 Fanconi anaemia group A protein
Protein Ontology PR:000007330 Fanconi anemia group A protein
References (Earliest) J:56258 Abu-Issa R, et al., Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Blood. 1999 Jul 15;94(2):818-24
(Latest) J:210175 Du W, et al., Deletion of Fanca or Fancd2 dysregulates Treg in mice. Blood. 2014 Mar 20;123(12):1938-47
All references(48)
Disease annotation references (2)
Other
accession IDs
MGI:2142773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory