Eif4h
Gene Detail

Symbol Name ID

Eif4h eukaryotic translation initiation factor 4H MGI:1341822

Synonyms

D5Ertd355e, E430026L18Rik, Eif4h, Wbscr1, Wscr1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

74.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr5:134619876-134639328 bp, - strand From NCBI annotation of GRCm38   19453 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Eif4h

Human homologs

Human Homolog		EIF4H, eukaryotic translation initiation factor 4H
NCBI Gene ID		7458
neXtProt AC		NX_Q15056
Human Synonyms		eIF-4H, WBSCR1, WSCR1
Human Chr (Location)		7q11.23; chr7:73588706-73611429 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(48) : Targeted(2) Gene trapped(46)
 

Mice homozygous for a gene trap allele exhibit growth defects and impaired cognitive behaviors.

 
Human Diseases Modeled Using Mouse Eif4h (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	developmental growth, sexual reproduction, ...
Component	cytoplasm
Function	nucleic acid binding, nucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (59)    Tissues (51)    Images (5)
Theiler Stages: 10, 17, 18, 21, 23, 25, 28

Assay Type	Results
RNA in situ	41
Western blot	6
RT-PCR	12

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(4) cDNA(20) Primer pair(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000040731 (Evidence)
Entrez Gene	22384 (Evidence)
NIA Mouse Gene Index	U026803
PDB	2DNG
Consensus CDS Project	CCDS19723.1
International Mouse Knockout Project Status	Eif4h

Sequences

Length	Strain/Species
genomic	22384	NCBI Gene Model | MGI Sequence Detail	19453	C57BL/6J
transcript	NM_033561	RefSeq | MGI Sequence Detail	2409	129/Sv
polypeptide	Q9WUK2	UniProt | EBI | MGI Sequence Detail	248	Not Applicable

All sequences(74) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(125 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000007001	eukaryotic translation initiation factor 4H

Graphical View of Protein Domain Structure

References

(Earliest) J:55324 DeSilva U, et al., Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. Genome Res. 1999 May;9(5):428-36
(Latest) J:181945 Capossela S, et al., Growth defects and impaired cognitive-behavioral abilities in mice with knockout for Eif4h, a gene located in the mouse homolog of the Williams-Beuren syndrome critical region. Am J Pathol. 2012 Mar;180(3):1121-35
All references(44)

Other accession IDs

MGI:1196428, MGI:2141045, MGI:2444028