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Eif4h
Gene Detail
Symbol

Name
ID
Eif4h
eukaryotic translation initiation factor 4H
MGI:1341822
Synonyms
D5Ertd355e, E430026L18Rik, Eif4h, Wbscr1, Wscr1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
74.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:134619880-134639348 bp, - strand
From Ensembl annotation of GRCm38

  19469 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EIF4H
Gene Tree: Eif4h

Human
homologs
EIF4H, eukaryotic translation initiation factor 4H
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7458
neXtProt AC: NX_Q15056

Human Synonyms: eIF-4H, WBSCR1, WSCR1

Human Chr (Location): 7q11.23; chr7:74174376-74197101 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(46) Targeted(4)
Genomic Mutations involving Eif4h (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit growth defects and impaired cognitive behaviors.
 
Human Diseases Modeled in Mice Using Eif4h (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Eif4h interacts with 209 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process developmental growth, sexual reproduction, ...
Component cytoplasm, membrane
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (59)    Tissues (51)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
Western blot 6
RT-PCR 12
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EIF4H ; Xenbase eif4h ; ZFIN eif4h    NEW 
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(20) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000040731 (Evidence)
Entrez Gene 22384 (Evidence)
NIA Mouse Gene Index U026803
PDB 2DNG
Consensus CDS Project CCDS19723.1
International Mouse Phenotyping Consortium Status Eif4h
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040731 Ensembl Gene Model | MGI Sequence Detail 19469 C57BL/6J ±  kb
transcript ENSMUST00000036125 Ensembl | MGI Sequence Detail 2425 Not Applicable 
polypeptide ENSMUSP00000048833 Ensembl | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(4) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000007001 eukaryotic translation initiation factor 4H
References
(Earliest) J:55324 DeSilva U, et al., Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. Genome Res. 1999 May;9(5):428-36
(Latest) J:181945 Capossela S, et al., Growth defects and impaired cognitive-behavioral abilities in mice with knockout for Eif4h, a gene located in the mouse homolog of the Williams-Beuren syndrome critical region. Am J Pathol. 2012 Mar;180(3):1121-35
All references(45)
Disease annotation references (1)
Other
accession IDs
MGI:1196428, MGI:2141045, MGI:2444028

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory