About   Help   FAQ
Eif4h
Gene Detail
Symbol

Name
ID
Eif4h
eukaryotic translation initiation factor 4H
MGI:1341822
Synonyms
D5Ertd355e, E430026L18Rik, Eif4h, Wbscr1, Wscr1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
74.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:134619876-134639328 bp, - strand
From NCBI annotation of GRCm38

  19453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eif4h

Human
homologs
Human Homolog EIF4H, eukaryotic translation initiation factor 4H
NCBI Gene ID 7458
neXtProt AC  NX_Q15056
Human Synonyms  eIF-4H, WBSCR1, WSCR1
Human Chr (Location)  7q11.23; chr7:74174376-74197099 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(46) Targeted(3)
Genomic Mutations involving Eif4h (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit growth defects and impaired cognitive behaviors.
 
Human Diseases Modeled Using Mouse Eif4h (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Eif4h interacts with 209 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process developmental growth, sexual reproduction, ...
Component cytoplasm, membrane
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (59)    Tissues (51)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
Western blot 6
RT-PCR 12
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(20) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000040731 (Evidence)
Entrez Gene22384 (Evidence)
NIA Mouse Gene IndexU026803
PDB2DNG
Consensus CDS ProjectCCDS19723.1
International Mouse Knockout Project StatusEif4h
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22384 NCBI Gene Model | MGI Sequence Detail 19453 C57BL/6J ±  kb
transcript NM_033561 RefSeq | MGI Sequence Detail 2409 129/Sv 
polypeptide Q9WUK2 UniProt | EBI | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(4) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000007001 eukaryotic translation initiation factor 4H
Graphical View of Protein Domain Structure
References
(Earliest) J:55324 DeSilva U, et al., Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. Genome Res. 1999 May;9(5):428-36
(Latest) J:181945 Capossela S, et al., Growth defects and impaired cognitive-behavioral abilities in mice with knockout for Eif4h, a gene located in the mouse homolog of the Williams-Beuren syndrome critical region. Am J Pathol. 2012 Mar;180(3):1121-35
All references(45)
Disease annotation references (1)
Other
accession IDs
MGI:1196428, MGI:2141045, MGI:2444028

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory