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Lipg
Gene Detail
 Symbol
Name
ID
Lipg
lipase, endothelial
MGI:1341803
Synonyms 3110013K01Rik, EL, endothelial lipase, mEDL
Feature Type protein coding gene
Genetic Map
Chromosome 18
50.94 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr18:74939322-74961263 bp, - strand
From NCBI annotation of GRCm38

  21942 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21218  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Lipg

Human
homologs
Human Homolog LIPG, lipase, endothelial
NCBI Gene ID 9388
neXtProt AC  NX_Q9Y5X9
Human Synonyms  EDL, EL, PRO719
Human Chr (Location)  18q21.1; chr18:49560699-49592908 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased circulating total cholesterol and HDL as well as decreased monocyte binding to vascular endothelium.
 
Interactions
Lipg interacts with 263 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell proliferation, cholesterol homeostasis, ...
Component extracellular region, extracellular space
Function catalytic activity, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (354)    Tissues (133)    Images (55)
Theiler Stages: 10, 11, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 340
Northern blot 14
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000053846 (Evidence)
Entrez Gene16891 (Evidence)
UniGene299647
DFCITC1582337
DoTSDT.55275953, DT.99852447
NIA Mouse Gene IndexU038559
EC3.1.1.3
Consensus CDS ProjectCCDS29343.1
International Mouse Knockout Project StatusLipg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16891 NCBI Gene Model | MGI Sequence Detail 21942 C57BL/6J ±  kb
transcript NM_010720 RefSeq | MGI Sequence Detail 3787 C57BL/6 
polypeptide Q9WVG5 UniProt | EBI | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000734 Lipase
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR013818 Lipase, N-terminal
InterPro IPR002330 Lipoprotein lipase
InterPro IPR016272 Lipoprotein lipase, LIPH
InterPro IPR001024 Lipoxygenase, LH2
Protein Ontology PR:000009836 endothelial lipase
Graphical View of Protein Domain Structure
References (Earliest) J:54918 Hirata K, et al., Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem. 1999 May 14;274(20):14170-5
(Latest) J:199042 Escola-Gil JC, et al., Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. Biochim Biophys Acta. 2013 Apr;1831(4):691-7
All references(53)
Other
accession IDs
MGI:1920366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory