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Tlr6
Gene Detail
 Symbol
Name
ID
Tlr6
toll-like receptor 6
MGI:1341296
Feature Type protein coding gene
Genetic Map
Chromosome 5
33.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:64953095-64960034 bp, - strand
From NCBI annotation of GRCm38

  6940 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr6

Human
homologs
Human Homolog TLR6, toll-like receptor 6
NCBI Gene ID 10333
neXtProt AC  NX_Q9Y2C9
Human Synonyms  CD286
Human Chr (Location)  4p14; chr4:38823704-38856817 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene results in abnormal macrophage function.
 
Interactions
Tlr6 interacts with 26 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular response to diacyl bacterial lipopeptide, detection of diacyl bacterial lipopeptide, ...
Component cytoplasmic vesicle, integral component of membrane, ...
Function diacyl lipopeptide binding, lipopeptide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000051498 (Evidence)
Entrez Gene21899 (Evidence)
UniGene42146
DFCITC1586507
DoTSDT.101128556, DT.87028462
NIA Mouse Gene IndexU026239
PDB3A79
Consensus CDS ProjectCCDS19303.1
International Mouse Knockout Project StatusTlr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21899 NCBI Gene Model | MGI Sequence Detail 6940 C57BL/6J ±  kb
transcript NM_011604 RefSeq | MGI Sequence Detail 2600 C57BL/6 
polypeptide Q9EPW9 UniProt | EBI | MGI Sequence Detail 795 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(10) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(58 from dbSNP Build 137)    SNPs within 2kb including multiple locations(82)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027187 Toll-like receptor 6
Protein Ontology PR:000001157 Toll-like receptor 6
Graphical View of Protein Domain Structure
References (Earliest) J:179272 Deckwerth TL, et al., Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp Neurol. 1998 Jul;152(1):150-62
(Latest) J:209973 Shen KY, et al., Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells. J Immunol. 2014 May 1;192(9):4233-41
All references(93)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory