Tlr6
Gene Detail

Symbol Name ID

Tlr6 toll-like receptor 6 MGI:1341296

Feature Type

protein coding gene

Genetic Map

Chromosome 5

33.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:64953095-64960034 bp, - strand From NCBI annotation of GRCm38   6940 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr6

Human homologs

Human Homolog		TLR6, toll-like receptor 6
NCBI Gene ID		10333
neXtProt AC		NX_Q9Y2C9
Human Synonyms		CD286
Human Chr (Location)		4p14; chr4:38825325-38858438 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(4) Chemically induced(4)
 

Inactivation of this gene results in abnormal macrophage function.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	cellular response to diacyl bacterial lipopeptide, defense response to bacterium, ...
Component	cytoplasmic vesicle, integral to membrane, ...
Function	diacyl lipopeptide binding, lipopeptide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000051498 (Evidence)
Entrez Gene	21899 (Evidence)
UniGene	42146
DFCI	TC1586507
DoTS	DT.101128556, DT.87028462
NIA Mouse Gene Index	U026239
PDB	3A79
Consensus CDS Project	CCDS19303.1
International Mouse Knockout Project Status	Tlr6

Sequences

Length	Strain/Species
genomic	21899	NCBI Gene Model | MGI Sequence Detail	6940	C57BL/6J
transcript	NM_011604	RefSeq | MGI Sequence Detail	2600	C57BL/6
polypeptide	Q9EPW9	UniProt | EBI | MGI Sequence Detail	795	Not Applicable

All sequences(20) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR004075	Interleukin-1 receptor, type I/Toll precursor
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR003591	Leucine-rich repeat, typical subtype
InterPro	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
InterPro	IPR017241	Toll-like receptor
Protein Ontology	PR:000001157	toll-like receptor 6
Protein Ontology	PR:000027276	toll-like receptor 6 (mouse)

Graphical View of Protein Domain Structure

References

(Earliest) J:179272 Deckwerth TL, et al., Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp Neurol. 1998 Jul;152(1):150-62
(Latest) J:193776 Gaddis DE, et al., Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-gamma T cell response to Porphyromonas gingivalis. J Leukoc Biol. 2013 Jan;93(1):21-31
All references(87)