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Tlr6
Gene Detail
Symbol

Name
ID
Tlr6
toll-like receptor 6
MGI:1341296
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:64953106-64960048 bp, - strand
From Ensembl annotation of GRCm38

  6943 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog

HCOP human homology predictions: TLR6
Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr6

Human
homologs
TLR6, toll-like receptor 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10333
neXtProt AC: NX_Q9Y2C9

Human Synonyms: CD286

Human Chr (Location): 4p14; chr4:38823704-38857711 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(4) Radiation induced(1) Targeted(4)
Genomic Mutations involving Tlr6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene results in abnormal macrophage function.
 
Phenotype Images(4)
Interactions
Tlr6 interacts with 26 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100493946    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000051498 (Evidence)
Entrez Gene 21899 (Evidence)
UniGene 42146
DFCI TC1586507
DoTS DT.87028462, DT.101128556
NIA Mouse Gene Index U026239
PDB 3A79
Consensus CDS Project CCDS19303.1
International Mouse Phenotyping Consortium Status Tlr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051498 Ensembl Gene Model | MGI Sequence Detail 6943 C57BL/6J ±  kb
transcript ENSMUST00000062315 Ensembl | MGI Sequence Detail 2603 Not Applicable 
polypeptide ENSMUSP00000062096 Ensembl | MGI Sequence Detail 806 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(12) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(58 from dbSNP Build 137)    SNPs within 2kb including multiple locations(82)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027187 Toll-like receptor 6
Protein Ontology PR:000001157 Toll-like receptor 6
References
(Earliest) J:179272 Deckwerth TL, et al., Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp Neurol. 1998 Jul;152(1):150-62
(Latest) J:210328 Sanchez-Lopez JA, et al., Local activation of uterine Toll-like receptor 2 and 2/6 decreases embryo implantation and affects uterine receptivity in mice. Biol Reprod. 2014 Apr;90(4):87
All references(95)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory