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Parp2 Gene Detail
Summary
  • Symbol
    Parp2
  • Name
    poly (ADP-ribose) polymerase family, member 2
  • Synonyms
    Adprt2, Adprtl2, Aspartl2, C78626, PARP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341112
    NCBI Gene: 11546
  • Gene Overview
    MyGene.info: PARP2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:50807897-50821301 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 26.25 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341112
protein coding gene Chr14:50807841-50821301 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021258
protein coding gene Chr14:44758756-44771663 (+)
A/J MGP_AJ_G0021212
protein coding gene Chr14:43422267-43436514 (+)
AKR/J MGP_AKRJ_G0021188
protein coding gene Chr14:45051567-45065974 (+)
BALB/cJ MGP_BALBcJ_G0021215
protein coding gene Chr14:43536045-43549158 (+)
C3H/HeJ MGP_C3HHeJ_G0020997
protein coding gene Chr14:44876356-44893074 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021651
protein coding gene Chr14:46571547-46598568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019204
protein coding gene Chr14:42761892-42776614 (+)
CAST/EiJ MGP_CASTEiJ_G0020521
protein coding gene Chr14:41940193-41955365 (+)
CBA/J MGP_CBAJ_G0020964
protein coding gene Chr14:48067775-48083944 (+)
DBA/2J MGP_DBA2J_G0021088
protein coding gene Chr14:43318643-43332122 (+)
FVB/NJ MGP_FVBNJ_G0021069
protein coding gene Chr14:42945239-42959273 (+)
LP/J MGP_LPJ_G0021156
protein coding gene Chr14:45037421-45052032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021097
protein coding gene Chr14:47544128-47559383 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021681
protein coding gene Chr14:44546842-44563567 (+)
PWK/PhJ MGP_PWKPhJ_G0020271
protein coding gene Chr14:40217085-40230423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020096
protein coding gene Chr14:40706335-40719309 (+)
WSB/EiJ MGP_WSBEiJ_G0020574
protein coding gene Chr14:44739534-44752675 (+)



Homology
more
  • Human Ortholog
    PARP2, poly(ADP-ribose) polymerase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PARP2, poly(ADP-ribose) polymerase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADPRT2, ADPRTL2, ADPRTL3, ARTD2, pADPRT-2, PARP-2
  • Links
    NCBI Gene ID: 10038
    neXtProt AC: NX_Q9UGN5
    UniProt: Q9UGN5

  • Chr Location
    14q11.2; chr14:20343041-20357904 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant animals are sensitive to gamma radiation. Epithelial crypt degeneration and DNA repair deficiency is apparent following radiation-induced injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11546 NCBI Gene Model | MGI Sequence Detail 13405 C57BL/6J ±  kb
transcript NM_009632 RefSeq | MGI Sequence Detail 1819 C57BL/6  
polypeptide O88554 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 1
    cDNA 43
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1353643
References
more
  • Summaries
    All 65
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 25
  • Earliest
    J:54433 Berghammer H, et al., pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. FEBS Lett. 1999 Apr 23;449(2-3):259-63
  • Latest
    J:250977 Filliol A, et al., PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from concanavalin A-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G399-G409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory