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Parp2 Gene Detail
Summary
  • Symbol
    Parp2
  • Name
    poly (ADP-ribose) polymerase family, member 2
  • Synonyms
    Adprt2, Adprtl2, Aspartl2, C78626, PARP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341112
    NCBI Gene: 11546
  • Gene Overview
    MyGene.info: PARP2
Location & Maps
more
  • Sequence Map
    Chr14:50807946-50821300 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13355 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 26.25 cM, cytoband C1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PARP2, poly(ADP-ribose) polymerase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PARP2, poly(ADP-ribose) polymerase 2
    Orthology source: HomoloGene
  • Synonyms
    ADPRT2, ADPRTL2, ADPRTL3, ARTD2, pADPRT-2, PARP-2
  • Links
    NCBI Gene ID: 10038
    neXtProt AC: NX_Q9UGN5

  • Chr Location
    14q11.2; chr14:20343614-20357910 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Targeted
    2
  • Genomic Mutations
    1 involving Parp2
  • Incidental Mutations
Homozygous mutant animals are sensitive to gamma radiation. Epithelial crypt degeneration and DNA repair deficiency is apparent following radiation-induced injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036023 Ensembl Gene Model | MGI Sequence Detail 13355 C57BL/6J ±  kb
transcript ENSMUST00000036126 Ensembl | MGI Sequence Detail 1788 Not Applicable  
polypeptide ENSMUSP00000048877 Ensembl | MGI Sequence Detail 559 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    151 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 45
    Genomic 1
    cDNA 42
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1353643
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:54433 Berghammer H, et al., pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. FEBS Lett. 1999 Apr 23;449(2-3):259-63
  • Latest
    J:210861 Szanto M, et al., Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels. Biochim Biophys Acta. 2014 Apr;1842(4):594-602

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory