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Adcy8
Gene Detail
 Symbol
Name
ID
Adcy8
adenylate cyclase 8
MGI:1341110
Synonyms AC8
Feature Type protein coding gene
Genetic Map
Chromosome 15
29.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:64699042-64922296 bp, - strand
From Ensembl annotation of GRCm38

  223255 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy8

Human
homologs
Human Homolog ADCY8, adenylate cyclase 8 (brain)
NCBI Gene ID 114
neXtProt AC  NX_P40145
Human Synonyms  AC8, ADCY3, HBAC1
Human Chr (Location)  8q24; chr8:130780300-131040766 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Adcy8 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced body size (in female animals only), reduced anxiety, and impaired long term depression (LTD).
 
Interactions
Adcy8 interacts with 33 markers (Mir129-1, Mir129-2, Mir204, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, cAMP biosynthetic process, ...
Component integral component of membrane, intracellular, ...
Function adenylate cyclase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (441)    Tissues (204)    Images (51)
Theiler Stages: 12, 14, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 441
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(1) cDNA(33) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022376 (Evidence)
Entrez Gene11514 (Evidence)
UniGene1425
DFCITC1584033
DoTSDT.110817428, DT.110817432, DT.40171804, DT.91403168
NIA Mouse Gene IndexU036237
EC4.6.1.1
Consensus CDS ProjectCCDS27506.1
International Mouse Knockout Project StatusAdcy8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022376 Ensembl Gene Model | MGI Sequence Detail 223255 C57BL/6J ±  kb
transcript ENSMUST00000023007 Ensembl | MGI Sequence Detail 5032 Not Applicable 
polypeptide ENSMUSP00000023007 Ensembl | MGI Sequence Detail 1249 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(2010 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009398 Adenylate cyclase-like
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003759 adenylate cyclase type 8
References (Earliest) J:53342 Muglia LM, et al., The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice. J Neurosci. 1999 Mar 15;19(6):2051-8
(Latest) J:196671 Luo J, et al., Increases in cAMP, MAPK activity, and CREB phosphorylation during REM sleep: implications for REM sleep and memory consolidation. J Neurosci. 2013 Apr 10;33(15):6460-8
All references(69)
Other
accession IDs
MGI:2146186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory