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Adcy8 Gene Detail
Summary
  • Symbol
    Adcy8
  • Name
    adenylate cyclase 8
  • Synonyms
    AC8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341110
    NCBI Gene: 11514
  • Gene Overview
    MyGene.info: ADCY8
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:64699035-64922296 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.03 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1951 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341110
protein coding gene Chr15:64697084-64922296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021897
protein coding gene Chr15:64176517-64417723 (-)
A/J MGP_AJ_G0021856
protein coding gene Chr15:61713651-61950937 (-)
AKR/J MGP_AKRJ_G0021838
protein coding gene Chr15:63432682-63685050 (-)
BALB/cJ MGP_BALBcJ_G0021863
protein coding gene Chr15:61914370-62145331 (-)
C3H/HeJ MGP_C3HHeJ_G0021637
protein coding gene Chr15:63567965-63795107 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022302
protein coding gene Chr15:66666873-66902567 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019841
protein coding gene Chr15:58589806-58808950 (-)
CAST/EiJ MGP_CASTEiJ_G0021155
protein coding gene Chr15:64248304-64479502 (-)
CBA/J MGP_CBAJ_G0021603
protein coding gene Chr15:68922079-69177919 (-)
DBA/2J MGP_DBA2J_G0021727
protein coding gene Chr15:61542586-61764332 (-)
FVB/NJ MGP_FVBNJ_G0021709
protein coding gene Chr15:60577036-60791466 (-)
LP/J MGP_LPJ_G0021799
protein coding gene Chr15:64047130-64292050 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021732
protein coding gene Chr15:73920915-74178790 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022324
protein coding gene Chr15:63838565-64074929 (-)
PWK/PhJ MGP_PWKPhJ_G0020897
protein coding gene Chr15:61636278-61856700 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020738
protein coding gene Chr15:63653316-63915016 (-)
WSB/EiJ MGP_WSBEiJ_G0021207
protein coding gene Chr15:63805508-64037995 (-)



Homology
more
  • Human Ortholog
    ADCY8, adenylate cyclase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADCY8, adenylate cyclase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AC8, ADCY3, HBAC1
  • Links
    NCBI Gene ID: 114
    neXtProt AC: NX_P40145
    UniProt: P40145

  • Chr Location
    8q24.22; chr8:130780300-131041604 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced body size (in female animals only), reduced anxiety, and impaired long term depression (LTD).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11514 NCBI Gene Model | MGI Sequence Detail 223262 C57BL/6J ±  kb
    transcript NM_009623 RefSeq | MGI Sequence Detail 5064 C57BL/6  
    polypeptide P97490 UniProt | EBI | MGI Sequence Detail 1249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 34
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146186
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 16
      Phenotypes 64
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261627 Mori K, et al., Id2 determines intestinal identity through repression of the foregut transcription factor, Irx5. Mol Cell Biol. 2018 Feb 20;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory