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Adcy8
Gene Detail
Symbol

Name
ID
Adcy8
adenylate cyclase 8
MGI:1341110
Synonyms
AC8
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:64699042-64922296 bp, - strand
From Ensembl annotation of GRCm38

  223255 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADCY8
Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy8

Human
homologs
ADCY8, adenylate cyclase 8 (brain)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 114
neXtProt AC: NX_P40145

Human Synonyms: AC8, ADCY3, HBAC1

Human Chr (Location): 8q24; chr8:130780300-131041598 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Adcy8 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in reduced body size (in female animals only), reduced anxiety, and impaired long term depression (LTD).
 
Phenotype Images(2)
Interactions
Adcy8 interacts with 33 markers (Mir129-1, Mir129-2, Mir204, ...)
Expression
Literature Summary: (10 records)
Data Summary: Results (441)    Tissues (204)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 441
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adcy8    NEW 
Molecular
reagents
All nucleic(36) Genomic(1) cDNA(33) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022376 (Evidence)
Entrez Gene 11514 (Evidence)
UniGene 1425
DFCI TC1584033
DoTS DT.110817428, DT.110817432, DT.40171804, DT.91403168
NIA Mouse Gene Index U036237
EC 4.6.1.1
Consensus CDS Project CCDS27506.1
International Mouse Phenotyping Consortium Status Adcy8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022376 Ensembl Gene Model | MGI Sequence Detail 223255 C57BL/6J ±  kb
transcript ENSMUST00000023007 Ensembl | MGI Sequence Detail 5032 Not Applicable 
polypeptide ENSMUSP00000023007 Ensembl | MGI Sequence Detail 1249 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(2010 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR030672 Adenylate cyclase
InterPro IPR009398 Adenylate cyclase, conserved domain
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
InterPro IPR029787 Nucleotide cyclase
Protein Ontology PR:000003759 adenylate cyclase type 8
References
(Earliest) J:53342 Muglia LM, et al., The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice. J Neurosci. 1999 Mar 15;19(6):2051-8
(Latest) J:220774 Raoux M, et al., Multilevel control of glucose homeostasis by adenylyl cyclase 8. Diabetologia. 2015 Apr;58(4):749-57
All references(73)
Other
accession IDs
MGI:2146186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory