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Adcy8 Gene Detail
Summary
  • Symbol
    Adcy8
  • Name
    adenylate cyclase 8
  • Synonyms
    AC8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341110
    NCBI Gene: 11514
  • Gene Overview
    MyGene.info: ADCY8
Location & Maps
more
  • Sequence Map
    Chr15:64699042-64922296 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      223255 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADCY8, adenylate cyclase 8 (brain)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADCY8, adenylate cyclase 8 (brain)
    Orthology source: HomoloGene
  • Synonyms
    AC8, ADCY3, HBAC1
  • Links
    NCBI Gene ID: 114
    neXtProt AC: NX_P40145

  • Chr Location
    8q24; chr8:130780300-131041598 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    5 involving Adcy8
  • Incidental Mutations
Homozygous mutation of this gene results in reduced body size (in female animals only), reduced anxiety, and impaired long term depression (LTD).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022376 Ensembl Gene Model | MGI Sequence Detail 223255 C57BL/6J ±  kb
transcript ENSMUST00000023007 Ensembl | MGI Sequence Detail 5032 Not Applicable  
polypeptide ENSMUSP00000023007 Ensembl | MGI Sequence Detail 1249 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1951 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
less
  • All nucleic 36
    Genomic 1
    cDNA 33
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146186
References
more
  • Summaries
    All 70
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 5
    Phenotypes 59
  • Earliest
    J:53342 Muglia LM, et al., The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice. J Neurosci. 1999 Mar 15;19(6):2051-8
  • Latest
    J:220774 Raoux M, et al., Multilevel control of glucose homeostasis by adenylyl cyclase 8. Diabetologia. 2015 Apr;58(4):749-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory