Parp1
Gene Detail

Symbol Name ID

Parp1 poly (ADP-ribose) polymerase family, member 1 MGI:1340806

Synonyms

5830444G22Rik, Adprp, Adprt1, PARP, parp-1, sPARP-1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

84.44 cM, cytoband H5
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr1:180568975-180601254 bp, + strand From NCBI annotation of GRCm38   32280 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1222  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: poly(ADP-ribose) polymerase
Gene Tree: Parp1

Human homologs

Human Homolog		PARP1, poly (ADP-ribose) polymerase 1
NCBI Gene ID		142
neXtProt AC		NX_P09874
Human Synonyms		ADPRT, ADPRT1, ADPRT 1, ARTD1, pADPRT-1, PARP, PARP-1, PPOL
Human Chr (Location)		1q41-q42; chr1:226548392-226595801 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(27) : Targeted(9) Gene trapped(18)
 

Homozygous ablation of this gene may lead to skin hyperplasia, extreme sensitivity to radiation and alkylating agents, abnormal response to xenobiotics and endogenous compounds, reduced noise-induced hearing loss, altered susceptibility to neurotoxicity, or protection against renal ischemic injury.

 

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	base-excision repair, cellular response to insulin stimulus, ...
Component	cytoplasm, nuclear envelope, ...
Function	DNA binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (38)    Tissues (33)    Images (16)
Theiler Stages: 17, 20, 22, 25, 26, 28

Assay Type	Results
RNA in situ	32
Western blot	3
RT-PCR	3

cDNA source data(376)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(382) Genomic(4) cDNA(376) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000026496 (Evidence)
Entrez Gene	11545 (Evidence)
UniGene	277779
DFCI	TC1573830
DoTS	DT.101206137, DT.101409410, DT.494075
NIA Mouse Gene Index	U001190
EC	2.4.2.30
Consensus CDS Project	CCDS15569.1
International Mouse Knockout Project Status	Parp1

Sequences

Length	Strain/Species
genomic	11545	NCBI Gene Model | MGI Sequence Detail	32280	C57BL/6J
transcript	NM_007415	RefSeq | MGI Sequence Detail	3845	FVB/N
polypeptide	P11103	UniProt | EBI | MGI Sequence Detail	1013	Not Applicable

All sequences(41) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(5) : SNPs(172 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001357	BRCT domain
InterPro	IPR008288	NAD+ ADP-ribosyltransferase
InterPro	IPR012982	PADR1
InterPro	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain
InterPro	IPR004102	Poly(ADP-ribose) polymerase, regulatory domain
InterPro	IPR008893	WGR domain
InterPro	IPR001510	Zinc finger, PARP-type
Protein Ontology	PR:000012289	poly [ADP-ribose] polymerase 1

Graphical View of Protein Domain Structure

References

(Earliest) J:9813 Huppi K, et al., Sequence and organization of the mouse poly (ADP-ribose) polymerase gene. Nucleic Acids Res. 1989 May 11;17(9):3387-401
(Latest) J:195482 Calvo JA, et al., Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by parp1. PLoS Genet. 2013 Apr;9(4):e1003413
All references(279)

Other accession IDs

MGD-MRK-1132, MGI:2138374, MGI:2138692, MGI:87933