About   Help   FAQ
Parp1 Gene Detail
Summary
  • Symbol
    Parp1
  • Name
    poly (ADP-ribose) polymerase family, member 1
  • Synonyms
    5830444G22Rik, Adprp, Adprt1, PARP, parp-1, sPARP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340806
    NCBI Gene: 11545
  • Gene Overview
    MyGene.info: PARP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:180568924-180601254 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32331 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.44 cM, cytoband H5
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    PARP1, poly(ADP-ribose) polymerase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARP1, poly(ADP-ribose) polymerase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADPRT, ADPRT1, ADPRT 1, ARTD1, pADPRT-1, PARP, PARP-1, PPOL
  • Links
    NCBI Gene ID: 142
    neXtProt AC: NX_P09874
    UniProt: P09874

  • Chr Location
    1q42.12; chr1:226360691-226408100 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 5 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    169 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous ablation of this gene may lead to skin hyperplasia, extreme sensitivity to radiation and alkylating agents, abnormal response to xenobiotics and endogenous compounds, reduced noise-induced hearing loss, altered susceptibility to neurotoxicity,or protection against renal ischemic injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000050450 VEGA Gene Model | MGI Sequence Detail 32331 C57BL/6J ±  kb
    transcript OTTMUST00000128005 VEGA | MGI Sequence Detail 3873 Not Applicable  
    polypeptide OTTMUSP00000068942 VEGA | MGI Sequence Detail 1014 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      191 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 384
      Genomic 4
      cDNA 377
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1132, MGI:2138374, MGI:2138692, MGI:87933
    References
    more
    • Summaries
      All 362
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 28
      Phenotypes 169
    • Earliest
      J:9813 Huppi K, et al., Sequence and organization of the mouse poly (ADP-ribose) polymerase gene. Nucleic Acids Res. 1989 May 11;17(9):3387-401
    • Latest
      J:249307 Schuhwerk H, et al., Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo. Nucleic Acids Res. 2017 Nov 02;45(19):11174-11192

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory