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Parp1
Gene Detail
 Symbol
Name
ID
Parp1
poly (ADP-ribose) polymerase family, member 1
MGI:1340806
Synonyms 5830444G22Rik, Adprp, Adprt1, PARP, parp-1, sPARP-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
84.44 cM, cytoband H5
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr1:180568975-180601254 bp, + strand
From NCBI annotation of GRCm38

  32280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1222  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: poly(ADP-ribose) polymerase
Gene Tree: Parp1

Human
homologs
Human Homolog PARP1, poly (ADP-ribose) polymerase 1
NCBI Gene ID 142
neXtProt AC  NX_P09874
Human Synonyms  ADPRT, ADPRT1, ADPRT 1, ARTD1, pADPRT-1, PARP, PARP-1, PPOL
Human Chr (Location)  1q41-q42; chr1:226360691-226408100 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(18) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous ablation of this gene may lead to skin hyperplasia, extreme sensitivity to radiation and alkylating agents, abnormal response to xenobiotics and endogenous compounds, reduced noise-induced hearing loss, altered susceptibility to neurotoxicity, or protection against renal ischemic injury.
 
Interactions
Parp1 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process base-excision repair, cellular response to DNA damage stimulus, ...
Component cytoplasm, membrane, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (38)    Tissues (34)    Images (16)
Theiler Stages: 17, 20, 22, 25, 26, 27, 28
Assay TypeResults
RNA in situ 32
Western blot 3
RT-PCR 3
cDNA source data(377)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(383) Genomic(4) cDNA(377) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000026496 (Evidence)
Entrez Gene11545 (Evidence)
UniGene277779
DFCITC1573830
DoTSDT.101206137, DT.101409410, DT.494075
NIA Mouse Gene IndexU001190
EC2.4.2.30
Consensus CDS ProjectCCDS15569.1
International Mouse Knockout Project StatusParp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11545 NCBI Gene Model | MGI Sequence Detail 32280 C57BL/6J ±  kb
transcript NM_007415 RefSeq | MGI Sequence Detail 3845 FVB/N 
polypeptide P11103 UniProt | EBI | MGI Sequence Detail 1013 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(9)
Polymorphisms RFLP(5) : SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR008288 NAD+ ADP-ribosyltransferase
InterPro IPR012982 PADR1
InterPro IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
InterPro IPR004102 Poly(ADP-ribose) polymerase, regulatory domain
InterPro IPR008893 WGR domain
InterPro IPR001510 Zinc finger, PARP-type
Protein Ontology PR:000012289 poly [ADP-ribose] polymerase 1
Graphical View of Protein Domain Structure
References (Earliest) J:9813 Huppi K, et al., Sequence and organization of the mouse poly (ADP-ribose) polymerase gene. Nucleic Acids Res. 1989 May 11;17(9):3387-401
(Latest) J:208566 Kassan M, et al., Enhanced NF-kappaB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Diabetes. 2013 Jun;62(6):2078-87
All references(300)
Other
accession IDs
MGD-MRK-1132, MGI:2138374, MGI:2138692, MGI:87933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory