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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Parp1
poly (ADP-ribose) polymerase family, member 1
MGI:1340806
15 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Parp1tm1Zqw/Parp1tm1Zqw
involves: 129S2/SvPas * 129S6/SvEvTac 		abnormal centrosome morphology J:139260
abnormal chromosome morphology J:139260
aneuploidy J:139260
decreased cell proliferation J:139260
decreased embryo size J:139260
decreased telomere length J:139260
exencephaly J:139260
lethality throughout fetal growth and development, complete penetrance J:139260
Parp1tm1Jmdm/Parp1+
Parp2tm1Jmdm/Parp2tm1Jmdm
involves: 129S2/SvPas * C57BL/6 		aneuploidy J:83371
chromosomal instability J:83371
decreased litter size J:83371
embryonic growth arrest J:83371
embryonic lethality during organogenesis, incomplete penetrance J:83371
reduced female fertility J:83371
Parp1tm1Jmdm/Parp1tm1Jmdm
Parp2tm1Jmdm/Parp2tm1Jmdm
involves: 129S2/SvPas * C57BL/6 		embryonic growth arrest J:83371
embryonic lethality, complete penetrance J:83371
Parp1tm1Jmdm/Parp1tm1Jmdm
Parp3tm1.2Ics/Parp3tm1.2Ics
involves: 129S2/SvPas * C57BL/6 * SJL 		increased mortality induced by ionizing radiation J:170941
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory