Gpr56
Gene Detail

Symbol Name ID

Gpr56 G protein-coupled receptor 56 MGI:1340051

Synonyms

Cyt28

Feature Type

protein coding gene

Genetic Map

Chromosome 8

47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:94977109-95014208 bp, + strand From NCBI annotation of GRCm38   37100 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: G protein-coupled receptor 56
Gene Tree: Gpr56

Human homologs

Human Homolog		GPR56, G protein-coupled receptor 56
NCBI Gene ID		9289
neXtProt AC		NX_Q9Y653
Human Synonyms		BFPP, TM7LN4, TM7XN1
Human Chr (Location)		16q13; chr16:57653910-57698944 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GPR56

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice homozygous for a null allele exhibit neuronal ectopias in the frontoparietal cortex due to disruptions in the pial basement membrane.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	brain development, cell adhesion, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (482)    Tissues (61)    Images (67)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	482

cDNA source data(133)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(137) Genomic(1) cDNA(135) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000031785 (Evidence)
Entrez Gene	14766 (Evidence)
UniGene	290834
DFCI	TC1572574, TC1587656, TC1730408
DoTS	DT.101323809, DT.534001
NIA Mouse Gene Index	U009679
Consensus CDS Project	CCDS22553.1
International Mouse Knockout Project Status	Gpr56

Sequences

Length	Strain/Species
genomic	14766	NCBI Gene Model | MGI Sequence Detail	37100	C57BL/6J
transcript	NM_001198894	RefSeq | MGI Sequence Detail	3605	C57BL/6
polypeptide	Q8K209	UniProt | EBI | MGI Sequence Detail	687	Not Applicable

All sequences(38) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR003910	GPCR, family 2, orphan receptor, GPR56
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR000203	GPS domain
Protein Ontology	PR:000008189	G-protein coupled receptor 56

Graphical View of Protein Domain Structure

References

(Earliest) J:53199 Liu M, et al., GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics. 1999 Feb 1;55(3):296-305
(Latest) J:187339 Jeong SJ, et al., Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012 Sep 1;520(13):2930-40
All references(42)