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Adgrg1 Gene Detail
Summary
  • Symbol
    Adgrg1
  • Name
    adhesion G protein-coupled receptor G1
  • Synonyms
    Cyt28, Gpr56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340051
    NCBI Gene: 14766
  • Gene Overview
    MyGene.info: ADGRG1
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94974756-95014208 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    561 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340051
protein coding gene Chr8:94974751-95014217 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033976
protein coding gene Chr8:96428448-96467037 (+)
A/J MGP_AJ_G0033959
protein coding gene Chr8:92666390-92704193 (+)
AKR/J MGP_AKRJ_G0033885
protein coding gene Chr8:95191859-95230680 (+)
BALB/cJ MGP_BALBcJ_G0033951
protein coding gene Chr8:92749697-92787742 (+)
C3H/HeJ MGP_C3HHeJ_G0033661
protein coding gene Chr8:95909482-95947904 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034472
protein coding gene Chr8:99942472-99980171 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031413
protein coding gene Chr8:86467998-86506003 (+)
CAST/EiJ MGP_CASTEiJ_G0032993
protein coding gene Chr8:95513299-95551659 (+)
CBA/J MGP_CBAJ_G0033637
protein coding gene Chr8:103245324-103288305 (+)
DBA/2J MGP_DBA2J_G0033791
protein coding gene Chr8:92154527-92192042 (+)
FVB/NJ MGP_FVBNJ_G0033738
protein coding gene Chr8:91097747-91135819 (+)
LP/J MGP_LPJ_G0033883
protein coding gene Chr8:96570252-96608819 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033780
protein coding gene Chr8:105519857-105559198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034490
protein coding gene Chr8:95358894-95395882 (+)
PWK/PhJ MGP_PWKPhJ_G0032695
protein coding gene Chr8:91513740-91553145 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032532
protein coding gene Chr8:94210425-94247563 (+)
WSB/EiJ MGP_WSBEiJ_G0033105
protein coding gene Chr8:95894558-95933520 (+)



Homology
more
  • Human Ortholog
    ADGRG1, adhesion G protein-coupled receptor G1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADGRG1, adhesion G protein-coupled receptor G1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BFPP, BPPR, GPR56, TM7LN4, TM7XN1
  • Links
    NCBI Gene ID: 9289
    neXtProt AC: NX_Q9Y653
    UniProt: Q9Y653

  • Chr Location
    16q21; chr16:57619535-57665039 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neuronal ectopias in the frontoparietal cortex due to disruptions in the pial basement membrane.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14766 NCBI Gene Model | MGI Sequence Detail 39453 C57BL/6J ±  kb
    transcript NM_001198894 RefSeq | MGI Sequence Detail 3605 C57BL/6  
    polypeptide Q8K209 UniProt | EBI | MGI Sequence Detail 687 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      Genomic 1
      cDNA 137
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 18
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:53199 Liu M, et al., GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics. 1999 Feb 1;55(3):296-305
    • Latest
      J:264148 Giera S, et al., Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018 May 29;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory