Adam22 MGI Mouse Gene Detail - MGI:1340046 - a disintegrin and metallopeptidase domain 22

Adam22 Gene Detail

Symbol

Adam22
Name

a disintegrin and metallopeptidase domain 22
Synonyms

2900022I03Rik, MDC2

Feature Type

protein coding gene
IDs

MGI:1340046
NCBI Gene: 11496
Gene Overview

MyGene.info: ADAM22
Alliance

gene page

Sequence Map

Chr5:8072352-8368160 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

295809 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 3.39 cM
Mapping Data

3 experiments

Human Ortholog

ADAM22, ADAM metallopeptidase domain 22

Vertebrate Orthologs

9

Human Ortholog

ADAM22, ADAM metallopeptidase domain 22
Orthology source: HomoloGene, HGNC
Synonyms

ADAM 22, EIEE61, MDC2
Links

HGNC:201

NCBI Gene ID: 53616

neXtProt AC: NX_Q9P0K1

UniProt: Q9P0K1
Chr Location

7q21.12; chr7:87934143-88202889 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 37898
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ADAM22
Gene Tree

Adam22

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Phenotype Summary

12 phenotypes from 2 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
3 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves.

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All GO Annotations

22
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

8
Tissues

7
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADAM22

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Adam22 interacts with 476 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

175
RefSeq

36
UniProt

19
CCDS

CCDS19080.1, CCDS51411.1, CCDS80205.1, CCDS80207.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016341	VEGA Gene Model \| MGI Sequence Detail	295809	C57BL/6J	± kb
transcript	OTTMUST00000039269	VEGA \| MGI Sequence Detail	9077	Not Applicable
polypeptide	OTTMUSP00000017551	VEGA \| MGI Sequence Detail	904	Not Applicable

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SNPs within 2kb

2791 from dbSNP Build 142

PCR

1

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UniProt

19 Sequences
Protein Ontology

PR:000003718 disintegrin and metalloproteinase domain-containing protein 22

(term hierarchy)
InterPro Domains

IPR006586 ADAM, cysteine-rich

IPR018358 Disintegrin, conserved site

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type

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All nucleic 10

cDNA 7

Primer pair 2

Other 1

Microarray probesets 5

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MGI:1920099, MGI:2141002

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 10
Earliest

J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
Latest

J:230557 Chen N, et al., Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. Biochim Biophys Acta. 2015 Jul;1854(7):827-33

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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