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Adam22 Gene Detail
Summary
  • Symbol
    Adam22
  • Name
    a disintegrin and metallopeptidase domain 22
  • Synonyms
    2900022I03Rik, MDC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340046
    NCBI Gene: 11496
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:8122352-8418160 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15579 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340046
 protein coding gene Chr5:8122352-8418312 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029281
 protein coding gene Chr5:5034444-5331006 (-)
A/J MGP_AJ_G0029245
 protein coding gene Chr5:4874879-5179338 (-)
AKR/J MGP_AKRJ_G0029194
 protein coding gene Chr5:4997514-5313159 (-)
BALB/cJ MGP_BALBcJ_G0029262
 protein coding gene Chr5:5093744-5380591 (-)
C3H/HeJ MGP_C3HHeJ_G0028982
 protein coding gene Chr5:5198907-5497529 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029712
 protein coding gene Chr5:5522738-5846897 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026955
 protein coding gene Chr5:4704336-4796655 (-)
CAST/EiJ MGP_CASTEiJ_G0028395
 protein coding gene Chr5:5068501-5361122 (-)
CBA/J MGP_CBAJ_G0028943
 protein coding gene Chr5:5648793-5957123 (-)
DBA/2J MGP_DBA2J_G0029097
 protein coding gene Chr5:5006149-5299356 (-)
FVB/NJ MGP_FVBNJ_G0029057
 protein coding gene Chr5:4800034-5098063 (-)
LP/J MGP_LPJ_G0029186
 protein coding gene Chr5:5160711-5464068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029084
 protein coding gene Chr5:5636796-5980104 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029743
 protein coding gene Chr5:5016207-5297054 (-)
PWK/PhJ MGP_PWKPhJ_G0028117
 protein coding gene Chr5:4807840-5094190 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027950
 protein coding gene Chr5:5204253-5488158 (-)
WSB/EiJ MGP_WSBEiJ_G0028475
 protein coding gene Chr5:5006412-5299360 (-)



Homology
more
  • Human Ortholog
    ADAM22, ADAM metallopeptidase domain 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM22, ADAM metallopeptidase domain 22
  • Synonyms
    ADAM 22, DEE61, EIEE61, MDC2
  • Links
    NCBI Gene ID: 53616
    UniProt: Q9P0K1

  • Chr Location
    7q21.12; chr7:87934143-88202889 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADAM22 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    8
  • cDNA Data
    5
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040537 Ensembl Gene Model | MGI Sequence Detail 295809 C57BL/6J ±  kb
    transcript ENSMUST00000088744 Ensembl | MGI Sequence Detail 9245 Not Applicable  
    polypeptide ENSMUSP00000086122 Ensembl | MGI Sequence Detail 927 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 7
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920099, MGI:2141002
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 17
      Phenotypes 15
    • Earliest
      J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
    • Latest
      J:328338 Yokoi N, et al., 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice. Cell Rep. 2021 Dec 14;37(11):110107
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory