Adam22
Gene Detail

Symbol

Name
ID

Adam22
a disintegrin and metallopeptidase domain 22
MGI:1340046

Synonyms

2900022I03Rik, MDC2

Feature Type

protein coding gene

Genetic Map

Chromosome 5
3.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:8072352-8368160 bp, - strand From VEGA annotation of GRCm38   295809 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:37898  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Adam22

Human
homologs

Human Homolog		ADAM22, ADAM metallopeptidase domain 22
NCBI Gene ID		53616
neXtProt AC		NX_Q9P0K1
Human Synonyms		ADAM 22, MDC2
Human Chr (Location)		7q21; chr7:87934251-88202889 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves.

 
Phenotype Images(3)

Interactions

Adam22 interacts with 477 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (15 annotations)

Process	adult locomotory behavior, gliogenesis, ...
Component	axon, cell projection, ...
Function	metalloendopeptidase activity, metallopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (8)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	6
RT-PCR	2

cDNA source data(5)
External Resources: GEO   Expression Atlas

Molecular
reagents

All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000016341 (Evidence)
Ensembl Gene Model	ENSMUSG00000040537 (Evidence)
Entrez Gene	11496 (Evidence)
DFCI	TC1699670, TC1607919, TC1604196, TC1602858
DoTS	DT.110674513, DT.110674512, DT.110674469, DT.110674500, DT.94172413, DT.110674497, DT.110674477, DT.110674474, DT.110674472, DT.110674478, DT.110674493, DT.110674485, DT.110674481, DT.486084, DT.110674507, DT.110674510, DT.110674503, DT.110674504, DT.40144499, DT.40143548, DT.110674517, DT.110674514
NIA Mouse Gene Index	U005254
Consensus CDS Project	CCDS19080.1, CCDS51411.1
International Mouse Knockout Project Status	Adam22

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016341	VEGA Gene Model | MGI Sequence Detail	295809	C57BL/6J
transcript	OTTMUST00000039269	VEGA | MGI Sequence Detail	9077	Not Applicable
polypeptide	OTTMUSP00000017551	VEGA | MGI Sequence Detail	904	Not Applicable

All sequences(191) RefSeq(37) UniProt(17)

Polymorphisms

PCR(1) : SNPs within 2kb(2829 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2881)

Protein-related
information

Resource	ID	Description
InterPro	IPR006586	ADAM, cysteine-rich
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR018358	Disintegrin, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide
Protein Ontology	PR:000003718	disintegrin and metalloproteinase domain-containing protein 22

References

(Earliest) J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
(Latest) J:208847 Kegel L, et al., Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Development. 2014 Apr;141(8):1749-56
All references(37)

Other
accession IDs

MGI:1920099, MGI:2141002