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Adam22
Gene Detail
Symbol

Name
ID
Adam22
a disintegrin and metallopeptidase domain 22
MGI:1340046
Synonyms
2900022I03Rik, MDC2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
3.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:8072352-8368160 bp, - strand
From VEGA annotation of GRCm38

  295809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37898  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Adam22

Human
homologs
Human Homolog ADAM22, ADAM metallopeptidase domain 22
NCBI Gene ID 53616
neXtProt AC  NX_Q9P0K1
Human Synonyms  ADAM 22, MDC2
Human Chr (Location)  7q21; chr7:87934251-88202889 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves.
 
Phenotype Images(3)
Interactions
Adam22 interacts with 477 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process adult locomotory behavior, gliogenesis, ...
Component axon, integral component of membrane, ...
Function metalloendopeptidase activity, metallopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
RT-PCR 2
cDNA source data(5)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(5)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016341 VEGA Gene Model | MGI Sequence Detail 295809 C57BL/6J ±  kb
transcript OTTMUST00000039269 VEGA | MGI Sequence Detail 9077 Not Applicable 
polypeptide OTTMUSP00000017551 VEGA | MGI Sequence Detail 904 Not Applicable 

For the selected sequences
All sequences(207) RefSeq(37) UniProt(33)
Polymorphisms
PCR(1) : SNPs within 2kb(2829 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2881)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003718 disintegrin and metalloproteinase domain-containing protein 22
References
(Earliest) J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
(Latest) J:208847 Kegel L, et al., Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Development. 2014 Apr;141(8):1749-56
All references(37)
Other
accession IDs
MGI:1920099, MGI:2141002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory