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Adam22 Gene Detail
Summary
  • Symbol
    Adam22
  • Name
    a disintegrin and metallopeptidase domain 22
  • Synonyms
    2900022I03Rik, MDC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340046
    NCBI Gene: 11496
  • Gene Overview
    MyGene.info: ADAM22
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:8072352-8368160 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      295809 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.39 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAM22, ADAM metallopeptidase domain 22
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADAM22, ADAM metallopeptidase domain 22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM 22, EIEE61, MDC2
  • Links
    NCBI Gene ID: 53616
    neXtProt AC: NX_Q9P0K1
    UniProt: Q9P0K1

  • Chr Location
    7q21.12; chr7:87934143-88202889 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    8
  • Tissues
    7
  • cDNA Data
    5
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016341 VEGA Gene Model | MGI Sequence Detail 295809 C57BL/6J ±  kb
    transcript OTTMUST00000039269 VEGA | MGI Sequence Detail 9077 Not Applicable  
    polypeptide OTTMUSP00000017551 VEGA | MGI Sequence Detail 904 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2791 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920099, MGI:2141002
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
    • Latest
      J:230557 Chen N, et al., Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. Biochim Biophys Acta. 2015 Jul;1854(7):827-33
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory