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Adam22
Gene Detail
 Symbol
Name
ID
Adam22
a disintegrin and metallopeptidase domain 22
MGI:1340046
Synonyms 2900022I03Rik, MDC2
Feature Type protein coding gene
Genetic Map
Chromosome 5
3.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:8072352-8368160 bp, - strand
From VEGA annotation of GRCm38

  295809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37898  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adam22

Human
homologs
Human Homolog ADAM22, ADAM metallopeptidase domain 22
NCBI Gene ID 53616
neXtProt AC  NX_Q9P0K1
Human Synonyms  ADAM 22, MDC2
Human Chr (Location)  7q21; chr7:87934251-88202889 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves.
 
Phenotype Images(3)
Interactions
Adam22 interacts with 477 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process adult locomotory behavior, gliogenesis, ...
Component extracellular region, integral component of membrane, ...
Function metalloendopeptidase activity, metallopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (7)    Images (1)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 6
RT-PCR 2
cDNA source data(5)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016341 (Evidence)
Ensembl Gene ModelENSMUSG00000040537 (Evidence)
Entrez Gene11496 (Evidence)
DFCITC1602858, TC1604196, TC1607919, TC1699670
DoTSDT.110674469, DT.110674472, DT.110674474, DT.110674477, DT.110674478, DT.110674481, DT.110674485, DT.110674493, DT.110674497, DT.110674500, DT.110674503, DT.110674504, DT.110674507, DT.110674510, DT.110674512, DT.110674513, DT.110674514, DT.110674517, DT.40143548, DT.40144499, DT.486084, DT.94172413
NIA Mouse Gene IndexU005254
Consensus CDS ProjectCCDS19080.1, CCDS51411.1
International Mouse Knockout Project StatusAdam22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016341 VEGA Gene Model | MGI Sequence Detail 295809 C57BL/6J ±  kb
transcript OTTMUST00000039269 VEGA | MGI Sequence Detail 9077 Not Applicable 
polypeptide OTTMUSP00000017551 VEGA | MGI Sequence Detail 904 Not Applicable 

For the selected sequences
All sequences(191) RefSeq(37) UniProt(17)
Polymorphisms PCR(1) : SNPs within 2kb(2829 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2881)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003718 disintegrin and metalloproteinase domain-containing protein 22
References (Earliest) J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
(Latest) J:173488 Pandey P, et al., Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol. 2011;5:56
All references(36)
Other
accession IDs
MGI:1920099, MGI:2141002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory