Smc3
Gene Detail

Symbol Name ID

Smc3 structural maintenance of chromosomes 3 MGI:1339795

Synonyms

Bamacan, Cspg6, Mmip1, SmcD

Feature Type

protein coding gene

Genetic Map

Chromosome 19

48.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:53600398-53645833 bp, + strand From VEGA annotation of GRCm38   45436 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Smc3

Human homologs

Human Homolog		SMC3, structural maintenance of chromosomes 3
NCBI Gene ID		9126
neXtProt AC		NX_Q9UQE7
Human Synonyms		BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1
Human Chr (Location)		10q25; chr10:112327449-112364392 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SMC3

Alleles and phenotypes

All alleles(20) : Targeted(2) Gene trapped(18)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	cell cycle, cell division, ...
Component	basement membrane, chromatin, ...
Function	ATP binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (188)    Tissues (104)    Images (32)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	188

cDNA source data(323)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(325) Genomic(2) cDNA(323)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024643 (Evidence)
Ensembl Gene Model	ENSMUSG00000024974 (Evidence)
Entrez Gene	13006 (Evidence)
UniGene	14910
DFCI	TC1571968, TC1606188
DoTS	DT.536622
NIA Mouse Gene Index	U019573
PDB	2WD5
Consensus CDS Project	CCDS38025.1
International Mouse Knockout Project Status	Smc3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024643	VEGA Gene Model | MGI Sequence Detail	45436	C57BL/6J
transcript	OTTMUST00000060579	VEGA | MGI Sequence Detail	4851	Not Applicable
polypeptide	OTTMUSP00000029555	VEGA | MGI Sequence Detail	1217	Not Applicable

All sequences(45) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(2) : SNPs(138 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003395	RecF/RecN/SMC
InterPro	IPR010935	SMCs flexible hinge
Protein Ontology	PR:000015272	structural maintenance of chromosomes protein 3

References

(Earliest) J:46395 Gupta K, et al., Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Oncogene. 1998 Mar 5;16(9):1149-59
(Latest) J:185743 Cotney J, et al., Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
All references(59)

Other accession IDs

MGI:1261435