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Smc3
Gene Detail
 Symbol
Name
ID
Smc3
structural maintenance of chromosomes 3
MGI:1339795
Synonyms Bamacan, Cspg6, Mmip1, SmcD
Feature Type protein coding gene
Genetic Map
Chromosome 19
48.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:53600398-53645833 bp, + strand
From VEGA annotation of GRCm38

  45436 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Smc3

Human
homologs
Human Homolog SMC3, structural maintenance of chromosomes 3
NCBI Gene ID 9126
neXtProt AC  NX_Q9UQE7
Human Synonyms  BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1
Human Chr (Location)  10q25; chr10:110567691-110604634 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SMC3
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality. Mice heterozygous for this allele exhibit partial postnatal lethality, decreased body weight, abnormal craniofacial morphology, and increased T cell number.
 
Interactions
Smc3 interacts with 218 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell cycle, cell division, ...
Component basement membrane, chromatin, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (188)    Tissues (104)    Images (32)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 188
cDNA source data(323)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(325) Genomic(2) cDNA(323)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024643 (Evidence)
Ensembl Gene ModelENSMUSG00000024974 (Evidence)
Entrez Gene13006 (Evidence)
UniGene14910
DFCITC1571968, TC1606188
DoTSDT.536622
NIA Mouse Gene IndexU019573
PDB2WD5
Consensus CDS ProjectCCDS38025.1
International Mouse Knockout Project StatusSmc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024643 VEGA Gene Model | MGI Sequence Detail 45436 C57BL/6J ±  kb
transcript OTTMUST00000060579 VEGA | MGI Sequence Detail 4851 Not Applicable 
polypeptide OTTMUSP00000029555 VEGA | MGI Sequence Detail 1217 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(9)
Polymorphisms RFLP(2) : SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR003395 RecF/RecN/SMC
InterPro IPR010935 SMCs flexible hinge
Protein Ontology PR:000015272 structural maintenance of chromosomes protein 3
References (Earliest) J:46395 Gupta K, et al., Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Oncogene. 1998 Mar 5;16(9):1149-59
(Latest) J:200082 White JK, et al., Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell. 2013 Jul 18;154(2):452-64
All references(61)
Other
accession IDs
MGI:1261435

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory