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Csf3r
Gene Detail
Symbol

Name
ID
Csf3r
colony stimulating factor 3 receptor (granulocyte)
MGI:1339755
Synonyms
Cd114, Csfgr, G-CSFR
Feature Type
protein coding gene
Genetic Map
Chromosome 4
59.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr4:126024550-126044440 bp, + strand
From VEGA annotation of GRCm38

  19891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:601  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Csf3r

Human
homologs
Human Homolog CSF3R, colony stimulating factor 3 receptor (granulocyte)
NCBI Gene ID 1441
neXtProt AC  NX_Q99062
Human Synonyms  CD114, GCSFR
Human Chr (Location)  1p35-p34.3; chr1:36466043-36483314 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CSF3R
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced numbers of peripheral neutrophils, with fewer hematopoietic progenitors in bone marrow and impaired expansion and terminal differentiation of progenitors into granulocytes.
 
Human Diseases Modeled Using Mouse Csf3r (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Csf3r interacts with 77 markers (Mir20a, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell adhesion, neutrophil chemotaxis
Component integral component of membrane, membrane
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (40)    Tissues (18)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 3
RT-PCR 37
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(3) cDNA(41) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009297 (Evidence)
Ensembl Gene ModelENSMUSG00000028859 (Evidence)
Entrez Gene12986 (Evidence)
UniGene271701
DFCITC1579871
DoTSDT.101387189, DT.60104787
NIA Mouse Gene IndexU004807
PDB1GCF, 1CTO, 1PGR, 1CD9
Consensus CDS ProjectCCDS18640.1
International Mouse Knockout Project StatusCsf3r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009297 VEGA Gene Model | MGI Sequence Detail 19891 C57BL/6J ±  kb
transcript OTTMUST00000021097 VEGA | MGI Sequence Detail 3481 Not Applicable 
polypeptide OTTMUSP00000009665 VEGA | MGI Sequence Detail 837 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(29) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR010457 Immunoglobulin C2-set-like, ligand-binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000001353 granulocyte colony-stimulating factor receptor
References
(Earliest) J:10454 Fukunaga R, et al., Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell. 1990 Apr 20;61(2):341-50
(Latest) J:201408 Kook S, et al., The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells. J Clin Invest. 2013 Aug 1;123(8):3420-35
All references(94)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-2190, MGI:88533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory