About   Help   FAQ
Csf3r
Gene Detail
Symbol

Name
ID
Csf3r
colony stimulating factor 3 receptor (granulocyte)
MGI:1339755
Synonyms
Cd114, Csfgr, G-CSFR
Feature Type
protein coding gene
Genetic Map
Chromosome 4
59.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr4:126024550-126044440 bp, + strand
From VEGA annotation of GRCm38

  19891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:601  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSF3R
Gene Tree: Csf3r

Human
homologs
CSF3R, colony stimulating factor 3 receptor (granulocyte)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1441
neXtProt AC: NX_Q99062

Human Synonyms: CD114, GCSFR

Human Chr (Location): 1p35-p34.3; chr1:36466043-36483314 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CSF3R

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Targeted(9)
Genomic Mutations involving Csf3r (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced numbers of peripheral neutrophils, with fewer hematopoietic progenitors in bone marrow and impaired expansion and terminal differentiation of progenitors into granulocytes.
 
Human Diseases Modeled in Mice Using Csf3r (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Csf3r interacts with 77 markers (Mir20a, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell adhesion, neutrophil chemotaxis, ...
Component integral component of membrane, membrane
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (40)    Tissues (18)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 3
RT-PCR 37
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase csf3r ; ZFIN csf3r    NEW 
Molecular
reagents
All nucleic(50) Genomic(3) cDNA(41) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009297 (Evidence)
Ensembl Gene Model ENSMUSG00000028859 (Evidence)
Entrez Gene 12986 (Evidence)
UniGene 271701
DFCI TC1579871
DoTS DT.101387189, DT.60104787
NIA Mouse Gene Index U004807
PDB 1CD9, 1CTO, 1GCF, 1PGR
Consensus CDS Project CCDS18640.1
International Mouse Phenotyping Consortium Status Csf3r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009297 VEGA Gene Model | MGI Sequence Detail 19891 C57BL/6J ±  kb
transcript OTTMUST00000021097 VEGA | MGI Sequence Detail 3481 Not Applicable 
polypeptide OTTMUSP00000009665 VEGA | MGI Sequence Detail 837 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(33) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR010457 Immunoglobulin C2-set-like, ligand-binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000001353 granulocyte colony-stimulating factor receptor
References
(Earliest) J:10454 Fukunaga R, et al., Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell. 1990 Apr 20;61(2):341-50
(Latest) J:220022 Casbon AJ, et al., Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75
All references(97)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-2190, MGI:88533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory