Csf3r
Gene Detail

Symbol Name ID

Csf3r colony stimulating factor 3 receptor (granulocyte) MGI:1339755

Synonyms

Cd114, Csfgr, G-CSFR

Feature Type

protein coding gene

Genetic Map

Chromosome 4

59.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr4:126024550-126044440 bp, + strand From VEGA annotation of GRCm38   19891 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:601  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Csf3r

Human homologs

Human Homolog		CSF3R, colony stimulating factor 3 receptor (granulocyte)
NCBI Gene ID		1441
neXtProt AC		NX_Q99062
Human Synonyms		CD114, GCSFR
Human Chr (Location)		1p35-p34.3; chr1:36931644-36948915 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CSF3R

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Homozygotes for targeted null mutations exhibit reduced numbers of peripheral neutrophils, with fewer hematopoietic progenitors in bone marrow and impaired expansion and terminal differentiation of progenitors into granulocytes.

 
Human Diseases Modeled Using Mouse Csf3r (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	cell adhesion, neutrophil chemotaxis
Component	integral to membrane, membrane
Function	cytokine receptor activity

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (41)    Tissues (19)    Images (1)
Theiler Stages: 4, 14, 15, 17, 18, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Northern blot	3
RT-PCR	38

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(3) cDNA(41) Primer pair(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009297 (Evidence)
Ensembl Gene Model	ENSMUSG00000028859 (Evidence)
Entrez Gene	12986 (Evidence)
UniGene	271701
DFCI	TC1579871
DoTS	DT.101387189, DT.60104787
NIA Mouse Gene Index	U004807
PDB	1CTO, 1GCF, 1PGR, 1CD9
Consensus CDS Project	CCDS18640.1
International Mouse Knockout Project Status	Csf3r

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009297	VEGA Gene Model | MGI Sequence Detail	19891	C57BL/6J
transcript	OTTMUST00000021097	VEGA | MGI Sequence Detail	3481	Not Applicable
polypeptide	OTTMUSP00000009665	VEGA | MGI Sequence Detail	837	Not Applicable

All sequences(30) RefSeq(5) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR010457	Immunoglobulin C2-set-like, ligand-binding
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology	PR:000001353	granulocyte colony-stimulating factor receptor

References

(Earliest) J:10454 Fukunaga R, et al., Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell. 1990 Apr 20;61(2):341-50
(Latest) J:193750 Chee LC, et al., The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation. J Leukoc Biol. 2013 Feb;93(2):235-43
All references(89)

Other accession IDs

MGD-MRK-2190, MGI:88533