Csf2ra
Gene Detail

Symbol Name ID

Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) MGI:1339754

Synonyms

CD116, Csfgmra, GM-CSF-Ra, GM-CSFRalpha

Feature Type

protein coding gene

Genetic Map

Chromosome 19

56.89 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr19:61224402-61228418 bp, - strand From NCBI annotation of GRCm38   4017 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48406  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Gene Tree: Csf2ra

Human homologs

Human Homolog		CSF2RA, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
NCBI Gene ID		1438
neXtProt AC		NX_P15509
Human Synonyms		CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GMCSFR, GM-CSF-R-alpha, GMR, SMDP4
Human Chr (Location)		XYp22.32 and Yp11.3

Alleles and phenotypes

All alleles(12) : Gene trapped(12)

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Component	integral to membrane, membrane
Function	cytokine receptor activity

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (32)    Tissues (18)   
Theiler Stages: 1, 2, 3, 4, 5, 17, 20, 22, 23, 24, 25, 28

Assay Type	Results
RT-PCR	26
RNase protection	6

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(16) Primer pair(5) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000059326 (Evidence)
Entrez Gene	12982 (Evidence)
UniGene	287228
DFCI	TC1586253
DoTS	DT.101355619, DT.40169944
NIA Mouse Gene Index	U039215
Consensus CDS Project	CCDS29946.1
International Mouse Knockout Project Status	Csf2ra

Sequences

Length	Strain/Species
genomic	12982	NCBI Gene Model | MGI Sequence Detail	4017	C57BL/6J
transcript	NM_009970	RefSeq | MGI Sequence Detail	1850	C57BL/6
polypeptide	Q00941	UniProt | EBI | MGI Sequence Detail	388	Not Applicable

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(3) : SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015321	Interleukin-6 receptor alpha chain, binding
InterPro	IPR003532	Short hematopoietin receptor, family 2, conserved site
Protein Ontology	PR:000001354	granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:11258 Kitamura T, et al., Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5082-6
(Latest) J:152946 Sferruzzi-Perri AN, et al., Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
All references(46)

Other accession IDs

MGD-MRK-2188, MGI:88532