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Csf3
Gene Detail
 Symbol
Name
ID
Csf3
colony stimulating factor 3 (granulocyte)
MGI:1339751
Synonyms Csfg, G-CSF, MGI-IG
Feature Type protein coding gene
Genetic Map
Chromosome 11
62.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr11:98701263-98703629 bp, + strand
From VEGA annotation of GRCm38

  2367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-6
Gene Tree: Csf3

Human
homologs
Human Homolog CSF3, colony stimulating factor 3 (granulocyte)
NCBI Gene ID 1440
neXtProt AC  NX_P09919
Human Synonyms  C17orf33, CSF3OS, GCSF
Human Chr (Location)  17q11.2-q12; chr17:40015361-40017813 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for a targeted null mutation exhibit chronic neutropenia, with severely reduced peripheral blood neutrophil levels, and reduced resistance to Listeria monocytogenes infection. Heterozygotes have intermediate neutrophil levels.
 
Interactions
Csf3 interacts with 97 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to cytokine stimulus, granulocyte differentiation, ...
Component extracellular region, extracellular space
Function cytokine activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (69)    Tissues (40)    Images (1)
Theiler Stages: 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RT-PCR 69
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(5) cDNA(7) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006406 (Evidence)
Ensembl Gene ModelENSMUSG00000038067 (Evidence)
Entrez Gene12985 (Evidence)
UniGene1238
DFCITC1586594
DoTSDT.40158212
NIA Mouse Gene IndexU013308
Consensus CDS ProjectCCDS25360.1
International Mouse Knockout Project StatusCsf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006406 VEGA Gene Model | MGI Sequence Detail 2367 C57BL/6J ±  kb
transcript OTTMUST00000014593 VEGA | MGI Sequence Detail 1413 Not Applicable 
polypeptide OTTMUSP00000006785 VEGA | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003573 Interleukin-6/G-CSF/MGF
Protein Ontology PR:000005932 granulocyte colony-stimulating factor
References (Earliest) J:8031 Nicola NA, et al., Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells. J Cell Physiol. 1985 Aug;124(2):313-21
(Latest) J:201880 Smeets MF, et al., Removal of myeloid cytokines from the cellular environment enhances T-cell development in vitro. Int Immunol. 2013 Oct;25(10):589-99
All references(134)
Other
accession IDs
MGD-MRK-2186, MGI:88530

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory