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Csf3
Gene Detail
Symbol

Name
ID
Csf3
colony stimulating factor 3 (granulocyte)
MGI:1339751
Synonyms
Csfg, G-CSF, MGI-IG
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr11:98701263-98703629 bp, + strand
From VEGA annotation of GRCm38

  2367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CSF3
Protein SuperFamily: interleukin-6
Gene Tree: Csf3

Human
homologs
CSF3, colony stimulating factor 3 (granulocyte)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1440
neXtProt AC: NX_P09919

Human Synonyms: C17orf33, CSF3OS, GCSF

Human Chr (Location): 17q11.2-q12; chr17:40015361-40017813 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Csf3 (1)
Incidental mutations (data from Mutagenetix , CvDC )
 
Homozygotes for a targeted null mutation exhibit chronic neutropenia, with severely reduced peripheral blood neutrophil levels, and reduced resistance to Listeria monocytogenes infection. Heterozygotes have intermediate neutrophil levels.
 
Interactions
Csf3 interacts with 97 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to cytokine stimulus, granulocyte differentiation, ...
Component extracellular region, extracellular space
Function cytokine activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (69)    Tissues (44)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 69
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase csf3 ; ZFIN csf3a, csf3b    NEW 
Molecular
reagents
All nucleic(18) Genomic(5) cDNA(7) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006406 (Evidence)
Ensembl Gene Model ENSMUSG00000038067 (Evidence)
Entrez Gene 12985 (Evidence)
UniGene 1238
DFCI TC1586594
DoTS DT.40158212
NIA Mouse Gene Index U013308
Consensus CDS Project CCDS25360.1
International Mouse Phenotyping Consortium Status Csf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006406 VEGA Gene Model | MGI Sequence Detail 2367 C57BL/6J ±  kb
transcript OTTMUST00000014593 VEGA | MGI Sequence Detail 1413 Not Applicable 
polypeptide OTTMUSP00000006785 VEGA | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003573 Interleukin-6/G-CSF/MGF
Protein Ontology PR:000005932 granulocyte colony-stimulating factor
References
(Earliest) J:8031 Nicola NA, et al., Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells. J Cell Physiol. 1985 Aug;124(2):313-21
(Latest) J:213449 Schuettpelz LG, et al., G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia. 2014 Sep;28(9):1851-60
All references(138)
Other
accession IDs
MGD-MRK-2186, MGI:88530

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory