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Csf3 Gene Detail
Summary
  • Symbol
    Csf3
  • Name
    colony stimulating factor 3 (granulocyte)
  • Synonyms
    Csfg, G-CSF, MGI-IG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339751
    NCBI Gene: 12985
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98592089-98594455 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.45 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339751
protein coding gene Chr11:98591287-98594457 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019069
protein coding gene Chr11:101293820-101298469 (+)
A/J MGP_AJ_G0019037
protein coding gene Chr11:97056860-97059225 (+)
AKR/J MGP_AKRJ_G0019007
protein coding gene Chr11:100066892-100069258 (+)
BALB/cJ MGP_BALBcJ_G0019011
protein coding gene Chr11:97551805-97555095 (+)
C3H/HeJ MGP_C3HHeJ_G0018824
protein coding gene Chr11:100206781-100209163 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019462
protein coding gene Chr11:104378702-104392664 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017094
protein coding gene Chr11:94614371-94616698 (+)
CAST/EiJ MGP_CASTEiJ_G0018378
protein coding gene Chr11:101190429-101194295 (+)
CBA/J MGP_CBAJ_G0018795
protein coding gene Chr11:108745466-108749416 (+)
DBA/2J MGP_DBA2J_G0018903
protein coding gene Chr11:96616165-96618483 (+)
FVB/NJ MGP_FVBNJ_G0018892
protein coding gene Chr11:96126523-96128817 (+)
LP/J MGP_LPJ_G0018973
protein coding gene Chr11:101753614-101756026 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018919
protein coding gene Chr11:108464477-108466786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019502
protein coding gene Chr11:100408634-100413283 (+)
PWK/PhJ MGP_PWKPhJ_G0018149
protein coding gene Chr11:97648377-97650883 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017938
protein coding gene Chr11:100152974-100155350 (+)
WSB/EiJ MGP_WSBEiJ_G0018427
protein coding gene Chr11:100360569-100363909 (+)



Homology
more
  • Human Ortholog
    CSF3, colony stimulating factor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSF3, colony stimulating factor 3
  • Synonyms
    C17orf33, CSF3OS, GCSF
  • Links
    NCBI Gene ID: 1440
    neXtProt AC: NX_P09919
    UniProt: P09919

  • Chr Location
    17q21.1; chr17:40015361-40017813 (+)  GRCh38

Human Diseases
more
  • Diseases
    17 with human CSF3 associations

Human Disease Mouse Models
      
IDs
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IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit chronic neutropenia, with severely reduced peripheral blood neutrophil levels, and reduced resistance to Listeria monocytogenes infection. Heterozygotes have intermediate neutrophil levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038067 Ensembl Gene Model | MGI Sequence Detail 2367 C57BL/6J ±  kb
    transcript ENSMUST00000038886 Ensembl | MGI Sequence Detail 1413 Not Applicable  
    polypeptide ENSMUSP00000037762 Ensembl | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 5
      cDNA 8
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2186, MGI:88530
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 42
    • Earliest
      J:8031 Nicola NA, et al., Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells. J Cell Physiol. 1985 Aug;124(2):313-21
    • Latest
      J:337178 Ioannou M, et al., Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening. Nat Commun. 2022 Aug 9;13(1):4658

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory