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Myh2 Gene Detail
Summary
  • Symbol
    Myh2
  • Name
    myosin, heavy polypeptide 2, skeletal muscle, adult
  • Synonyms
    MHC2A, MyHC-IIa, Myhs-f, Myhsf1, Myhs-f1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339710
    NCBI Gene: 17882
Location & Maps
more
  • Sequence Map
    Chr11:67171066-67197514 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26449 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    MYH2, myosin, heavy chain 2, skeletal muscle, adult
  • Vertebrate Orthologs
    13
  • Human Ortholog
    MYH2, myosin, heavy chain 2, skeletal muscle, adult
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IBM3, MYH2A, MYHas8, MyHC-2A, MyHC-IIa, MYHSA2, MYPOP
  • Links
    NCBI Gene ID: 4620
    neXtProt AC: NX_Q9UKX2

  • Chr Location
    17p13.1; chr17:10521148-10549700 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MYH2 associations

Human Disease Mouse Models
       Myopathy, Proximal, and Ophthalmoplegia; MYPOP   OMIM: 605637
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Myh2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005919 VEGA Gene Model | MGI Sequence Detail 26449 C57BL/6J ±  kb
transcript OTTMUST00000013179 VEGA | MGI Sequence Detail 6018 Not Applicable  
polypeptide OTTMUSP00000006116 VEGA | MGI Sequence Detail 1942 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    210 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR000048 IQ motif, EF-hand binding site
    IPR001609 Myosin head, motor domain
    IPR027401 Myosin-like IQ motif-containing domain
    IPR004009 Myosin, N-terminal, SH3-like
    IPR008989 Myosin S1 fragment, N-terminal
    IPR002928 Myosin tail
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 38
    Genomic 12
    cDNA 19
    Primer pair 7

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12755, MGD-MRK-12756, MGD-MRK-12760, MGI:97263
References
more
  • Summaries
    All 79
    Developmental Gene Expression 32
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:7444 Czosnek H, et al., The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes. EMBO J. 1982;1(11):1299-305
  • Latest
    J:224980 Lee KY, et al., Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory