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Myh2
Gene Detail
Symbol

Name
ID
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
MGI:1339710
Synonyms
MHC2A, MyHC-IIa, Myhs-f, Myhsf1, Myhs-f1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
40.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:67171066-67197514 bp, + strand
From VEGA annotation of GRCm38

  26449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23019  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 7 chicken

HCOP human homology predictions: MYH2
Gene Tree: Myh2

Human
homologs
MYH2, myosin, heavy chain 2, skeletal muscle, adult
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4620
neXtProt AC: NX_Q9UKX2

Human Synonyms: IBM3, MYH2A, MYHas8, MyHC-2A, MyHC-IIa, MYHSA2, MYPOP

Human Chr (Location): 17p13.1; chr17:10521148-10549700 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYH2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Myh2 interacts with 59 markers (Mir23a, Mir23b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process actin-mediated cell contraction, muscle contraction, ...
Component A band, actomyosin contractile ring, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (37)    Tissues (17)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RT-PCR 31
cDNA source data(18)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase myh2    NEW 
Molecular
reagents
All nucleic(38) Genomic(12) cDNA(19) Primer pair(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005919 (Evidence)
Ensembl Gene Model ENSMUSG00000033196 (Evidence)
Entrez Gene 17882 (Evidence)
UniGene 422801
NIA Mouse Gene Index U097271
Consensus CDS Project CCDS24854.2
International Mouse Phenotyping Consortium Status Myh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005919 VEGA Gene Model | MGI Sequence Detail 26449 C57BL/6J ±  kb
transcript OTTMUST00000013179 VEGA | MGI Sequence Detail 6018 Not Applicable 
polypeptide OTTMUSP00000006116 VEGA | MGI Sequence Detail 1942 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(3) UniProt(4)
Polymorphisms
SNPs within 2kb(210 from dbSNP Build 137)    SNPs within 2kb including multiple locations(214)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010826 myosin-2
References
(Earliest) J:7444 Czosnek H, et al., The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes. EMBO J. 1982;1(11):1299-305
(Latest) J:223069 Chal J, et al., Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 2015 Aug 3;
All references(78)
Other
accession IDs
MGD-MRK-12755, MGD-MRK-12756, MGD-MRK-12760, MGI:97263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory