Myh2
Gene Detail

Symbol Name ID

Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult MGI:1339710

Synonyms

MHC2A, MyHC-IIa, Myhs-f, Myhsf1, Myhs-f1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

40.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr11:67171066-67197514 bp, + strand From VEGA annotation of GRCm38   26449 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:75068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Myh2

Human homologs

Human Homolog		MYH2, myosin, heavy chain 2, skeletal muscle, adult
NCBI Gene ID		4620
neXtProt AC		NX_Q9UKX2
Human Synonyms		MYH2A, MYHas8, MyHC-2A, MyHC-IIa, MYHSA2
Human Chr (Location)		17p13.1; chr17:10424465-10453017 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYH2

Alleles and phenotypes

All alleles(4) : Targeted(4)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	muscle contraction, plasma membrane repair, ...
Component	A band, actomyosin contractile ring, ...
Function	actin binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (33)    Tissues (12)    Images (2)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RT-PCR	31

cDNA source data(18)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(12) cDNA(19) Primer pair(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005919 (Evidence)
Ensembl Gene Model	ENSMUSG00000033196 (Evidence)
Entrez Gene	17882 (Evidence)
UniGene	422801
NIA Mouse Gene Index	U097271
Consensus CDS Project	CCDS24854.2
International Mouse Knockout Project Status	Myh2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005919	VEGA Gene Model | MGI Sequence Detail	26449	C57BL/6J
transcript	OTTMUST00000013179	VEGA | MGI Sequence Detail	6018	Not Applicable
polypeptide	OTTMUSP00000006116	VEGA | MGI Sequence Detail	1942	Not Applicable

All sequences(28) RefSeq(3) UniProt(4)

Polymorphisms

SNPs(161 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR015650	Myosin class 1/2/3/4/7/8/13/15
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR004009	Myosin, N-terminal, SH3-like
InterPro	IPR008989	Myosin S1 fragment, N-terminal
InterPro	IPR002928	Myosin tail
Protein Ontology	PR:000010826	myosin-2

References

(Earliest) J:7444 Czosnek H, et al., The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes. EMBO J. 1982;1(11):1299-305
(Latest) J:188916 Brohl D, et al., Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012 Sep 11;23(3):469-81
All references(70)

Other accession IDs

MGD-MRK-12755, MGD-MRK-12756, MGD-MRK-12760, MGI:97263