Myh2 MGI Mouse Gene Detail - MGI:1339710 - myosin, heavy polypeptide 2, skeletal muscle, adult

Symbol

Myh2
Name

myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms

MHC2A, MyHC-IIa, Myhs-f, Myhs-f1, Myhsf1

Feature Type

protein coding gene
IDs

MGI:1339710
NCBI Gene: 17882
Alliance

genome feature page
Transcription Start Sites

3 TSS
Regulated by

Rr194, Rr196, Rr195 (3 regulatory regions)

Sequence Map

Chr11:67061853-67088343 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 40.59 cM
Mapping Data

13 experiments

SNPs within 2kb

845 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339710	protein coding gene	Chr11:67061853-67088343 (+)
129S1/SvImJ	ENSMUSG00200042306	protein coding gene	Chr11:64009304-64035731 (+)
A/J	ENSMUSG00195041839	protein coding gene	Chr11:64029979-64056476 (+)
AKR/J	ENSMUSG00220043821	protein coding gene	Chr11:64146298-64172793 (+)
BALB/cJ	ENSMUSG00180045478	protein coding gene	Chr11:64095816-64122313 (+)
C3H/HeJ	ENSMUSG00175043691	protein coding gene	Chr11:64046277-64072750 (+)
C57BL/6NJ	ENSMUSG00215053847	protein coding gene	Chr11:63830278-63856831 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016522	protein coding gene	Chr11:61885797-61912547 (+)
CAST/EiJ	ENSTCUG00005048402	protein coding gene	Chr11:63577630-63603943 (+)
CBA/J	ENSMUSG00210053289	protein coding gene	Chr11:63900334-63926826 (+)
DBA/2J	ENSMUSG00185043792	protein coding gene	Chr11:64094501-64120998 (+)
FVB/NJ	ENSMUSG00205053717	protein coding gene	Chr11:63993729-64020220 (+)
JF1/MsJ	ENSUMUG00000030174	protein coding gene	Chr11:64494852-64521962 (+)
LP/J	ENSMUSG00230052463	protein coding gene	Chr11:65219732-65246225 (+)
NOD/ShiLtJ	ENSMUSG00190037273	protein coding gene	Chr11:64127275-64154481 (+)
NZO/HlLtJ	ENSMUSG00225045527	protein coding gene	Chr11:67400577-67427005 (+)
PWK/PhJ	ENSLUMG00010045516	protein coding gene	Chr11:64013717-64040161 (+)
SPRET/EiJ	ENSMSPG00010032372	protein coding gene	Chr11:64741957-64769095 (+)
WSB/EiJ	ENSIUOG00005049126	protein coding gene	Chr11:64031375-64057872 (+)

Human Ortholog

MYH2, myosin heavy chain 2

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYH2, myosin heavy chain 2
Synonyms

CMYO6, CMYP6, IBM3, MYH2A, MYHas8, MyHC-2A, MyHC-IIa, MYHSA2
Links

HGNC:7572

NCBI Gene ID: 4620

UniProt: Q9UKX2
Chr Location

17p13.1; chr17:10521148-10549700 (-) GRCh38

MGI Vertebrate Homology

Myh2 stringent orthology
1 human;1 mouse;7 zebrafish
HCOP

vertebrate homology predictions: MYH2
Gene Tree

Myh2

Diseases

2 with human MYH2 associations

				Human Disease	Mouse Models
				congenital myopathy 6 IDs congenital myopathy 6 DOID:0080719 OMIM:605637 ORDO:79091
				inclusion body myositis IDs inclusion body myositis DOID:3429 ICD10CM:G72.41 ICD9CM:359.71 MESH:D018979 NCI:C84786 OMIM:147421 ORDO:611 UMLS_CUI:C0238190

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

7
Genomic Mutations

1 involving Myh2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

112 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

853
Tissues

72
cDNA Data

19
Literature Summary

90

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myh2

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All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS24854.2

Ensembl

ENSMUSG00000033196 (Evidence)
NCBI Gene

17882

			Length	Strain/Species	Flank
genomic	17882	NCBI Gene Model \| MGI Sequence Detail	26491	C57BL/6J	± kb
transcript	NM_001039545	RefSeq \| MGI Sequence Detail	6083	Not Specified
polypeptide	G3UW82	UniProt \| EBI \| MGI Sequence Detail	1942	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010826 myosin-2

(term hierarchy)
InterPro Domains

IPR014751 DNA repair protein XRCC4-like, C-terminal

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain-like

IPR008989 Myosin S1 fragment, N-terminal

IPR004009 Myosin, SH3 domain

IPR002928 Myosin tail

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

G3UW82 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 48

Genomic 12

cDNA 20

Primer pair 16

Antibodies 5

Microarray probesets 3

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MGD-MRK-12755, MGD-MRK-12756, MGD-MRK-12760, MGI:97263

Summaries

All 173

Developmental Gene Expression 90

Gene Ontology 9

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:387191 Yambe S, et al., Divergent temporal control of deltoid tuberosity and limb tendon development by an evolutionarily conserved scleraxis enhancer. Development. 2026 May 15;153(10):dev205325

Myh2 expression regulated by:

Feature	Feature Type	Location	Reference
Rr194, regulatory region 194	locus control region	Chr11:66994497-67036366	J:322002
Rr196, regulatory region 196	enhancer	Chr11:67010416-67012030	J:322002
Rr195, regulatory region 195	enhancer	Chr11:67029517-67036375	J:322002

TSS for Myh2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3524	Chr11:67061837-67061866 (+)	-1 bp
Tssr102158	Chr11:67061885-67061897 (+)	38 bp
Tssr102159	Chr11:67061921-67061938 (+)	77 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24