Gene Expression Literature Summary

• Symbol: Myh2
• Name: myosin, heavy polypeptide 2, skeletal muscle, adult
• ID: MGI:1339710

76 matching records from 76 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E4.5	E5.5	E6.5	E7.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)									1	4	2	1	1	5	3	8	2	7	1	4		4	1	12		1	1	32
In situ RNA (section)																				1		1		1				1
Immunohistochemistry (whole mount)					1	1						1		1
Northern blot	1	1	1	1	1		1	1		1		1		1		1		1		1	1	1		1				1
Western blot								1		1				1		1		1				1	1			1		4
RT-PCR										2					1	1		2	1	1	1	4	1	9		1		17
cDNA clones																												1
RNase protection														1			1								1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Myh2  myosin, heavy polypeptide 2, skeletal muscle, adult   (Synonyms: MHC2A, MyHC-IIa, Myhs-f, Myhsf1, Myhs-f1)
Results	Reference
2	J:287755 Agarwal M, Sharma A, Kumar P, Kumar A, Bharadwaj A, Saini M, Kardon G, Mathew SJ, Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development. Development. 2020 Apr 6;147(7):dev184507
2	J:340418 Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz MB, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M, Embryo model completes gastrulation to neurulation and organogenesis. Nature. 2022 Oct;610(7930):143-153
1*	J:178848 An CI, Dong Y, Hagiwara N, Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev Biol. 2011;11:59
1*	J:181685 Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PM, Guttridge DC, IKKalpha and alternative NF-kappaB regulate PGC-1beta to promote oxidative muscle metabolism. J Cell Biol. 2012 Feb 20;196(4):497-511
1*	J:242061 Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally JR, Shelton JM, Sanchez-Ortiz E, Bassel-Duby R, Olson EN, Control of muscle formation by the fusogenic micropeptide myomixer. Science. 2017 Apr 21;356(6335):323-327
1*	J:273624 Bourgeois JR, Ferland RJ, Loss of the neurodevelopmental Joubert syndrome causing protein, Ahi1, causes motor and muscle development delays independent of central nervous system involvement. Dev Biol. 2019 Apr 1;448(1):36-47
3	J:188916 Brohl D, Vasyutina E, Czajkowski MT, Griger J, Rassek C, Rahn HP, Purfurst B, Wende H, Birchmeier C, Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012 Sep 11;23(3):469-81
2*	J:259848 Chal J, Al Tanoury Z, Oginuma M, Moncuquet P, Gobert B, Miyanari A, Tassy O, Guevara G, Hubaud A, Bera A, Sumara O, Garnier JM, Kennedy L, Knockaert M, Gayraud-Morel B, Tajbakhsh S, Pourquie O, Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development. 2018 Mar 19;145(6):dev157339
2*	J:223069 Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquie O, Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 2015 Sep;33(9):962-9
1*	J:269200 Cong X, Doering J, Grange RW, Jiang H, Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice. Sci Rep. 2016 May 17;6:26194
1	J:246667 Cortez-Toledo O, Schnair C, Sangngern P, Metzger D, Chao LC, Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. PLoS One. 2017;12(2):e0171268
3*	J:216287 Czajkowski MT, Rassek C, Lenhard DC, Brohl D, Birchmeier C, Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle. Dev Biol. 2014 Nov 15;395(2):307-16
1	J:206594 Daou N, Lecolle S, Lefebvre S, della Gaspera B, Charbonnier F, Chanoine C, Armand AS, A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
4	J:322002 Dos Santos M, Backer S, Aurade F, Wong MM, Wurmser M, Pierre R, Langa F, Do Cruzeiro M, Schmitt A, Concordet JP, Sotiropoulos A, Jeffrey Dilworth F, Noordermeer D, Relaix F, Sakakibara I, Maire P, A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes. Nat Commun. 2022 Feb 24;13(1):1039
1	J:345130 Eguchi T, Tezuka T, Watanabe Y, Inoue-Yamauchi A, Sagara H, Ozawa M, Yamanashi Y, Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024 Feb 16;27(2):108997
1	J:56913 Flucher BE, Conti A, Takeshima H, Sorrentino V, Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J Cell Biol. 1999 Aug 9;146(3):621-30
2	J:334108 Flynn CGK, Ginkel PRV, Hubert KA, Guo Q, Hrycaj SM, McDermott AE, Madruga A, Miller AP, Wellik DM, Hox11-expressing interstitial cells contribute to adult skeletal muscle at homeostasis. Development. 2023 Feb 15;150(4):dev201026
1	J:330579 Gambarotto L, Metti S, Chrisam M, Cerqua C, Sabatelli P, Armani A, Zanon C, Spizzotin M, Castagnaro S, Strappazzon F, Grumati P, Cescon M, Braghetta P, Trevisson E, Cecconi F, Bonaldo P, Ambra1 deficiency impairs mitophagy in skeletal muscle. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2211-2224
3*	J:302851 Greschik H, Duteil D, Messaddeq N, Willmann D, Arrigoni L, Sum M, Jung M, Metzger D, Manke T, Gunther T, Schule R, The histone code reader Spin1 controls skeletal muscle development. Cell Death Dis. 2017 Nov 23;8(11):e3173
1*	J:139636 Grifone R, Jarry T, Dandonneau M, Grenier J, Duprez D, Kelly RG, Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos. Dev Dyn. 2008 Sep 24;237(10):3071-3078
4*	J:100572 Hagiwara N, Ma B, Ly A, Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev Dyn. 2005 Oct;234(2):301-11
2*	J:123082 Hagiwara N, Yeh M, Liu A, Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice. Dev Dyn. 2007 Aug;236(8):2062-76
1	J:161382 Heude E, Bouhali K, Kurihara Y, Kurihara H, Couly G, Janvier P, Levi G, Jaw muscularization requires Dlx expression by cranial neural crest cells. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11441-6
4	J:224077 Huang AH, Riordan TJ, Pryce B, Weibel JL, Watson SS, Long F, Lefebvre V, Harfe BD, Stadler HS, Akiyama H, Tufa SF, Keene DR, Schweitzer R, Musculoskeletal integration at the wrist underlies the modular development of limb tendons. Development. 2015 Jul 15;142(14):2431-41
2*	J:238615 Hurren B, Collins JJ, Duxson MJ, Deries M, First Neuromuscular Contact Correlates with Onset of Primary Myogenesis in Rat and Mouse Limb Muscles. PLoS One. 2015;10(7):e0133811
2	J:303008 Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP, Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid. 2017 Apr;27(4):577-586
1	J:253459 Inoue SI, Takahara S, Yoshikawa T, Niihori T, Yanai K, Matsubara Y, Aoki Y, Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 2017 Dec 1;26(23):4715-4727
1	J:108465 Issa LL, Palmer SJ, Guven KL, Santucci N, Hodgson VR, Popovic K, Joya JE, Hardeman EC, MusTRD can regulate postnatal fiber-specific expression. Dev Biol. 2006 May 1;293(1):104-15
5	J:345111 Jacobson KR, Saleh AM, Lipp SN, Tian C, Watson AR, Luetkemeyer CM, Ocken AR, Spencer SL, Kinzer-Ursem TL, Calve S, Extracellular matrix protein composition dynamically changes during murine forelimb development. iScience. 2024 Feb 16;27(2):108838
5	J:60987 Kablar B, Tajbakhsh S, Rudnicki MA, Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent. Development. 2000 Apr;127(8):1627-39
1	J:277814 Kepser LJ, Damar F, De Cicco T, Chaponnier C, Proszynski TJ, Pagenstecher A, Rust MB, CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8397-8402
1	J:245768 Landry-Truchon K, Houde N, Boucherat O, Joncas FH, Dasen JS, Philippidou P, Mansfield JH, Jeannotte L, HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017 Oct 01;144(19):3547-3561
1*	J:199566 Lee AS, Harris J, Bate M, Vijayraghavan K, Fisher L, Tajbakhsh S, Duxson M, Initiation of primary myogenesis in amniote limb muscles. Dev Dyn. 2013 Sep;242(9):1043-55
1	J:274465 Lee HJ, Kao CY, Lin SC, Xu M, Xie X, Tsai SY, Tsai MJ, Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development. Sci Rep. 2017 Jun 9;7(1):3136
1	J:224980 Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR, Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054
1	J:201148 Lee YS, Lee SJ, Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
1*	J:268425 Li Z, Parlakian A, Coletti D, Alonso-Martin S, Hourde C, Joanne P, Gao-Li J, Blanc J, Ferry A, Paulin D, Xue Z, Agbulut O, Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(Pt 21):4589-601
1	J:317555 Liu KX, Edwards B, Lee S, Finelli MJ, Davies B, Davies KE, Oliver PL, Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain. 2015 May;138(Pt 5):1167-81
10	J:58904 Lu BD, Allen DL, Leinwand LA, Lyons GE, Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development. Dev Biol. 1999 Dec 1;216(1):312-26
1	J:274906 McGlinn E, Holzman MA, Mansfield JH, Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections. Methods Mol Biol. 2019;1920:183-218
13	J:125838 Merrick D, Ting T, Stadler LK, Smith J, A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre. BMC Dev Biol. 2007;7:65
1*	J:200444 Millay DP, O'Rourke JR, Sutherland LB, Bezprozvannaya S, Shelton JM, Bassel-Duby R, Olson EN, Myomaker is a membrane activator of myoblast fusion and muscle formation. Nature. 2013 Jul 18;499(7458):301-5
4	J:100019 Oh M, Rybkin II, Copeland V, Czubryt MP, Shelton JM, van Rooij E, Richardson JA, Hill JA, De Windt LJ, Bassel-Duby R, Olson EN, Rothermel BA, Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol. 2005 Aug;25(15):6629-38
1	J:162164 Otto A, Macharia R, Matsakas A, Valasek P, Mankoo BS, Patel K, A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity. Dev Biol. 2010 Jul 1;343(1-2):51-62
1	J:263801 Papizan JB, Vidal AH, Bezprozvannaya S, Bassel-Duby R, Olson EN, Cullin-3-RING ubiquitin ligase activity is required for striated muscle function in mice. J Biol Chem. 2018 Jun 8;293(23):8802-8811
1*	J:304043 Parente A, Boukredine A, Baraige F, Duprat N, Gondran-Tellier V, Magnol L, Blanquet V, GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics. FASEB J. 2020 Mar;34(3):4026-4040
3	J:1896 Parker-Thornburg J, Bauer B, Palermo J, Robbins J, Structural and developmental analysis of two linked myosin heavy chain genes. Dev Biol. 1992 Mar;150(1):99-107
1	J:305082 Pathak P, Blech-Hermoni Y, Subedi K, Mpamugo J, Obeng-Nyarko C, Ohman R, Molloy I, Kates M, Hale J, Stauffer S, Sharan SK, Mankodi A, Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCalpha and TSC2-mTOR downregulation. Commun Biol. 2021 Mar 19;4(1):355
2	J:212185 Petchey LK, Risebro CA, Vieira JM, Roberts T, Bryson JB, Greensmith L, Lythgoe MF, Riley PR, Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9515-20
2	J:178379 Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P, Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
1*	J:267665 Rubio-Solsona E, Marti S, Vilchez JJ, Palau F, Hoenicka J, ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism. PLoS One. 2018;13(5):e0197254
3	J:226889 Sakakibara I, Santolini M, Ferry A, Hakim V, Maire P, Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. PLoS Genet. 2014;10(5):e1004386
3	J:270627 Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P, Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skelet Muscle. 2016;6(1):30
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1*	J:166500 Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard JC, Agarkova I, Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008 Feb 15;376(2):338-51
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1	J:239455 Shin J, Watanabe S, Hoelper S, Kruger M, Kostin S, Poling J, Kubin T, Braun T, BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife. 2016 Dec 01;5:e18351
1	J:239493 Sigoillot SM, Bourgeois F, Karmouch J, Molgo J, Dobbertin A, Chevalier C, Houlgatte R, Leger J, Legay C, Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency. FASEB J. 2016 Jun;30(6):2382-99
1*	J:203329 Siles L, Sanchez-Tillo E, Lim JW, Darling DS, Kroll KL, Postigo A, ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression. Mol Cell Biol. 2013 Apr;33(7):1368-82
2	J:32187 Smith TH, Miller JB, Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro. Dev Biol. 1992 Jan;149(1):16-26
1	J:230727 Stark DA, Coffey NJ, Pancoast HR, Arnold LL, Walker JP, Vallee J, Robitaille R, Garcia ML, Cornelison DD, Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol. 2015 Dec 7;211(5):1077-91
3	J:278534 Takahashi M, Tamura M, Sato S, Kawakami K, Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele. Dis Model Mech. 2018 Oct 25;11(10):dmm034611
1*	J:308975 Takenoshita M, Takechi M, Vu Hoang T, Furutera T, Akagawa C, Namangkalakul W, Aoto K, Kume T, Miyashin M, Iwamoto T, Iseki S, Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development. Dev Dyn. 2021 Aug;250(8):1125-1139
4*	J:85709 Usami A, Abe S, Ide Y, Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development. Anat Histol Embryol. 2003 Aug;32(4):244-8
3*	J:61155 Valdez MR, Richardson JA, Klein WH, Olson EN, Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. Dev Biol. 2000 Mar 15;219(2):287-98
1*	J:155756 van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN, A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009 Nov;17(5):662-73
16	J:103000 Watanabe R, Chano T, Inoue H, Isono T, Koiwai O, Okabe H, Rb1cc1 is critical for myoblast differentiation through Rb1 regulation. Virchows Arch. 2005 Sep;447(3):643-8
1*	J:270838 Wiederstein JL, Nolte H, Gunther S, Piller T, Baraldo M, Kostin S, Bloch W, Schindler N, Sandri M, Blaauw B, Braun T, Holper S, Kruger M, Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep. 2018 May 1;23(5):1342-1356
1*	J:136573 Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA, Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008 Apr 25;283(17):11850-9
3	J:342003 Xiao S, Zhang W, Li J, Manley NR, Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells. Front Immunol. 2023;14:1261081
1	J:306954 Zecchini S, Giovarelli M, Perrotta C, Morisi F, Touvier T, Di Renzo I, Moscheni C, Bassi MT, Cervia D, Sandri M, Clementi E, De Palma C, Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism. Autophagy. 2019 Jan;15(1):58-77
2	J:26105 Zhang W, Behringer RR, Olson EN, Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 1995 Jun 1;9(11):1388-99
1	J:344238 Zheng Y, Zhao C, Song Q, Xu L, Zhang B, Hu G, Kong X, Li S, Li X, Shen Y, Zhuang L, Wu M, Liu Y, Zhou Y, Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities. Cell Rep. 2023 Dec 26;42(12):113496