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Neurod1
Gene Detail
Symbol

Name
ID
Neurod1
neurogenic differentiation 1
MGI:1339708
Synonyms
BETA2, bHLHa3, Neurod
Feature Type
protein coding gene
Genetic Map
Chromosome 2
47.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:79452521-79456751 bp, - strand
From VEGA annotation of GRCm38

  4231 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NEUROD1
Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod1

Human
homologs
NEUROD1, neuronal differentiation 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4760
neXtProt AC: NX_Q13562

Human Synonyms: BETA2, BHF-1, bHLHa3, MODY6, NEUROD

Human Chr (Location): 2q32; chr2:181676106-181680665 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NEUROD1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Neurod1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit neonatal diabetes, pancreatic enteroendocrine cell deficits, impaired hearing and balance, retinal degeneration, and seizures. Survival past birth is dependent on genetic background.
 
Human Diseases Modeled in Mice Using Neurod1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Neurod1 interacts with 241 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process amacrine cell differentiation, anterior/posterior pattern specification, ...
Component cytoplasm, intracellular, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (308 records)
Data Summary: Results (837)    Tissues (344)    Images (228)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 54
RNA in situ 642
In situ reporter (knock in) 10
Northern blot 53
Western blot 2
RT-PCR 76
cDNA source data(43)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NEUROD1 ; Xenbase neurod1 ; ZFIN neurod1    NEW 
Molecular
reagents
All nucleic(72) Genomic(1) cDNA(47) Primer pair(13) Other(11)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000013310 (Evidence)
Ensembl Gene Model ENSMUSG00000034701 (Evidence)
Entrez Gene 18012 (Evidence)
UniGene 4636
DFCI TC1579116, TC1595669
NIA Mouse Gene Index U022794
PDB 2QL2
Consensus CDS Project CCDS16169.1
International Mouse Phenotyping Consortium Status Neurod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013310 VEGA Gene Model | MGI Sequence Detail 4231 C57BL/6J ±  kb
transcript OTTMUST00000032176 VEGA | MGI Sequence Detail 2729 Not Applicable 
polypeptide OTTMUSP00000014302 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR022575 Neurogenic differentiation factor, domain of unknown function
InterPro IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology PR:000011152 neurogenic differentiation factor 1
References
(Earliest) J:25296 Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
(Latest) J:220744 Xu EE, et al., SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
All references(379)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-26011, MGI:104577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory