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Neurod1
Gene Detail
 Symbol
Name
ID
Neurod1
neurogenic differentiation 1
MGI:1339708
Synonyms BETA2, bHLHa3, Neurod
Feature Type protein coding gene
Genetic Map
Chromosome 2
47.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:79452521-79456751 bp, - strand
From VEGA annotation of GRCm38

  4231 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod1

Human
homologs
Human Homolog NEUROD1, neuronal differentiation 1
NCBI Gene ID 4760
neXtProt AC  NX_Q13562
Human Synonyms  BETA2, BHF-1, bHLHa3, MODY6, NEUROD
Human Chr (Location)  2q32; chr2:181676106-181680665 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NEUROD1
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Homozygotes for targeted null mutations exhibit neonatal diabetes, pancreatic enteroendocrine cell deficits, impaired hearing and balance, retinal degeneration, and seizures. Survival past birth is dependent on genetic background.
 
Human Diseases Modeled Using Mouse Neurod1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process amacrine cell differentiation, anterior/posterior pattern specification, ...
Component cytoplasm, intracellular, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (277 records)
Data Summary: Results (805)    Tissues (328)    Images (184)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 32
RNA in situ 637
In situ reporter (knock in) 10
Northern blot 53
Western blot 2
RT-PCR 71
cDNA source data(43)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(70) Genomic(1) cDNA(47) Primer pair(12) Other(10)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000013310 (Evidence)
Ensembl Gene ModelENSMUSG00000034701 (Evidence)
Entrez Gene18012 (Evidence)
UniGene4636
DFCITC1579116, TC1595669
NIA Mouse Gene IndexU022794
PDB2QL2
Consensus CDS ProjectCCDS16169.1
International Mouse Knockout Project StatusNeurod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013310 VEGA Gene Model | MGI Sequence Detail 4231 C57BL/6J ±  kb
transcript OTTMUST00000032176 VEGA | MGI Sequence Detail 2729 Not Applicable 
polypeptide OTTMUSP00000014302 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR022575 Neurogenic differentiation factor, domain of unknown function
InterPro IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology PR:000011152 neurogenic differentiation factor 1
References (Earliest) J:25296 Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
(Latest) J:205567 Li K, et al., Shp2-Dependent ERK Signaling Is Essential for Induction of Bergmann Glia and Foliation of the Cerebellum. J Neurosci. 2014 Jan 15;34(3):922-31
All references(343)
Other
accession IDs
MGD-MRK-26011, MGI:104577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory