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Neurod1 Gene Detail
Summary
  • Symbol
    Neurod1
  • Name
    neurogenic differentiation 1
  • Synonyms
    BETA2, bHLHa3, Nd1, Neurod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339708
    NCBI Gene: 18012
  • Gene Overview
    MyGene.info: NEUROD1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79452641-79456636 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 47.58 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339708
protein coding gene Chr2:79452521-79456751 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025878
protein coding gene Chr2:80000694-80004926 (-)
A/J MGP_AJ_G0025855
protein coding gene Chr2:76911591-76915820 (-)
AKR/J MGP_AKRJ_G0025824
protein coding gene Chr2:78915267-78919497 (-)
BALB/cJ MGP_BALBcJ_G0025851
protein coding gene Chr2:77033379-77037608 (-)
C3H/HeJ MGP_C3HHeJ_G0025610
protein coding gene Chr2:79143923-79148152 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026297
protein coding gene Chr2:82373609-82377839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023700
protein coding gene Chr2:74156948-74161185 (-)
CAST/EiJ MGP_CASTEiJ_G0025072
protein coding gene Chr2:79565690-79569921 (-)
CBA/J MGP_CBAJ_G0025591
protein coding gene Chr2:85337665-85341894 (-)
DBA/2J MGP_DBA2J_G0025722
protein coding gene Chr2:76456472-76464180 (-)
FVB/NJ MGP_FVBNJ_G0025684
protein coding gene Chr2:75827847-75832078 (-)
LP/J MGP_LPJ_G0025810
protein coding gene Chr2:79850946-79855175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025715
protein coding gene Chr2:87171618-87176247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026353
protein coding gene Chr2:79089095-79093326 (-)
PWK/PhJ MGP_PWKPhJ_G0024815
protein coding gene Chr2:76403816-76408080 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024621
protein coding gene Chr2:79350771-79354995 (-)
WSB/EiJ MGP_WSBEiJ_G0025141
protein coding gene Chr2:79719576-79723806 (-)



Homology
more
  • Human Ortholog
    NEUROD1, neuronal differentiation 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEUROD1, neuronal differentiation 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BETA2, BHF-1, bHLHa3, MODY6, NEUROD
  • Links
    NCBI Gene ID: 4760
    neXtProt AC: NX_Q13562
    UniProt: Q13562

  • Chr Location
    2q31.3; chr2:181676106-181680665 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Neurod1 mouse models; 2 with human NEUROD1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 7 alleles in 11 genetic backgrounds
    32 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit neonatal diabetes, pancreatic enteroendocrine cell deficits, impaired hearing and balance, retinal degeneration, and seizures. Survival past birth is dependent on genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18012 NCBI Gene Model | MGI Sequence Detail 3996 C57BL/6J ±  kb
    transcript NM_010894 RefSeq | MGI Sequence Detail 2510 C57BL/6  
    polypeptide Q60867 UniProt | EBI | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011152 neurogenic differentiation factor 1
    • PDB
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032652 Neurogenic differentiation factor 1
      IPR022575 Neurogenic differentiation factor, domain of unknown function
      IPR016637 Neurogenic differentiation factor NeuroD
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 1
      cDNA 50
      Primer pair 15
      Other 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26011, MGI:104577
    References
    more
    • Summaries
      All 463
      Developmental Gene Expression 371
      Diseases 1
      Gene Ontology 28
      Phenotypes 48
    • Earliest
      J:25296 Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
    • Latest
      J:265671 Gorelik A, et al., Complement C3 Affects Rac1 Activity in the Developing Brain. Front Mol Neurosci. 2018;11:150

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory