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Neurod1 Gene Detail
Summary
  • Symbol
    Neurod1
  • Name
    neurogenic differentiation 1
  • Synonyms
    BETA2, bHLHa3, Nd1, Neurod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339708
    NCBI Gene: 18012
  • Gene Overview
    MyGene.info: NEUROD1
Location & Maps
more
  • Sequence Map
    Chr2:79452521-79456751 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4231 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 47.58 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NEUROD1, neuronal differentiation 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEUROD1, neuronal differentiation 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BETA2, BHF-1, bHLHa3, MODY6, NEUROD
  • Links
    NCBI Gene ID: 4760
    neXtProt AC: NX_Q13562

  • Chr Location
    2q31.3; chr2:181676106-181680665 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Neurod1 mouse models; 2 with human NEUROD1 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent, 7; IDDM7   OMIM: 600321 View 1 model
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853
Maturity-Onset Diabetes of the Young, Type 6; MODY6   OMIM: 606394
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 6 alleles in 10 genetic backgrounds
    32 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Targeted
    9
  • Transgenic
    1
  • Genomic Mutations
    3 involving Neurod1
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit neonatal diabetes, pancreatic enteroendocrine cell deficits, impaired hearing and balance, retinal degeneration, and seizures. Survival past birth is dependent on genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013310 VEGA Gene Model | MGI Sequence Detail 4231 C57BL/6J ±  kb
transcript OTTMUST00000032176 VEGA | MGI Sequence Detail 2729 Not Applicable  
polypeptide OTTMUSP00000014302 VEGA | MGI Sequence Detail 357 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    25 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011152 neurogenic differentiation factor 1
  • PDB
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032652 Neurogenic differentiation factor 1
    IPR022575 Neurogenic differentiation factor, domain of unknown function
    IPR016637 Neurogenic differentiation factor NeuroD
Molecular
Reagents
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  • All nucleic 73
    Genomic 1
    cDNA 47
    Primer pair 14
    Other 11

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-26011, MGI:104577
References
more
  • Summaries
    All 400
    Developmental Gene Expression 329
    Diseases 2
    Gene Ontology 28
    Phenotypes 43
  • Earliest
    J:25296 Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
  • Latest
    J:235721 Menuchin-Lasowski Y, et al., Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals. Development. 2016 Aug 1;143(15):2829-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory