Neurod1
Gene Detail

Symbol Name ID

Neurod1 neurogenic differentiation 1 MGI:1339708

Synonyms

BETA2, bHLHa3, Neurod

Feature Type

protein coding gene

Genetic Map

Chromosome 2

47.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:79452521-79456751 bp, - strand From VEGA annotation of GRCm38   4231 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod1

Human homologs

Human Homolog		NEUROD1, neuronal differentiation 1
NCBI Gene ID		4760
neXtProt AC		NX_Q13562
Human Synonyms		BETA2, BHF-1, bHLHa3, MODY6, NEUROD
Human Chr (Location)		2q32; chr2:182540833-182545392 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human NEUROD1

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for targeted null mutations exhibit neonatal diabetes, pancreatic enteroendocrine cell deficits, impaired hearing and balance, retinal degeneration, and seizures. Survival past birth is dependent on genetic background.

 
Human Diseases Modeled Using Mouse Neurod1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (69 annotations)

Process	amacrine cell differentiation, anterior/posterior pattern specification, ...
Component	cytoplasm, intracellular, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (258 records)
Data Summary: Results (766)    Tissues (318)    Images (158)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	25
RNA in situ	615
Northern blot	53
Western blot	2
RT-PCR	71

cDNA source data(45)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(72) Genomic(1) cDNA(49) Primer pair(12) Other(10)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000013310 (Evidence)
Ensembl Gene Model	ENSMUSG00000034701 (Evidence)
Entrez Gene	18012 (Evidence)
UniGene	4636
DFCI	TC1579116, TC1595669
NIA Mouse Gene Index	U022794
PDB	2QL2
Consensus CDS Project	CCDS16169.1
International Mouse Knockout Project Status	Neurod1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013310	VEGA Gene Model | MGI Sequence Detail	4231	C57BL/6J
transcript	OTTMUST00000032176	VEGA | MGI Sequence Detail	2729	Not Applicable
polypeptide	OTTMUSP00000014302	VEGA | MGI Sequence Detail	357	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR022575	Neurogenic differentiation factor, domain of unknown function
InterPro	IPR016637	Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology	PR:000011152	neurogenic differentiation factor 1

References

(Earliest) J:25296 Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
(Latest) J:194077 Mao CA, et al., Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7. Development. 2013 Feb 1;140(3):541-51
All references(323)

Other accession IDs

MGD-MRK-26011, MGI:104577