About   Help   FAQ
Muc2 Gene Detail
Summary
  • Symbol
    Muc2
  • Name
    mucin 2
  • Synonyms
    2010015E03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339364
    NCBI Gene: 17831
  • Gene Overview
    MyGene.info: MUC2
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141690340-141754693 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.10 cM, cytoband F5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339364
protein coding gene Chr7:141690340-141754694 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033240
protein coding gene Chr7:146900982-146935561 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033734
protein coding gene Chr7:152261356-152297828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030707
protein coding gene Chr7:143896091-143925064 (+)
CAST/EiJ MGP_CASTEiJ_G0032267
protein coding gene Chr7:138720754-138754778 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0033156
protein coding gene Chr7:148390207-148421820 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0033753
protein coding gene Chr7:145616050-145648240 (+)
PWK/PhJ MGP_PWKPhJ_G0031971
protein coding gene Chr7:133930187-133961216 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032377
protein coding gene Chr7:146575415-146608092 (+)



Homology
more
  • Human Ortholog
    MUC2, mucin 2, oligomeric mucus/gel-forming
  • Vertebrate Orthologs
    3
  • Human Ortholog
    MUC2, mucin 2, oligomeric mucus/gel-forming
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MLP, MUC-2, SMUC
  • Links
    NCBI Gene ID: 4583
    UniProt: Q02817

  • Chr Location
    11p15.5; chr11:1074875-1110508 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Muc2 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 7 alleles in 8 genetic backgrounds
    8 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a point mutation have soft feces at weaning and develop diarrhea associated with malapsorption syndrome. Homozygous null mutants pass blood in their feces at 6 months, and 65% of null mutants have intestinal tumors at 1 year.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025515 Ensembl Gene Model | MGI Sequence Detail 64354 C57BL/6J ±  kb
    transcript ENSMUST00000187945 Ensembl | MGI Sequence Detail 2926 Not Applicable  
    polypeptide ENSMUSP00000141128 Ensembl | MGI Sequence Detail 923 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 3
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917597, MGI:3584408
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 23
      Diseases 2
      Gene Ontology 9
      Phenotypes 34
    • Earliest
      J:52364 van Klinken BJ, et al., Gastrointestinal expression and partial cDNA cloning of murine Muc2. Am J Physiol. 1999 Jan;276(1 Pt 1):G115-24
    • Latest
      J:263836 Srivillibhuthur M, et al., TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol. 2018 Jul 15;439(2):92-101

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory