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Padi4
Gene Detail
Symbol

Name
ID
Padi4
peptidyl arginine deiminase, type IV
MGI:1338898
Synonyms
Pad4, PAD type IV, Pdi4
Feature Type
protein coding gene
Genetic Map
Chromosome 4
72.34 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:140745865-140774236 bp, - strand
From VEGA annotation of GRCm38

  28372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PADI4
Protein SuperFamily: protein-arginine deiminase
Gene Tree: Padi4

Human
homologs
PADI4, peptidyl arginine deiminase, type IV
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23569
neXtProt AC: NX_Q9UM07

Human Synonyms: PAD, PAD4, PADI5, PDI4, PDI5

Human Chr (Location): 1p36.13; chr1:17308195-17364004 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PADI4

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Genomic Mutations involving Padi4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice are viable albeit reduced number than expected were born from heterozygous crosses, and shows decreased antibacterial immune responses. Mice homozygous for a different knock-out allele exhibit decreased weight loss in response to viral infection.
 
Interactions
Padi4 interacts with 52 markers (Mir18, Mir18b, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process chromatin modification, chromatin remodeling, ...
Component cytoplasm, nucleus
Function arginine deiminase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010033 (Evidence)
Ensembl Gene Model ENSMUSG00000025330 (Evidence)
Entrez Gene 18602 (Evidence)
UniGene 250358
DFCI TC1582660, TC1642586, TC1685027
DoTS DT.101355072, DT.488765
NIA Mouse Gene Index U041418
EC 3.5.3.15
Consensus CDS Project CCDS18854.1
International Mouse Phenotyping Consortium Status Padi4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010033 VEGA Gene Model | MGI Sequence Detail 28372 C57BL/6J ±  kb
transcript OTTMUST00000023349 VEGA | MGI Sequence Detail 2316 Not Applicable 
polypeptide OTTMUSP00000010675 VEGA | MGI Sequence Detail 666 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(268 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR004303 Protein-arginine deiminase
InterPro IPR013530 Protein-arginine deiminase, C-terminal
InterPro IPR013733 Protein-arginine deiminase (PAD), central domain
InterPro IPR013732 Protein-arginine deiminase (PAD) N-terminal
Protein Ontology PR:000012222 protein-arginine deiminase type-4
References
(Earliest) J:53035 Rus'd AA, et al., Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse. Eur J Biochem. 1999 Feb;259(3):660-9
(Latest) J:221976 Rosilio C, et al., L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia. Leukemia. 2015 Jun;29(6):1253-66
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory