Padi4
Gene Detail

Symbol Name ID

Padi4 peptidyl arginine deiminase, type IV MGI:1338898

Synonyms

Pad4, PAD type IV, Pdi4

Feature Type

protein coding gene

Genetic Map

Chromosome 4

72.34 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:140745865-140774236 bp, - strand From VEGA annotation of GRCm38   28372 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: protein-arginine deiminase
Gene Tree: Padi4

Human homologs

Human Homolog		PADI4, peptidyl arginine deiminase, type IV
NCBI Gene ID		23569
neXtProt AC		NX_Q9UM07
Human Synonyms		PAD, PAD4, PADI5, PDI4, PDI5
Human Chr (Location)		1p36.13; chr1:17634690-17690495 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PADI4

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Homozygous mice are viable albeit reduced number than expected were born from heterozygous crosses, and shows decreased antibacterial immune responses. Mice homozygous for a different knock-out allele exhibit decreased weight loss in response to viral infection.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cellular protein modification process, chromatin modification, ...
Component	cytoplasm, nucleus
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010033 (Evidence)
Ensembl Gene Model	ENSMUSG00000025330 (Evidence)
Entrez Gene	18602 (Evidence)
UniGene	250358
DFCI	TC1582660, TC1642586, TC1685027
DoTS	DT.101355072, DT.488765
NIA Mouse Gene Index	U041418
EC	3.5.3.15
Consensus CDS Project	CCDS18854.1
International Mouse Knockout Project Status	Padi4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010033	VEGA Gene Model | MGI Sequence Detail	28372	C57BL/6J
transcript	OTTMUST00000023349	VEGA | MGI Sequence Detail	2316	Not Applicable
polypeptide	OTTMUSP00000010675	VEGA | MGI Sequence Detail	666	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008972	Cupredoxin
InterPro	IPR004303	Protein-arginine deiminase
InterPro	IPR013530	Protein-arginine deiminase, C-terminal
InterPro	IPR013733	Protein-arginine deiminase (PAD), central domain
InterPro	IPR013732	Protein-arginine deiminase (PAD) N-terminal
InterPro	IPR016296	Protein-arginine deiminase, subgroup
Protein Ontology	PR:000012222	protein-arginine deiminase type-4

References

(Earliest) J:53035 Rus'd AA, et al., Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse. Eur J Biochem. 1999 Feb;259(3):660-9
(Latest) J:190651 Arandjelovic S, et al., ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor. J Immunol. 2012 Oct 15;189(8):4112-22
All references(36)