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Uhrf1
Gene Detail
 Symbol
Name
ID
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
MGI:1338889
Synonyms ICBP90, Np95
Feature Type protein coding gene
Genetic Map
Chromosome 17
29.26 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:56303321-56323486 bp, + strand
From VEGA annotation of GRCm38

  20166 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Uhrf1

Human
homologs
Human Homolog UHRF1, ubiquitin-like with PHD and ring finger domains 1
NCBI Gene ID 29128
neXtProt AC  NX_Q96T88
Human Synonyms  hNP95, hUHRF1, huNp95, ICBP90, Np95, RNF106
Human Chr (Location)  19p13.3; chr19:4909498-4962154 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(24) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous fordisruption of this marker die early in gestation showing growth retardation and various malformations.
 
Interactions
Uhrf1 interacts with 132 markers (Mir7-1, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process cell cycle, cell proliferation, ...
Component euchromatin, heterochromatin, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (484)    Tissues (222)    Images (36)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 18, 19, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 473
RT-PCR 11
cDNA source data(236)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(239) cDNA(237) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021035 (Evidence)
Ensembl Gene ModelENSMUSG00000001228 (Evidence)
Entrez Gene18140 (Evidence)
UniGene42196
DFCITC1573216, TC1640288, TC1729024
DoTSDT.101184854, DT.101394115, DT.102557789, DT.110568182, DT.531257, DT.97377095
EC6.3.2.-
PDB2ZKD, 2ZKE, 2ZKF, 2ZKG, 3F8I, 3F8J, 3FDE, 2ZO0, 2ZO1, 2ZO2
Consensus CDS ProjectCCDS28903.1, CCDS50151.1
International Mouse Knockout Project StatusUhrf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021035 VEGA Gene Model | MGI Sequence Detail 20166 C57BL/6J ±  kb
transcript OTTMUST00000049736 VEGA | MGI Sequence Detail 3586 Not Applicable 
polypeptide OTTMUSP00000023097 VEGA | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021991 Domain of unknown function DUF3590
InterPro IPR015947 PUA-like domain
InterPro IPR014722 Ribosomal protein L2 domain 2
InterPro IPR003105 SRA-YDG
InterPro IPR000626 Ubiquitin
InterPro IPR019956 Ubiquitin subgroup
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000017070 E3 ubiquitin-protein ligase UHRF1
References (Earliest) J:52005 Fujimori A, et al., Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation. Mamm Genome. 1998 Dec;9(12):1032-5
(Latest) J:213030 Bashtrykov P, et al., The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. J Biol Chem. 2014 Feb 14;289(7):4106-15
All references(57)
Other
accession IDs
MGI:2146950

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory