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Uhrf1 Gene Detail
Summary
  • Symbol
    Uhrf1
  • Name
    ubiquitin-like, containing PHD and RING finger domains, 1
  • Synonyms
    ICBP90, Np95
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338889
    NCBI Gene: 18140
  • Gene Overview
    MyGene.info: UHRF1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56303337-56323486 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.26 cM, cytoband D-E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338889
protein coding gene Chr17:56303321-56323486 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023924
protein coding gene Chr17:57987757-58006428 (+)
A/J MGP_AJ_G0023882
protein coding gene Chr17:56401996-56421742 (+)
AKR/J MGP_AKRJ_G0023851
protein coding gene Chr17:57093089-57121148 (+)
BALB/cJ MGP_BALBcJ_G0023883
protein coding gene Chr17:56224133-56244277 (+)
C3H/HeJ MGP_C3HHeJ_G0023647
protein coding gene Chr17:57802749-57836776 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024329
protein coding gene Chr17:60255404-60282819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021775
protein coding gene Chr17:52890872-52910115 (+)
CAST/EiJ MGP_CASTEiJ_G0023129
protein coding gene Chr17:58103790-58127456 (+)
CBA/J MGP_CBAJ_G0023623
protein coding gene Chr17:62586899-62613374 (+)
DBA/2J MGP_DBA2J_G0023751
protein coding gene Chr17:55112343-55131109 (+)
FVB/NJ MGP_FVBNJ_G0023717
protein coding gene Chr17:54641951-54662262 (+)
LP/J MGP_LPJ_G0023833
protein coding gene Chr17:58670240-58690802 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023745
protein coding gene Chr17:62100268-62121295 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024373
protein coding gene Chr17:57461814-57483210 (+)
PWK/PhJ MGP_PWKPhJ_G0022875
protein coding gene Chr17:54461164-54484395 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022686
protein coding gene Chr17:54216616-54239542 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    UHRF1, ubiquitin like with PHD and ring finger domains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UHRF1, ubiquitin like with PHD and ring finger domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hNP95, hUHRF1, huNp95, ICBP90, Np95, RNF106, TDRD22
  • Links
    NCBI Gene ID: 29128
    neXtProt AC: NX_Q96T88
    UniProt: Q96T88

  • Chr Location
    19p13.3; chr19:4903080-4962154 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7866
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UHRF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this marker die early in gestation showing growth retardation and various malformations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18140 NCBI Gene Model | MGI Sequence Detail 20150 C57BL/6J ±  kb
    transcript NM_010931 RefSeq | MGI Sequence Detail 3583 C57BL/6  
    polypeptide Q8VDF2 UniProt | EBI | MGI Sequence Detail 782 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 240
      cDNA 238
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146950
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 12
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:52005 Fujimori A, et al., Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation. Mamm Genome. 1998 Dec;9(12):1032-5
    • Latest
      J:261586 Chen C, et al., Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection. J Exp Med. 2018 May 7;215(5):1437-1448

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory