Sequence Detail

ID/Version

Q8VDF2 Q8VIA1 Q3ULF2 Q3U9P2 Q8C6F1 Q3U9D7 Q3ULQ0 Q3UI74 Q3UIE6 Q9Z1H6 (UniProt | EBI)

Last sequence update: 2005-06-07
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase UHRF1; EC=2.3.2.27;AltName: Full=Nuclear protein 95;AltName: Full=Nuclear zinc finger protein Np95;AltName: Full=RING-type E3 ubiquitin transferase UHRF1;AltName: Full=Ubiquitin-like PHD and RING finger do

Provider

SWISS-PROT

Sequence

Polypeptide 782 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	56	110	3	32

Sequence references in MGI

J:52005 Fujimori A, et al., Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation. Mamm Genome. 1998 Dec;9(12):1032-5
J:89061 Citterio E, et al., Np95 is a histone-binding protein endowed with ubiquitin ligase activity. Mol Cell Biol. 2004 Mar;24(6):2526-35
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:129097 Sharif J, et al., The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature. 2007 Dec 6;450(7171):908-12
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:161259 Meilinger D, et al., Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep. 2009 Nov;10(11):1259-64
J:173043 Kim JK, et al., UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 2009 Feb;37(2):493-505
J:188893 Qin W, et al., Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J Cell Biochem. 2011 Feb;112(2):439-44
J:188898 Bostick M, et al., UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science. 2007 Sep 21;317(5845):1760-4
J:190276 Nady N, et al., Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J Biol Chem. 2011 Jul 8;286(27):24300-11
J:243489 Graf U, et al., Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nat Cell Biol. 2017 Jul;19(7):763-773
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:342936 Uemura T, et al., Temporal and spatial localization of novel nuclear protein NP95 in mitotic and meiotic cells. Cell Struct Funct. 2000 Jun;25(3):149-59