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Bmp10 Gene Detail
Summary
  • Symbol
    Bmp10
  • Name
    bone morphogenetic protein 10
  • Synonyms
    b2b2711Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338820
    NCBI Gene: 12154
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87405976-87411494 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.96 cM, cytoband D2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338820
 protein coding gene Chr6:87405976-87414659 (+)
129S1/SvImJ ENSMUSG00200041959
 protein coding gene Chr6:84340249-84348977 (+)
A/J ENSMUSG00195038773
 protein coding gene Chr6:84043401-84052137 (+)
AKR/J ENSMUSG00220033536
 protein coding gene Chr6:82953704-82962479 (+)
BALB/cJ ENSMUSG00180014736
 protein coding gene Chr6:84426898-84435669 (+)
C3H/HeJ ENSMUSG00175036808
 protein coding gene Chr6:92972239-92980965 (-)
C57BL/6NJ ENSMUSG00215029596
 protein coding gene Chr6:84432362-84441129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028612
 protein coding gene Chr6:83525708-83535416 (+)
CAST/EiJ ENSTCUG00005016957
 protein coding gene Chr6:84363602-84372299 (+)
CBA/J ENSMUSG00210042883
 protein coding gene Chr6:84239479-84248201 (+)
DBA/2J ENSMUSG00185039008
 protein coding gene Chr6:84786596-84795330 (+)
FVB/NJ ENSMUSG00205023227
 protein coding gene Chr6:83412241-83420981 (+)
JF1/MsJ ENSUMUG00000020561
 protein coding gene Chr6:83727916-83736613 (+)
LP/J ENSMUSG00230048097
 protein coding gene Chr6:85920795-85929529 (+)
NOD/ShiLtJ ENSMUSG00190040135
 protein coding gene Chr6:83857937-83866681 (+)
NZO/HlLtJ ENSMUSG00225016553
 protein coding gene Chr6:87887547-87896285 (+)
PWK/PhJ ENSLUMG00010033894
 protein coding gene Chr6:83143318-83152019 (+)
SPRET/EiJ ENSMSPG00010040922
 protein coding gene Chr6:85277446-85286206 (+)
WSB/EiJ ENSIUOG00005031378
 protein coding gene Chr6:84771391-84780098 (+)



Homology
more
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
  • Links
    NCBI Gene ID: 27302
    UniProt: O95393

  • Chr Location
    2p13.3; chr2:68860909-68871397 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Bmp10 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    13 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased embryo size, cardiac dysgenesis, defects in early embryonic vascular development, enlarged pericardium, arteriovenous malformations, and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Tissues
    61
  • cDNA Data
    4
  • Literature Summary
    107
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12154 NCBI Gene Model | MGI Sequence Detail 5519 C57BL/6J ±  kb
    transcript NM_009756 RefSeq | MGI Sequence Detail 1325 C57BL/6  
    polypeptide Q9R229 UniProt | EBI | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 4
      Primer pair 10
      Other 7
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:5616115
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 107
      Diseases 1
      Gene Ontology 16
      Phenotypes 32
    • Earliest
      J:53506 Neuhaus H, et al., Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999 Feb;80(2):181-4
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory