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Bmp10
Gene Detail
Symbol

Name
ID
Bmp10
bone morphogenetic protein 10
MGI:1338820
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.96 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:87429002-87434512 bp, + strand
From NCBI annotation of GRCm38

  5511 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BMP10
Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp10

Human
homologs
BMP10, bone morphogenetic protein 10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 27302
neXtProt AC: NX_O95393

Human Chr (Location): 2p13.3; chr2:68865481-68871517 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Genomic Mutations involving Bmp10 (1)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice display embryonic lethality with cardiac dysgenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process activin receptor signaling pathway, adult heart development, ...
Component cell surface, cytoplasm, ...
Function cytokine activity, growth factor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (43)    Tissues (34)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 8
RT-PCR 11
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA BMP10 ZFIN bmp10    NEW 
Molecular
reagents
All nucleic(8) cDNA(4) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030046 (Evidence)
Entrez Gene 12154 (Evidence)
UniGene 483321
DFCI TC1599068
DoTS DT.87035209
NIA Mouse Gene Index U007132
Consensus CDS Project CCDS51838.1
International Mouse Phenotyping Consortium Status Bmp10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12154 NCBI Gene Model | MGI Sequence Detail 5511 C57BL/6J ±  kb
transcript NM_009756 RefSeq | MGI Sequence Detail 1317 Not Specified 
polypeptide Q9R229 UniProt | EBI | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000163 BMP10
Graphical View of Protein Domain Structure
References
(Earliest) J:53506 Neuhaus H, et al., Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999 Feb;80(2):181-4
(Latest) J:220807 Shamis Y, et al., Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory