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Bmp10 Gene Detail
Summary
  • Symbol
    Bmp10
  • Name
    bone morphogenetic protein 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338820
    NCBI Gene: 12154
  • Gene Overview
    MyGene.info: BMP10
Location & Maps
more
  • Sequence Map
    Chr6:87428994-87437677 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8684 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 27302
    neXtProt AC: NX_O95393

  • Chr Location
    2p13.3; chr2:68865481-68871517 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    3 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Spontaneous
    1
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    1 involving Bmp10
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display decreased embryo size, cardiac dysgenesis, defects in early embryonic vascular development, enlarged pericardium, arteriovenous malformations, and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057176 VEGA Gene Model | MGI Sequence Detail 8684 C57BL/6J ±  kb
transcript OTTMUST00000140779 VEGA | MGI Sequence Detail 4490 Not Applicable  
polypeptide OTTMUSP00000073676 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    41 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR002405 Inhibin, alpha subunit
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
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  • All nucleic 8
    cDNA 4
    Primer pair 3
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 74
    Developmental Gene Expression 49
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:53506 Neuhaus H, et al., Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999 Feb;80(2):181-4
  • Latest
    J:220807 Shamis Y, et al., Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory