Bmp10
Gene Detail

Symbol Name ID

Bmp10 bone morphogenetic protein 10 MGI:1338820

Feature Type

protein coding gene

Genetic Map

Chromosome 6

37.96 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:87429002-87434512 bp, + strand From NCBI annotation of GRCm38   5511 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp10

Human homologs

Human Homolog		BMP10, bone morphogenetic protein 10
NCBI Gene ID		27302
neXtProt AC		NX_O95393
Human Chr (Location)		2p13.3; chr2:69092613-69098649 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mice display embryonic lethality with cardiac dysgenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	activin receptor signaling pathway, adult heart development, ...
Component	cell surface, cytoplasm, ...
Function	cytokine activity, growth factor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (37 records)
Data Summary: Results (43)    Tissues (34)    Images (16)
Theiler Stages: 12, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	24
Northern blot	8
RT-PCR	11

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(4) Primer pair(3) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000030046 (Evidence)
Entrez Gene	12154 (Evidence)
UniGene	483321
DFCI	TC1599068
DoTS	DT.87035209
NIA Mouse Gene Index	U007132
Consensus CDS Project	CCDS51838.1
International Mouse Knockout Project Status	Bmp10

Sequences

Length	Strain/Species
genomic	12154	NCBI Gene Model | MGI Sequence Detail	5511	C57BL/6J
transcript	NM_009756	RefSeq | MGI Sequence Detail	1317	Not Specified
polypeptide	Q9R229	UniProt | EBI | MGI Sequence Detail	421	Not Applicable

All sequences(14) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002405	Inhibin, alpha subunit
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000163	BMP10

Graphical View of Protein Domain Structure

References

(Earliest) J:53506 Neuhaus H, et al., Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999 Feb;80(2):181-4
(Latest) J:190992 Harmelink C, et al., Myocardial Mycn is essential for mouse ventricular wall morphogenesis. Dev Biol. 2013 Jan 1;373(1):53-63
All references(61)