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Bmp10 Gene Detail
Summary
  • Symbol
    Bmp10
  • Name
    bone morphogenetic protein 10
  • Synonyms
    b2b2711Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338820
    NCBI Gene: 12154
  • Gene Overview
    MyGene.info: BMP10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:87428994-87437677 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8684 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.96 cM, cytoband D2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 27302
    neXtProt AC: NX_O95393
    UniProt: O95393

  • Chr Location
    2p13.3; chr2:68865481-68871517 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Bmp10 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    13 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased embryo size, cardiac dysgenesis, defects in early embryonic vascular development, enlarged pericardium, arteriovenous malformations, and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057176 VEGA Gene Model | MGI Sequence Detail 8684 C57BL/6J ±  kb
transcript OTTMUST00000140779 VEGA | MGI Sequence Detail 4490 Not Applicable  
polypeptide OTTMUSP00000073676 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    41 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 4
    Primer pair 3
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:5616115
References
more
  • Summaries
    All 91
    Developmental Gene Expression 57
    Diseases 1
    Gene Ontology 11
    Phenotypes 13
  • Earliest
    J:53506 Neuhaus H, et al., Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999 Feb;80(2):181-4
  • Latest
    J:239317 Bourke LM, et al., Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Differentiation. 2017 Mar - Apr;94:8-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory