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Shcbp1
Gene Detail
Symbol

Name
ID
Shcbp1
Shc SH2-domain binding protein 1
MGI:1338802
Synonyms
mPAL
Feature Type
protein coding gene
Genetic Map
Chromosome 8
2.09 cM, cytoband A1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:4735980-4779534 bp, - strand
From NCBI annotation of GRCm38

  43555 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SHCBP1
Gene Tree: Shcbp1

Human
homologs
SHCBP1, SHC SH2-domain binding protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 79801
neXtProt AC: NX_Q8NEM2

Human Synonyms: PAL

Human Chr (Location): 16q11.2; chr16:46580554-46622810 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(4) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Shcbp1 interacts with 59 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (83)    Tissues (42)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
cDNA source data(60)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase shcbp1    NEW 
Molecular
reagents
All nucleic(61) cDNA(61)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022322 (Evidence)
Entrez Gene 20419 (Evidence)
UniGene 37801
DFCI TC1576543, TC1607520
DoTS DT.91279691, DT.526680, DT.97377438, DT.94247456
NIA Mouse Gene Index U029558
Consensus CDS Project CCDS22088.1
International Mouse Phenotyping Consortium Status Shcbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20419 NCBI Gene Model | MGI Sequence Detail 43555 C57BL/6J ±  kb
transcript NM_011369 RefSeq | MGI Sequence Detail 2244 Not Specified 
polypeptide Q9Z179 UniProt | EBI | MGI Sequence Detail 668 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(302 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006626 Parallel beta-helix repeat
InterPro IPR012334 Pectin lyase fold
InterPro IPR011050 Pectin lyase fold/virulence factor
Protein Ontology PR:000014837 SHC SH2 domain-binding protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:53892 Schmandt R, et al., Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene. 1999 Mar 11;18(10):1867-79
(Latest) J:212898 Buckley MW, et al., Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation. PLoS One. 2014;9(8):e105576
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory