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Shcbp1
Gene Detail
 Symbol
Name
ID
Shcbp1
Shc SH2-domain binding protein 1
MGI:1338802
Synonyms mPAL
Feature Type protein coding gene
Genetic Map
Chromosome 8
2.09 cM, cytoband A1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:4735980-4779534 bp, - strand
From NCBI annotation of GRCm38

  43555 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Shcbp1

Human
homologs
Human Homolog SHCBP1, SHC SH2-domain binding protein 1
NCBI Gene ID 79801
neXtProt AC  NX_Q8NEM2
Human Synonyms  PAL
Human Chr (Location)  16q11.2; chr16:46580554-46621399 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(2) Targeted(2) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process fibroblast growth factor receptor signaling pathway, regulation of neural precursor cell proliferation
Component cellular_component
Function protein binding, SH2 domain binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (83)    Tissues (42)    Images (30)
Theiler Stages: 19, 20, 22, 23, 24
Assay TypeResults
RNA in situ 83
cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(61) cDNA(61)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022322 (Evidence)
Entrez Gene20419 (Evidence)
UniGene37801
DFCITC1576543, TC1607520
DoTSDT.526680, DT.91279691, DT.94247456, DT.97377438
NIA Mouse Gene IndexU029558
Consensus CDS ProjectCCDS22088.1
International Mouse Knockout Project StatusShcbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20419 NCBI Gene Model | MGI Sequence Detail 43555 C57BL/6J ±  kb
transcript NM_011369 RefSeq | MGI Sequence Detail 2244 Not Specified 
polypeptide Q9Z179 UniProt | EBI | MGI Sequence Detail 668 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(302 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006626 Parallel beta-helix repeat
InterPro IPR012334 Pectin lyase fold
InterPro IPR011050 Pectin lyase fold/virulence factor
Protein Ontology PR:000014837 SHC SH2 domain-binding protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:53892 Schmandt R, et al., Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene. 1999 Mar 11;18(10):1867-79
(Latest) J:183920 Chen J, et al., The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory