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Shcbp1 Gene Detail
Summary
  • Symbol
    Shcbp1
  • Name
    Shc SH2-domain binding protein 1
  • Synonyms
    mPAL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338802
    NCBI Gene: 20419
  • Gene Overview
    MyGene.info: SHCBP1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:4735980-4779534 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 2.09 cM, cytoband A1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    302 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338802
protein coding gene Chr8:4735976-4779567 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033338
protein coding gene Chr8:1749913-1789508 (-)
A/J MGP_AJ_G0033319
protein coding gene Chr8:1654621-1712971 (-)
AKR/J MGP_AKRJ_G0033250
protein coding gene Chr8:1723307-1761551 (-)
BALB/cJ MGP_BALBcJ_G0033319
protein coding gene Chr8:1728020-1768935 (-)
C3H/HeJ MGP_C3HHeJ_G0033033
protein coding gene Chr8:1771237-1813027 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033831
protein coding gene Chr8:1790696-1835050 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030802
protein coding gene Chr8:1534431-1580488 (-)
CAST/EiJ MGP_CASTEiJ_G0032356
protein coding gene Chr8:1592830-1634535 (-)
CBA/J MGP_CBAJ_G0033006
protein coding gene Chr8:1854702-1899781 (-)
DBA/2J MGP_DBA2J_G0033160
protein coding gene Chr8:1617515-1660041 (-)
FVB/NJ MGP_FVBNJ_G0033107
protein coding gene Chr8:1670668-1711769 (-)
LP/J MGP_LPJ_G0033254
protein coding gene Chr8:1633716-1683174 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033142
protein coding gene Chr8:1836470-1882909 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033848
protein coding gene Chr8:1711154-1756330 (-)
PWK/PhJ MGP_PWKPhJ_G0032068
protein coding gene Chr8:1606147-1645570 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031911
protein coding gene Chr8:1606676-1648923 (-)
WSB/EiJ MGP_WSBEiJ_G0032471
protein coding gene Chr8:1687046-1728699 (-)



Homology
more
  • Human Ortholog
    SHCBP1, SHC binding and spindle associated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHCBP1, SHC binding and spindle associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAL
  • Links
    NCBI Gene ID: 79801
    neXtProt AC: NX_Q8NEM2
    UniProt: Q8NEM2

  • Chr Location
    16q11.2; chr16:46578591-46624933 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32123
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SHCBP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal viability, fertility and T cell development but show decreased susceptibility to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20419 NCBI Gene Model | MGI Sequence Detail 43555 C57BL/6J ±  kb
transcript NM_011369 RefSeq | MGI Sequence Detail 2187 C57BL/6  
polypeptide Q9Z179 UniProt | EBI | MGI Sequence Detail 668 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 63
    cDNA 63

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:53892 Schmandt R, et al., Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene. 1999 Mar 11;18(10):1867-79
  • Latest
    J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory