Shcbp1
Gene Detail

Symbol Name ID

Shcbp1 Shc SH2-domain binding protein 1 MGI:1338802

Synonyms

mPAL

Feature Type

protein coding gene

Genetic Map

Chromosome 8

2.09 cM, cytoband A1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:4735980-4779534 bp, - strand From NCBI annotation of GRCm38   43555 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32123  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Shcbp1

Human homologs

Human Homolog		SHCBP1, SHC SH2-domain binding protein 1
NCBI Gene ID		79801
neXtProt AC		NX_Q8NEM2
Human Synonyms		PAL
Human Chr (Location)		16q11.2; chr16:46614466-46655311 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(2) Transposon induced(1)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	fibroblast growth factor receptor signaling pathway, regulation of neural precursor cell proliferation
Component	cellular_component
Function	protein binding, SH2 domain binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (83)    Tissues (42)    Images (30)
Theiler Stages: 19, 20, 22, 23, 24

Assay Type	Results
RNA in situ	83

cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) cDNA(61)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022322 (Evidence)
Entrez Gene	20419 (Evidence)
UniGene	37801
DFCI	TC1576543, TC1607520
DoTS	DT.526680, DT.91279691, DT.94247456, DT.97377438
NIA Mouse Gene Index	U029558
Consensus CDS Project	CCDS22088.1
International Mouse Knockout Project Status	Shcbp1

Sequences

Length	Strain/Species
genomic	20419	NCBI Gene Model | MGI Sequence Detail	43555	C57BL/6J
transcript	NM_011369	RefSeq | MGI Sequence Detail	2244	Not Specified
polypeptide	Q9Z179	UniProt | EBI | MGI Sequence Detail	668	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(160 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006626	Parallel beta-helix repeat
InterPro	IPR012334	Pectin lyase fold
InterPro	IPR011050	Pectin lyase fold/virulence factor
Protein Ontology	PR:000014837	SHC SH2 domain-binding protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:53892 Schmandt R, et al., Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene. 1999 Mar 11;18(10):1867-79
(Latest) J:183920 Chen J, et al., The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
All references(31)