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Shcbp1 Gene Detail
Summary
  • Symbol
    Shcbp1
  • Name
    Shc SH2-domain binding protein 1
  • Synonyms
    mPAL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338802
    NCBI Gene: 20419
Location & Maps
more
Homology
more
  • Human Ortholog
    SHCBP1, SHC SH2-domain binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHCBP1, SHC SH2-domain binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAL
  • Links
    NCBI Gene ID: 79801
    neXtProt AC: NX_Q8NEM2

  • Chr Location
    16q11.2; chr16:46580554-46622810 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    4
  • Transposon induced
    1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit normal viability, fertility and T cell development but show decreased susceptibility to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20419 NCBI Gene Model | MGI Sequence Detail 43555 C57BL/6J ±  kb
transcript NM_011369 RefSeq | MGI Sequence Detail 2244 Not Specified  
polypeptide Q9Z179 UniProt | EBI | MGI Sequence Detail 668 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    302 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014837 SHC SH2 domain-binding protein 1
  • InterPro Domains
    IPR006626 Parallel beta-helix repeat
    IPR012334 Pectin lyase fold
    IPR011050 Pectin lyase fold/virulence factor
Molecular
Reagents
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  • All nucleic 61
    cDNA 61

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:53892 Schmandt R, et al., Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene. 1999 Mar 11;18(10):1867-79
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory