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Cyfip1
Gene Detail
 Symbol
Name
ID
Cyfip1
cytoplasmic FMR1 interacting protein 1
MGI:1338801
Synonyms E030028J09Rik, l(7)1Rl, l7Rl1, P140SRA-1, pl-1, Shyc, Sra-1
Feature Type protein coding gene
Genetic Map
Chromosome 7
33.42 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:55841745-55930700 bp, + strand
From VEGA annotation of GRCm38

  88956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytoplasmic FMR1-interacting protein
Gene Tree: Cyfip1

Human
homologs
Human Homolog CYFIP1, cytoplasmic FMR1 interacting protein 1
NCBI Gene ID 23191
neXtProt AC  NX_Q7L576
Human Synonyms  P140SRA-1, SHYC, SRA1, SRA-1
Human Chr (Location)  15q11; chr15:22869465-22980419 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Chemically induced (ENU)(2) Gene trapped(37) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations at this locus result in embryonic lethality before the turning stage in homozygotes.
 
Interactions
Cyfip1 interacts with 160 markers (Mir7-1, Mir15a, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process axon extension, cell differentiation, ...
Component cell junction, cell projection, ...
Function actin binding, profilin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (57)    Tissues (36)    Images (6)
Theiler Stages: 11, 13, 17, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 57
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037588 (Evidence)
Ensembl Gene ModelENSMUSG00000030447 (Evidence)
Entrez Gene20430 (Evidence)
Consensus CDS ProjectCCDS21315.1, CCDS52262.1
International Mouse Knockout Project StatusCyfip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037588 VEGA Gene Model | MGI Sequence Detail 88956 C57BL/6J ±  kb
transcript OTTMUST00000096925 VEGA | MGI Sequence Detail 4538 Not Applicable 
polypeptide OTTMUSP00000054230 VEGA | MGI Sequence Detail 1253 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(11) UniProt(4)
Polymorphisms SNPs within 2kb(1193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008081 Cytoplasmic FMR1-interacting
InterPro IPR016536 Cytoplasmic FMR1-interacting, subgroup
InterPro IPR009828 Protein of unknown function DUF1394
Protein Ontology PR:000006090 cytoplasmic FMR1-interacting protein 1
References (Earliest) J:29903 Russell LB, et al., Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Genetics. 1995 Dec;141(4):1547-62
(Latest) J:180006 Yokoyama K, et al., NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J. 2011 Nov 30;30(23):4739-54
All references(47)
Other
accession IDs
MGI:1352763, MGI:2442012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory