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Fhl2
Gene Detail
Symbol

Name
ID
Fhl2
four and a half LIM domains 2
MGI:1338762
Synonyms
SLIM3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
22.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:43123074-43196984 bp, - strand
From VEGA annotation of GRCm38

  73911 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FHL2
Gene Tree: Fhl2

Human
homologs
FHL2, four and a half LIM domains 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2274
neXtProt AC: NX_Q14192

Human Synonyms: AAG11, DRAL, FHL-2, SLIM3, SLIM-3

Human Chr (Location): 2q12.2; chr2:105360815-105438773 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation display osteopenia and osteoporosis; cardiovascular development is normal but cardiac hypertrophy develops in mutants in response to beta-adrenergic stimulation.
 
Interactions
Fhl2 interacts with 102 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (165)    Tissues (125)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 132
In situ reporter (knock in) 10
Northern blot 12
RT-PCR 11
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FHL2 ; Xenbase fhl2 ; ZFIN fhl2a, fhl2b    NEW 
Molecular
reagents
All nucleic(67) cDNA(64) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000046311 (Evidence)
Ensembl Gene Model ENSMUSG00000008136 (Evidence)
Entrez Gene 14200 (Evidence)
UniGene 6799
DFCI TC1578047, TC1585853
DoTS DT.101389359, DT.494888, DT.97408097, DT.99854643
NIA Mouse Gene Index U021280
Consensus CDS Project CCDS14922.1
International Mouse Phenotyping Consortium Status Fhl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046311 VEGA Gene Model | MGI Sequence Detail 73911 C57BL/6J ±  kb
transcript OTTMUST00000120717 VEGA | MGI Sequence Detail 1563 Not Applicable 
polypeptide OTTMUSP00000066753 VEGA | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(581 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000007514 four and a half LIM domains protein 2
References
(Earliest) J:53041 Morgan MJ, et al., The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Biochem Biophys Res Commun. 1999 Feb 16;255(2):245-50
(Latest) J:219692 Hou Y, et al., FHL2 regulates hematopoietic stem cell functions under stress conditions. Leukemia. 2015 Mar;29(3):615-24
All references(75)
Other
accession IDs
MGI:2138652

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory