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Fhl2
Gene Detail
 Symbol
Name
ID
Fhl2
four and a half LIM domains 2
MGI:1338762
Synonyms SLIM3
Feature Type protein coding gene
Genetic Map
Chromosome 1
22.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:43123074-43163961 bp, - strand
From NCBI annotation of GRCm38

  40888 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fhl2

Human
homologs
Human Homolog FHL2, four and a half LIM domains 2
NCBI Gene ID 2274
neXtProt AC  NX_Q14192
Human Synonyms  AAG11, DRAL, FHL-2, SLIM3, SLIM-3
Human Chr (Location)  2q12.2; chr2:105360812-105438773 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation display osteopenia and osteoporosis; cardiovascular development is normal but cardiac hypertrophy develops in mutants in response to beta-adrenergic stimulation.
 
Interactions
Fhl2 interacts with 102 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process negative regulation of apoptotic process, negative regulation of transcription, DNA-templated, ...
Component actin cytoskeleton, cytoplasm, ...
Function identical protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (141)    Tissues (117)    Images (15)
Theiler Stages: 15, 17, 19, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 122
In situ reporter (knock in) 5
Northern blot 12
RT-PCR 2
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) cDNA(64) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000008136 (Evidence)
Entrez Gene14200 (Evidence)
UniGene6799
DFCITC1578047, TC1585853
DoTSDT.101389359, DT.494888, DT.97408097, DT.99854643
NIA Mouse Gene IndexU021280
Consensus CDS ProjectCCDS14922.1
International Mouse Knockout Project StatusFhl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14200 NCBI Gene Model | MGI Sequence Detail 40888 C57BL/6J ±  kb
transcript NM_010212 RefSeq | MGI Sequence Detail 1566 C57BL/6 
polypeptide O70433 UniProt | EBI | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(363 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000007514 four and a half LIM domains protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:53041 Morgan MJ, et al., The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Biochem Biophys Res Commun. 1999 Feb 16;255(2):245-50
(Latest) J:204718 Dahan J, et al., LIM-only protein FHL2 activates NF-kappaB signaling in the control of liver regeneration and hepatocarcinogenesis. Mol Cell Biol. 2013 Aug;33(16):3299-308
All references(72)
Other
accession IDs
MGI:2138652

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory