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Fhl2 Gene Detail
Summary
  • Symbol
    Fhl2
  • Name
    four and a half LIM domains 2
  • Synonyms
    SLIM3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338762
    NCBI Gene: 14200
  • Gene Overview
    MyGene.info: FHL2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43123074-43196984 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 22.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    580 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338762
protein coding gene Chr1:43123071-43198299 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015979
protein coding gene Chr1:42093087-42136638 (-)
A/J MGP_AJ_G0015963
protein coding gene Chr1:40829618-40870159 (-)
AKR/J MGP_AKRJ_G0015918
protein coding gene Chr1:41363587-41404121 (-)
BALB/cJ MGP_BALBcJ_G0015917
protein coding gene Chr1:40505628-40546496 (-)
C3H/HeJ MGP_C3HHeJ_G0015750
protein coding gene Chr1:41746328-41786985 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016370
protein coding gene Chr1:43826136-43868548 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014092
protein coding gene Chr1:37661926-37691737 (-)
CAST/EiJ MGP_CASTEiJ_G0015331
protein coding gene Chr1:41733456-41811311 (-)
CBA/J MGP_CBAJ_G0015722
protein coding gene Chr1:45108390-45151681 (-)
DBA/2J MGP_DBA2J_G0015823
protein coding gene Chr1:40106553-40148244 (-)
FVB/NJ MGP_FVBNJ_G0015825
protein coding gene Chr1:39634180-39674860 (-)
LP/J MGP_LPJ_G0015893
protein coding gene Chr1:42437851-42478906 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015845
protein coding gene Chr1:47097636-47139308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016417
protein coding gene Chr1:41577468-41621595 (-)
PWK/PhJ MGP_PWKPhJ_G0015114
protein coding gene Chr1:39990461-40032146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014896
protein coding gene Chr1:41571709-41662406 (-)
WSB/EiJ MGP_WSBEiJ_G0015393
protein coding gene Chr1:41617247-41662043 (-)



Homology
more
  • Human Ortholog
    FHL2, four and a half LIM domains 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FHL2, four and a half LIM domains 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAG11, DRAL, FHL-2, SLIM3, SLIM-3
  • Links
    NCBI Gene ID: 2274
    neXtProt AC: NX_Q14192
    UniProt: Q14192

  • Chr Location
    2q12.2; chr2:105360826-105438773 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20372
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FHL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation display osteopenia and osteoporosis; cardiovascular development is normal but cardiac hypertrophy develops in mutants in response to beta-adrenergic stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008136 Ensembl Gene Model | MGI Sequence Detail 73911 C57BL/6J ±  kb
    transcript ENSMUST00000008280 Ensembl | MGI Sequence Detail 1563 Not Applicable  
    polypeptide ENSMUSP00000008280 Ensembl | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 64
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138652
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 18
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:53041 Morgan MJ, et al., The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Biochem Biophys Res Commun. 1999 Feb 16;255(2):245-50
    • Latest
      J:261110 Masemann D, et al., The Four-and-a-Half LIM Domain Protein 2 Supports Influenza A Virus-Induced Lung Inflammation by Restricting the Host Adaptive Immune Response. Am J Pathol. 2018 May;188(5):1236-1245

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory