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Colq Gene Detail
Summary
  • Symbol
    Colq
  • Name
    collagen like tail subunit of asymmetric acetylcholinesterase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338761
    NCBI Gene: 382864
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31245039-31299820 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.18 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1568 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338761
 protein coding gene Chr14:31245039-31313300 (-)
129S1/SvImJ ENSMUSG00200036425
 protein coding gene Chr14:23069156-23136758 (-)
A/J ENSMUSG00195012022
 protein coding gene Chr14:24142313-24210577 (-)
AKR/J ENSMUSG00220029554
 protein coding gene Chr14:23254674-23322946 (-)
BALB/cJ ENSMUSG00180026329
 protein coding gene Chr14:23230874-23299154 (-)
C3H/HeJ ENSMUSG00175035752
 protein coding gene Chr14:23298156-23366417 (-)
C57BL/6NJ ENSMUSG00215020801
 protein coding gene Chr14:23536587-23604851 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019078
 protein coding gene Chr14:23850788-23917925 (-)
CAST/EiJ ENSTCUG00005021140
 protein coding gene Chr14:23391170-23459281 (-)
CBA/J ENSMUSG00210041739
 protein coding gene Chr14:23541053-23609316 (-)
DBA/2J ENSMUSG00185037794
 protein coding gene Chr14:27810355-27878608 (-)
FVB/NJ ENSMUSG00205026633
 protein coding gene Chr14:23400193-23468459 (-)
JF1/MsJ ENSUMUG00000021223
 protein coding gene Chr14:35070426-35142134 (-)
LP/J ENSMUSG00230034304
 protein coding gene Chr14:35093162-35160757 (-)
NOD/ShiLtJ ENSMUSG00190018511
 protein coding gene Chr14:23554689-23622932 (-)
NZO/HlLtJ ENSMUSG00225035802
 protein coding gene Chr14:29429360-29497622 (-)
PWK/PhJ ENSLUMG00010022103
 protein coding gene Chr14:11667510-11740638 (-)
SPRET/EiJ ENSMSPG00010034705
 protein coding gene Chr14:25216462-25279223 (-)
WSB/EiJ ENSIUOG00005012365
 protein coding gene Chr14:23360185-23428631 (-)



Homology
more
  • Human Ortholog
    COLQ, collagen like tail subunit of asymmetric acetylcholinesterase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COLQ, collagen like tail subunit of asymmetric acetylcholinesterase
  • Synonyms
    CMS5, EAD
  • Links
    NCBI Gene ID: 8292
    UniProt: Q9Y215

  • Chr Location
    3p25.1; chr3:15450132-15521928 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Colq mouse models; 1 with human COLQ associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit tremors, reduced body weight, lack of asymmetric forms of acetylcholinesterase and butyrylcholinesterase, and lethality prior to maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382864 NCBI Gene Model | MGI Sequence Detail 54782 C57BL/6J ±  kb
    transcript NM_009937 RefSeq | MGI Sequence Detail 2777 C57BL/6  
    polypeptide O35348 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:54000 Krejci E, et al., The mammalian gene of acetylcholinesterase-associated collagen. J Biol Chem. 1997 Sep 5;272(36):22840-7
    • Latest
      J:378014 Petrov K, et al., An alpha7 nicotinic and GABA(B) receptor-mediated pathway controls acetylcholine release in the tripartite neuromuscular junction. J Physiol. 2025 Jan;603(2):507-527
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory