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Ikbkg Gene Detail
Summary
  • Symbol
    Ikbkg
  • Name
    inhibitor of kappaB kinase gamma
  • Synonyms
    1110037D23Rik, IKK[g], NEMO
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338074
    NCBI Gene: 16151
  • Gene Overview
    MyGene.info: IKBKG
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74393290-74453854 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 38.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338074
protein coding gene ChrX:74393290-74456792 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035847
protein coding gene ChrX:70201509-70262158 (+)
A/J MGP_AJ_G0035828
protein coding gene ChrX:70381258-70444769 (+)
AKR/J MGP_AKRJ_G0035753
protein coding gene ChrX:72279655-72345455 (+)
BALB/cJ MGP_BALBcJ_G0035813
protein coding gene ChrX:69406513-69465759 (+)
C3H/HeJ MGP_C3HHeJ_G0035518
protein coding gene ChrX:70672992-70733260 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036343
protein coding gene ChrX:72366518-72447983 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033187
protein coding gene ChrX:69444220-69510507 (+)
CAST/EiJ MGP_CASTEiJ_G0034809
protein coding gene ChrX:56050205-56112562 (+)
CBA/J MGP_CBAJ_G0035493
protein coding gene ChrX:74365662-74431394 (+)
DBA/2J MGP_DBA2J_G0035650
protein coding gene ChrX:69844170-69903114 (+)
FVB/NJ MGP_FVBNJ_G0035594
protein coding gene ChrX:69184896-69246687 (+)
LP/J MGP_LPJ_G0035735
protein coding gene ChrX:70971508-71033656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035632
protein coding gene ChrX:76917937-76978905 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036365
protein coding gene ChrX:70014946-70077209 (+)
PWK/PhJ MGP_PWKPhJ_G0034508
protein coding gene ChrX:54013228-54071430 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034342
protein coding gene ChrX:56922752-56986698 (+)
WSB/EiJ MGP_WSBEiJ_G0034950
protein coding gene ChrX:69299569-69359696 (+)



Homology
more
  • Human Ortholog
    IKBKG, inhibitor of nuclear factor kappa B kinase subunit gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IKBKG, inhibitor of nuclear factor kappa B kinase subunit gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMCBX1, EDAID1, FIP3, FIP-3, Fip3p, IKKAP1, IKKG, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
  • Links
    NCBI Gene ID: 8517
    neXtProt AC: NX_Q9Y6K9
    UniProt: Q9Y6K9

  • Chr Location
    Xq28; chrX:154542240-154565046 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Ikbkg mouse models; 2 with human IKBKG associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    94 phenotypes from 8 alleles in 13 genetic backgrounds
    33 phenotypes from multigenic genotypes
    6 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males hemizygous for targeted null mutations exhibit embryonic lethality by embryonic day 13.5 from apoptotic liver damage. Heterozygous females show patchy skin lesions with granulocyte infiltration, growth retardation, and shortened lifespan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004221 Ensembl Gene Model | MGI Sequence Detail 60565 C57BL/6J ±  kb
    transcript ENSMUST00000004330 Ensembl | MGI Sequence Detail 6918 Not Applicable  
    polypeptide ENSMUSP00000004330 Ensembl | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 109
      Primer pair 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1923574, MGI:2147920, MGI:2147925, MGI:2148001
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 5
      Diseases 3
      Gene Ontology 25
      Phenotypes 51
    • Earliest
      J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
    • Latest
      J:257471 Kanaya T, et al., Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-kappaB signaling. J Exp Med. 2018 Feb 5;215(2):501-519

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory