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Ikbkg
Gene Detail
 Symbol
Name
ID
Ikbkg
inhibitor of kappaB kinase gamma
MGI:1338074
Synonyms 1110037D23Rik, IKK[g], NEMO
Feature Type protein coding gene
Genetic Map
Chromosome X
38.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:74393290-74453854 bp, + strand
From VEGA annotation of GRCm38

  60565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase complex, regulatory subunit NEMO
Gene Tree: Ikbkg

Human
homologs
Human Homolog IKBKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
NCBI Gene ID 8517
neXtProt AC  NX_Q9Y6K9
Human Synonyms  AMCBX1, FIP3, FIP-3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
Human Chr (Location)  Xq28; chrX:154541165-154568573 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human IKBKG
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(7) Targeted(9)
 
Males hemizygous for targeted null mutations exhibit embryonic lethality by embryonic day 13.5 from apoptotic liver damage. Heterozygous females show patchy skin lesions with granulocyte infiltration, growth retardation, and shortened lifespan.
 
Human Diseases Modeled Using Mouse Ikbkg (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Ikbkg interacts with 455 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process activation of NF-kappaB-inducing kinase activity, B cell homeostasis, ...
Component cytoplasm, cytosol, ...
Function K63-linked polyubiquitin binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (32)    Tissues (23)    Images (2)
Theiler Stages: 2, 3, 4, 5, 23, 28
Assay TypeResults
RNA in situ 24
RT-PCR 8
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) cDNA(108) Primer pair(1)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000017732 (Evidence)
Ensembl Gene ModelENSMUSG00000004221 (Evidence)
Entrez Gene16151 (Evidence)
UniGene12967
DFCITC1582363, TC1636378, TC1661809, TC1664745, TC1668404, TC1751524
DoTSDT.101386027, DT.103585988, DT.103586026, DT.111032035, DT.492275, DT.91370515, DT.97340005, DT.97382393, DT.97384415
NIA Mouse Gene IndexU019961
PDB2V4H, 2ZVN, 2ZVO, 3JSV, 4OWF, 3F89
Consensus CDS ProjectCCDS30233.1, CCDS41023.1, CCDS53108.1, CCDS53109.1
International Mouse Knockout Project StatusIkbkg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017732 VEGA Gene Model | MGI Sequence Detail 60565 C57BL/6J ±  kb
transcript OTTMUST00000047322 VEGA | MGI Sequence Detail 1867 Not Applicable 
polypeptide OTTMUSP00000021358 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(28) UniProt(12)
Polymorphisms SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021063 NF-kappa-B essential modulator NEMO, N-terminal
Protein Ontology PR:000001752 NF-kappa-B essential modulator
References (Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:208264 Tarantino N, et al., TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures. J Cell Biol. 2014 Jan 20;204(2):231-45
All references(111)
Disease annotation references (2)
Other
accession IDs
MGI:1923574, MGI:2147920, MGI:2147925, MGI:2148001

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory