Ikbkg
Gene Detail

Symbol Name ID

Ikbkg inhibitor of kappaB kinase gamma MGI:1338074

Synonyms

1110037D23Rik, IKK[g], NEMO

Feature Type

protein coding gene

Genetic Map

Chromosome X

38.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:74393290-74453854 bp, + strand From VEGA annotation of GRCm38   60565 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 zebrafish

Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase complex, regulatory subunit NEMO
Gene Tree: Ikbkg

Human homologs

Human Homolog		IKBKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
NCBI Gene ID		8517
neXtProt AC		NX_Q9Y6K9
Human Synonyms		AMCBX1, FIP3, FIP-3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
Human Chr (Location)		Xq28; chrX:153770459-153793261 (+)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human IKBKG

Alleles and phenotypes

All alleles(16) : Targeted(8) Gene trapped(7) Chemically induced(1)
 

Males hemizygous for targeted null mutations exhibit embryonic lethality by embryonic day 13.5 from apoptotic liver damage. Heterozygous females show patchy skin lesions with granulocyte infiltration, growth retardation, and shortened lifespan.

 
Human Diseases Modeled Using Mouse Ikbkg (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	activation of NF-kappaB-inducing kinase activity, B cell homeostasis, ...
Component	cytoplasm, cytoplasmic part, ...
Function	kinase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (39)    Tissues (28)    Images (2)
Theiler Stages: 2, 3, 4, 5, 23, 28

Assay Type	Results
RNA in situ	24
RT-PCR	15

cDNA source data(111)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(113) cDNA(112) Primer pair(1)
Microarray probesets(11)

Other database links

VEGA Gene Model	OTTMUSG00000017732 (Evidence)
Ensembl Gene Model	ENSMUSG00000004221 (Evidence)
Entrez Gene	16151 (Evidence)
UniGene	12967
DFCI	TC1582363, TC1636378, TC1661809, TC1664745, TC1668404, TC1751524
DoTS	DT.101386027, DT.103585988, DT.103586026, DT.111032035, DT.492275, DT.91370515, DT.97340005, DT.97382393, DT.97384415
NIA Mouse Gene Index	U019961
PDB	2V4H, 2ZVN, 2ZVO, 3JSV, 3F89
Consensus CDS Project	CCDS30233.1, CCDS41023.1, CCDS53108.1, CCDS53109.1
International Mouse Knockout Project Status	Ikbkg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017732	VEGA Gene Model | MGI Sequence Detail	60565	C57BL/6J
transcript	OTTMUST00000042945	VEGA | MGI Sequence Detail	6994	Not Applicable
polypeptide	OTTMUSP00000019310	VEGA | MGI Sequence Detail	412	Not Applicable

All sequences(132) RefSeq(14) UniProt(12)

Polymorphisms

SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021063	NF-kappa-B essential modulator NEMO, N-terminal
Protein Ontology	PR:000001752	NF-kappa-B essential modulator

References

(Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:192990 Kensche T, et al., Analysis of nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-kappaB. J Biol Chem. 2012 Jul 6;287(28):23626-34
All references(101)

Other accession IDs

MGI:1923574, MGI:2147920, MGI:2147925, MGI:2148001