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Ikbkg
Gene Detail
Symbol

Name
ID
Ikbkg
inhibitor of kappaB kinase gamma
MGI:1338074
Synonyms
1110037D23Rik, IKK[g], NEMO
Feature Type
protein coding gene
Genetic Map
Chromosome X
38.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:74393290-74453854 bp, + strand
From VEGA annotation of GRCm38

  60565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IKBKG
Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase complex, regulatory subunit NEMO
Gene Tree: Ikbkg

Human
homologs
IKBKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8517
neXtProt AC: NX_Q9Y6K9

Human Synonyms: AMCBX1, FIP3, FIP-3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9

Human Chr (Location): Xq28; chrX:154541204-154568573 (+)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human IKBKG

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(7) Targeted(9)
 
Males hemizygous for targeted null mutations exhibit embryonic lethality by embryonic day 13.5 from apoptotic liver damage. Heterozygous females show patchy skin lesions with granulocyte infiltration, growth retardation, and shortened lifespan.
 
Human Diseases Modeled in Mice Using Ikbkg (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Ikbkg interacts with 454 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process activation of NF-kappaB-inducing kinase activity, B cell homeostasis, ...
Component cytoplasm, cytosol, ...
Function K63-linked polyubiquitin binding, linear polyubiquitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (32)    Tissues (23)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 8
cDNA source data(107)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ikbkg ; ZFIN ikbkg    NEW 
Molecular
reagents
All nucleic(109) cDNA(108) Primer pair(1)
Microarray probesets(11)
Other database
links
VEGA Gene Model OTTMUSG00000017732 (Evidence)
Ensembl Gene Model ENSMUSG00000004221 (Evidence)
Entrez Gene 16151 (Evidence)
UniGene 12967
DFCI TC1751524, TC1636378, TC1582363, TC1668404, TC1664745, TC1661809
DoTS DT.97384415, DT.103585988, DT.97382393, DT.101386027, DT.103586026, DT.97340005, DT.91370515, DT.111032035, DT.492275
NIA Mouse Gene Index U019961
PDB 2V4H, 2ZVO, 2ZVN, 4OWF, 3JSV, 3F89
Consensus CDS Project CCDS30233.1, CCDS41023.1, CCDS53108.1, CCDS53109.1
International Mouse Phenotyping Consortium Status Ikbkg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017732 VEGA Gene Model | MGI Sequence Detail 60565 C57BL/6J ±  kb
transcript OTTMUST00000047324 VEGA | MGI Sequence Detail 3332 Not Applicable 
polypeptide OTTMUSP00000021360 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(148) RefSeq(30) UniProt(12)
Polymorphisms
SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021063 NF-kappa-B essential modulator NEMO, N-terminal
Protein Ontology PR:000001752 NF-kappa-B essential modulator
References
(Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:220480 Boaru SG, et al., NLRP3 inflammasome expression is driven by NF-kappaB in cultured hepatocytes. Biochem Biophys Res Commun. 2015 Mar 13;458(3):700-6
All references(117)
Disease annotation references (4)
Other
accession IDs
MGI:1923574, MGI:2147920, MGI:2147925, MGI:2148001

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory