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Ikbkb Gene Detail
Summary
  • Symbol
    Ikbkb
  • Name
    inhibitor of kappaB kinase beta
  • Synonyms
    IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338071
    NCBI Gene: 16150
  • Gene Overview
    MyGene.info: IKBKB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:22659212-22706589 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47378 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM, cytoband A3-A4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IKBKB, inhibitor of nuclear factor kappa B kinase subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IKBKB, inhibitor of nuclear factor kappa B kinase subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IKK2, IKKB, IKK-beta, IMD15, NFKBIKB
  • Links
    NCBI Gene ID: 3551
    neXtProt AC: NX_O14920
    UniProt: O14920

  • Chr Location
    8p11.21; chr8:42271302-42332653 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 13 alleles in 16 genetic backgrounds
    79 phenotypes from multigenic genotypes
    3 images
    180 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit liver degeneration and die in midgestation. Conditional mutations that lack gene expression in lymphoid cells or epidermal keratinocytes exhibit B and T cell deficits and skin inflammation, respectively.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020581 VEGA Gene Model | MGI Sequence Detail 47378 C57BL/6J ±  kb
    transcript OTTMUST00000048766 VEGA | MGI Sequence Detail 3580 Not Applicable  
    polypeptide OTTMUSP00000022455 VEGA | MGI Sequence Detail 757 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      51 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 119

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2142466
    References
    more
    • Summaries
      All 341
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 25
      Phenotypes 180
    • Earliest
      J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
    • Latest
      J:257782 Armaka M, et al., The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts. Nat Commun. 2018 Feb 12;9(1):618

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory