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Ikbkb
Gene Detail
Symbol

Name
ID
Ikbkb
inhibitor of kappaB kinase beta
MGI:1338071
Synonyms
IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.42 cM, cytoband A3-A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:22659212-22706589 bp, - strand
From VEGA annotation of GRCm38

  47378 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7782  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase complex alpha-like subunit
Gene Tree: Ikbkb

Human
homologs
Human Homolog IKBKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI Gene ID 3551
neXtProt AC  NX_O14920
Human Synonyms  IKK2, IKKB, IKK-beta, IMD15, NFKBIKB
Human Chr (Location)  8p11.2; chr8:42271302-42332653 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IKBKB
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(2) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit liver degeneration and die in midgestation. Conditional mutations that lack gene expression in lymphoid cells or epidermal keratinocytes exhibit B and T cell deficits and skin inflammation, respectively.
 
Phenotype Images(3)
Interactions
Ikbkb interacts with 259 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process B cell homeostasis, cellular response to tumor necrosis factor, ...
Component CD40 receptor complex, cytoplasm, ...
Function ATP binding, IkappaB kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (28)    Tissues (19)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 4
cDNA source data(115)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(119) cDNA(119)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000020581 (Evidence)
Ensembl Gene ModelENSMUSG00000031537 (Evidence)
Entrez Gene16150 (Evidence)
UniGene277886
DFCITC1634947, TC1625530, TC1591753, TC1574554
DoTSDT.482112, DT.101373632, DT.101200942, DT.94186387, DT.55232479, DT.487759, DT.55174791, DT.94188736, DT.99860594
NIA Mouse Gene IndexU029639
EC2.7.11.10
Consensus CDS ProjectCCDS22182.1, CCDS52522.1
International Mouse Knockout Project StatusIkbkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020581 VEGA Gene Model | MGI Sequence Detail 47378 C57BL/6J ±  kb
transcript OTTMUST00000048766 VEGA | MGI Sequence Detail 3580 Not Applicable 
polypeptide OTTMUSP00000022455 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(122) RefSeq(14) UniProt(17)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022007 I-kappa-kinase-beta NEMO binding domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000001776 inhibitor of nuclear factor kappa-B kinase subunit beta
References
(Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:214148 Bonnegarde-Bernard A, et al., Routes of allergic sensitization and myeloid cell IKKbeta differentially regulate antibody responses and allergic airway inflammation in male and female mice. PLoS One. 2014;9(3):e92307
All references(217)
Other
accession IDs
MGI:2142466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory