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Ikbkb
Gene Detail
Symbol

Name
ID
Ikbkb
inhibitor of kappaB kinase beta
MGI:1338071
Synonyms
IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.42 cM, cytoband A3-A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:22659212-22706589 bp, - strand
From VEGA annotation of GRCm38

  47378 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7782  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IKBKB
Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase complex alpha-like subunit
Gene Tree: Ikbkb

Human
homologs
IKBKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3551
neXtProt AC: NX_O14920

Human Synonyms: IKK2, IKKB, IKK-beta, IMD15, NFKBIKB

Human Chr (Location): 8p11.2; chr8:42271302-42332653 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IKBKB

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(2) Targeted(12) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit liver degeneration and die in midgestation. Conditional mutations that lack gene expression in lymphoid cells or epidermal keratinocytes exhibit B and T cell deficits and skin inflammation, respectively.
 
Phenotype Images(3)
Interactions
Ikbkb interacts with 258 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process B cell homeostasis, cellular response to tumor necrosis factor, ...
Component CD40 receptor complex, cytoplasm, ...
Function ATP binding, IkappaB kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (28)    Tissues (19)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 4
cDNA source data(115)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ikbkb ; ZFIN ikbkb    NEW 
Molecular
reagents
All nucleic(119) cDNA(119)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000020581 (Evidence)
Ensembl Gene Model ENSMUSG00000031537 (Evidence)
Entrez Gene 16150 (Evidence)
UniGene 277886
DFCI TC1625530, TC1591753, TC1574554, TC1634947
DoTS DT.101373632, DT.101200942, DT.55232479, DT.55174791, DT.482112, DT.487759, DT.94188736, DT.94186387, DT.99860594
NIA Mouse Gene Index U029639
EC 2.7.11.10
Consensus CDS Project CCDS22182.1, CCDS52522.1
International Mouse Phenotyping Consortium Status Ikbkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020581 VEGA Gene Model | MGI Sequence Detail 47378 C57BL/6J ±  kb
transcript OTTMUST00000048766 VEGA | MGI Sequence Detail 3580 Not Applicable 
polypeptide OTTMUSP00000022455 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(15) UniProt(9)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022007 I-kappa-kinase-beta NEMO binding domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000001776 inhibitor of nuclear factor kappa-B kinase subunit beta
References
(Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:219454 Guo W, et al., IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response. Biochem Biophys Res Commun. 2014 May 16;447(4):563-8
All references(224)
Other
accession IDs
MGI:2142466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory