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Ikbkb Gene Detail
Summary
  • Symbol
    Ikbkb
  • Name
    inhibitor of kappaB kinase beta
  • Synonyms
    IKK2, IKK-2, IKK[b], IKKbeta, IKK-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338071
    NCBI Gene: 16150
  • Gene Overview
    MyGene.info: IKBKB
Location & Maps
more
  • Sequence Map
    Chr8:22659212-22706589 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47378 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM, cytoband A3-A4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IKBKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IKBKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IKK2, IKKB, IKK-beta, IMD15, NFKBIKB
  • Links
    NCBI Gene ID: 3551
    neXtProt AC: NX_O14920

  • Chr Location
    8p11.21; chr8:42271302-42332653 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IKBKB associations

Human Disease Mouse Models
       Immunodeficiency 15; IMD15   OMIM: 615592
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    69 phenotypes from 13 alleles in 16 genetic backgrounds
    79 phenotypes from multigenic genotypes
    3 images
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    1
  • Gene trapped
    2
  • Targeted
    12
  • Transgenic
    3
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit liver degeneration and die in midgestation. Conditional mutations that lack gene expression in lymphoid cells or epidermal keratinocytes exhibit B and T cell deficits and skin inflammation, respectively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020581 VEGA Gene Model | MGI Sequence Detail 47378 C57BL/6J ±  kb
transcript OTTMUST00000048766 VEGA | MGI Sequence Detail 3580 Not Applicable  
polypeptide OTTMUSP00000022455 VEGA | MGI Sequence Detail 757 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 119
    cDNA 119

    Microarray probesets 10
Other
Accession IDs
less
MGI:2142466
References
more
  • Summaries
    All 240
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 21
    Phenotypes 158
  • Earliest
    J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
  • Latest
    J:232206 Derudder E, et al., Canonical NF-kappaB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5065-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory