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Itsn1
Gene Detail
Symbol

Name
ID
Itsn1
intersectin 1 (SH3 domain protein 1A)
MGI:1338069
Synonyms
Eh domain, SH3 domain regulator of endocytosis 1, EHSH1, Ese1, Intersectin-L, Sh3p17
Feature Type
protein coding gene
Genetic Map
Chromosome 16
53.28 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:91729281-91920597 bp, + strand
From VEGA annotation of GRCm38

  191317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Itsn1

Human
homologs
Human Homolog ITSN1, intersectin 1 (SH3 domain protein)
NCBI Gene ID 6453
neXtProt AC  NX_Q15811
Human Synonyms  ITSN, SH3D1A, SH3P17
Human Chr (Location)  21q22.1-q22.2; chr21:33642400-33889305 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(47) Targeted(6)
Genomic Mutations involving Itsn1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous for a gene trapped allele exhibit embryonic lethal. Mice homozygous for a null allele exhibit some postnatal lethality and impaired vesicle recycling in surviving mice.
 
Interactions
Itsn1 interacts with 536 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process endocytosis, intracellular signal transduction, ...
Component cell junction, cell projection, ...
Function calcium ion binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (224)    Tissues (138)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 204
RT-PCR 20
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(24) Primer pair(2)
Microarray probesets(13)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021345 VEGA Gene Model | MGI Sequence Detail 191317 C57BL/6J ±  kb
transcript OTTMUST00000050614 VEGA | MGI Sequence Detail 7418 Not Applicable 
polypeptide OTTMUSP00000023658 VEGA | MGI Sequence Detail 1719 Not Applicable 

For the selected sequences
All sequences(235) RefSeq(26) UniProt(55)
Polymorphisms
SNPs within 2kb(940 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000261 EPS15 homology (EH)
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000009164 intersectin-1
References
(Earliest) J:53505 Sengar AS, et al., The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J. 1999 Mar 1;18(5):1159-71
(Latest) J:197322 Sakaba T, et al., Fast neurotransmitter release regulated by the endocytic scaffold intersectin. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8266-71
All references(56)
Other
accession IDs
MGI:2146349, MGI:2146354, MGI:2146410, MGI:2146490, MGI:2146499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory