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Itsn1
Gene Detail
 Symbol
Name
ID
Itsn1
intersectin 1 (SH3 domain protein 1A)
MGI:1338069
Synonyms Eh domain, SH3 domain regulator of endocytosis 1, EHSH1, Ese1, Intersectin-L, Sh3p17
Feature Type protein coding gene
Genetic Map
Chromosome 16
53.28 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:91729281-91920597 bp, + strand
From VEGA annotation of GRCm38

  191317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 zebrafish

Gene Tree: Itsn1

Human
homologs
Human Homolog ITSN1, intersectin 1 (SH3 domain protein)
NCBI Gene ID 6453
neXtProt AC  NX_Q15811
Human Synonyms  ITSN, SH3D1A, SH3P17
Human Chr (Location)  21q22.1-q22.2; chr21:33642400-33889305 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(47) Targeted(6)
Genomic Mutations involving Itsn1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous for a gene trapped allele exhibit embryonic lethal. Mice homozygous for a null allele exhibit some postnatal lethality and impaired vesicle recycling in surviving mice.
 
Interactions
Itsn1 interacts with 536 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process endocytosis, intracellular signal transduction, ...
Component cell junction, cell projection, ...
Function calcium ion binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (224)    Tissues (138)    Images (47)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 204
RT-PCR 20
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(24) Primer pair(2)
Microarray probesets(13)
Other database
links
VEGA Gene ModelOTTMUSG00000021345 (Evidence)
Ensembl Gene ModelENSMUSG00000022957 (Evidence)
Entrez Gene16443 (Evidence)
DFCITC1584703, TC1597170, TC1620882, TC1625075, TC1627657, TC1662024, TC1666992, TC1683493, TC1698002, TC1708909, TC1739285, TC1776214
DoTSDT.101402901, DT.101402902, DT.101402903, DT.103575472, DT.110713235, DT.110713240, DT.531795, DT.91447242, DT.94138695, DT.94147240, DT.99858357
NIA Mouse Gene IndexU017383, U064493
PDB3HS8, 3JV3
Consensus CDS ProjectCCDS37402.1, CCDS49913.1, CCDS49914.1
International Mouse Knockout Project StatusItsn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021345 VEGA Gene Model | MGI Sequence Detail 191317 C57BL/6J ±  kb
transcript OTTMUST00000050614 VEGA | MGI Sequence Detail 7418 Not Applicable 
polypeptide OTTMUSP00000023658 VEGA | MGI Sequence Detail 1719 Not Applicable 

For the selected sequences
All sequences(208) RefSeq(26) UniProt(28)
Polymorphisms SNPs within 2kb(940 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000261 EPS15 homology (EH)
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000009164 intersectin-1
References (Earliest) J:53505 Sengar AS, et al., The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J. 1999 Mar 1;18(5):1159-71
(Latest) J:197322 Sakaba T, et al., Fast neurotransmitter release regulated by the endocytic scaffold intersectin. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8266-71
All references(55)
Other
accession IDs
MGI:2146349, MGI:2146354, MGI:2146410, MGI:2146490, MGI:2146499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory