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Aebp2 Gene Detail
Summary
  • Symbol
    Aebp2
  • Name
    AE binding protein 2
  • Synonyms
    B230313N05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338038
    NCBI Gene: 11569
Location & Maps
more
  • Sequence Map
    Chr6:140622663-140678472 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55810 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 70.71 cM, cytoband G1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AEBP2, AE binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AEBP2, AE binding protein 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 121536
    neXtProt AC: NX_Q6ZN18

  • Chr Location
    12p12.3; chr12:19439492-19522239 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    2 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    46
  • Gene trapped
    45
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a mutation in this gene show complete embryonic lethality. Heterozygous mutant mice show aganglionic megacolon, hypopigmentation of the tail tip and hind toes, and a decreased startle reflex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034195 VEGA Gene Model | MGI Sequence Detail 55810 C57BL/6J ±  kb
transcript OTTMUST00000086726 VEGA | MGI Sequence Detail 2575 Not Applicable  
polypeptide OTTMUSP00000046976 VEGA | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    401 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000003798 zinc finger protein AEBP2
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2141575, MGI:2443066
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:55019 He GP, et al., Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression. J Biol Chem. 1999 May 21;274(21):14678-84
  • Latest
    J:177673 Kim H, et al., Aebp2 as an epigenetic regulator for neural crest cells. PLoS One. 2011;6(9):e25174

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory