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Mapk11 Gene Detail
Summary
  • Symbol
    Mapk11
  • Name
    mitogen-activated protein kinase 11
  • Synonyms
    P38b, p38beta, Prkm11, Sapk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338024
    NCBI Gene: 19094
  • Gene Overview
    MyGene.info: MAPK11
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89142482-89149606 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.66 cM, cytoband E3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338024
protein coding gene Chr15:89142482-89149628 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022220
protein coding gene Chr15:90317124-90324238 (-)
A/J MGP_AJ_G0022179
protein coding gene Chr15:86866032-86873151 (-)
AKR/J MGP_AKRJ_G0022154
protein coding gene Chr15:89432332-89439452 (-)
BALB/cJ MGP_BALBcJ_G0022185
protein coding gene Chr15:86965767-86974463 (-)
C3H/HeJ MGP_C3HHeJ_G0021955
protein coding gene Chr15:89420407-89427531 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022630
protein coding gene Chr15:93598563-93605618 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020155
protein coding gene Chr15:83088993-83096282 (-)
CAST/EiJ MGP_CASTEiJ_G0021477
protein coding gene Chr15:90204542-90211664 (-)
CBA/J MGP_CBAJ_G0021922
protein coding gene Chr15:96759511-96766879 (-)
DBA/2J MGP_DBA2J_G0022049
protein coding gene Chr15:86318669-86325785 (-)
FVB/NJ MGP_FVBNJ_G0022028
protein coding gene Chr15:85382829-85389942 (-)
LP/J MGP_LPJ_G0022120
protein coding gene Chr15:90475586-90482700 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022048
protein coding gene Chr15:101182788-101190168 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022645
protein coding gene Chr15:89467925-89474902 (-)
PWK/PhJ MGP_PWKPhJ_G0021218
protein coding gene Chr15:86362484-86369806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021052
protein coding gene Chr15:89201588-89208670 (-)
WSB/EiJ MGP_WSBEiJ_G0021526
protein coding gene Chr15:89956054-89963155 (-)



Homology
more
  • Human Ortholog
    MAPK11, mitogen-activated protein kinase 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAPK11, mitogen-activated protein kinase 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    p38-2, P38B, p38Beta, P38BETA2, PRKM11, SAPK2, SAPK2B
  • Links
    NCBI Gene ID: 5600
    neXtProt AC: NX_Q15759
    UniProt: Q15759

  • Chr Location
    22q13.33; chr22:50263713-50270393 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 7 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    3 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19094 NCBI Gene Model | MGI Sequence Detail 7125 C57BL/6J ±  kb
    transcript NM_011161 RefSeq | MGI Sequence Detail 2452 C57BL/6  
    polypeptide Q9WUI1 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 25
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 10
      Phenotypes 45
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:256992 Alam MS, et al., Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. PLoS Biol. 2018 Jan;16(1):e2004111

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory