About   Help   FAQ
Mapk11
Gene Detail
Symbol

Name
ID
Mapk11
mitogen-activated protein kinase 11
MGI:1338024
Synonyms
P38b, p38beta, Prkm11, Sapk2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.66 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:89142486-89149606 bp, - strand
From Ensembl annotation of GRCm38

  7121 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55684  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPK11
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk11

Human
homologs
MAPK11, mitogen-activated protein kinase 11
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5600
neXtProt AC: NX_Q15759

Human Synonyms: p38-2, P38B, p38Beta, P38BETA2, PRKM11, SAPK2, SAPK2B

Human Chr (Location): 22q13.33; chr22:50263713-50270393 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(1) Radiation induced(1) Targeted(15)
Genomic Mutations involving Mapk11 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit a normal phenotype.
 
Phenotype Images(5)
Interactions
Mapk11 interacts with 166 markers (Mir18, Mir18b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cellular response to virus, intracellular signal transduction, ...
Component cytoplasm, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (83)    Tissues (14)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapk11    NEW 
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000053137 (Evidence)
Entrez Gene 19094 (Evidence)
UniGene 91969
DFCI TC1580458, TC1727299
DoTS DT.40158588, DT.97382946
NIA Mouse Gene Index U036522
EC 2.7.11.24
Consensus CDS Project CCDS27741.1
International Mouse Phenotyping Consortium Status Mapk11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053137 Ensembl Gene Model | MGI Sequence Detail 7121 C57BL/6J ±  kb
transcript ENSMUST00000088823 Ensembl | MGI Sequence Detail 2440 Not Applicable 
polypeptide ENSMUSP00000086204 Ensembl | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008352 Mitogen-activated protein (MAP) kinase, p38
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010152 mitogen-activated protein kinase 11
References
(Earliest) J:113819 Jiang Y, et al., Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem. 1996 Jul 26;271(30):17920-6
(Latest) J:214296 Alam MS, et al., Counter-regulation of T cell effector function by differentially activated p38. J Exp Med. 2014 Jun 2;211(6):1257-70
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory