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Mapk11
Gene Detail
Symbol

Name
ID
Mapk11
mitogen-activated protein kinase 11
MGI:1338024
Synonyms
P38b, p38beta, Prkm11, Sapk2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.66 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:89142486-89149606 bp, - strand
From Ensembl annotation of GRCm38

  7121 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55684  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk11

Human
homologs
Human Homolog MAPK11, mitogen-activated protein kinase 11
NCBI Gene ID 5600
neXtProt AC  NX_Q15759
Human Synonyms  p38-2, P38B, p38Beta, P38BETA2, PRKM11, SAPK2, SAPK2B
Human Chr (Location)  22q13.33; chr22:50263713-50270350 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(1) Radiation induced(1) Targeted(14)
Genomic Mutations involving Mapk11 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit a normal phenotype.
 
Phenotype Images(3)
Interactions
Mapk11 interacts with 166 markers (Mir18, Mir18b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process intracellular signal transduction, MAPK cascade, ...
Component cytoplasm, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (83)    Tissues (14)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000053137 (Evidence)
Entrez Gene19094 (Evidence)
UniGene91969
DFCITC1727299, TC1580458
DoTSDT.97382946, DT.40158588
NIA Mouse Gene IndexU036522
EC2.7.11.24
Consensus CDS ProjectCCDS27741.1
International Mouse Knockout Project StatusMapk11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053137 Ensembl Gene Model | MGI Sequence Detail 7121 C57BL/6J ±  kb
transcript ENSMUST00000088823 Ensembl | MGI Sequence Detail 2440 Not Applicable 
polypeptide ENSMUSP00000086204 Ensembl | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008352 Mitogen-activated protein (MAP) kinase, p38
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010152 mitogen-activated protein kinase 11
References
(Earliest) J:113819 Jiang Y, et al., Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem. 1996 Jul 26;271(30):17920-6
(Latest) J:211851 Fransson L, et al., Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and beta-cells. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):126-36
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/23/2014
MGI 5.20
The Jackson Laboratory