Mapk11 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mapk11
mitogen-activated protein kinase 11
MGI:1338024

23 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Mapk11^tm1Jda/Mapk11^tm1Jda Mapk14^tm1Jda/Mapk14^tm1Jda involves: 129 * C57BL/6	abnormal T-helper 1 cell differentiation	J:165966
	abnormal T-helper 2 cell differentiation	J:165966
	abnormal T-helper 17 cell differentiation	J:165966
	decreased interferon-gamma secretion	J:165966
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:165966
	decreased susceptibility to induced arthritis	J:165966
	decreased T cell proliferation	J:165966
	decreased tumor necrosis factor secretion	J:165966
	increased interleukin-10 secretion	J:165966
Mapk11^tm1Jsca/Mapk11⁺ Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129P2/OlaHsd * C57BL/6 * CBA	primary sex reversal	J:191096
Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal fetal cardiomyocyte proliferation	J:176023
	abnormal liver morphology	J:176023
	abnormal neuron proliferation	J:176023
	exencephaly	J:176023
	increased hepatocyte apoptosis	J:176023
	lethality throughout fetal growth and development, complete penetrance	J:176023
	primary sex reversal	J:191096
	small liver	J:176023
	spina bifida	J:176023
	ventricular septal defect	J:176023
Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129P2/OlaHsd * C57BL/6 * CBA	normal nervous system phenotype	J:176023
	postnatal lethality, complete penetrance	J:176023
	ventricular septal defect	J:176023
Mapk11^tm1Jsca/Mapk11^tm1Jsca Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	arthritis	J:107771
	ileum inflammation	J:107771

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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