Mrvi1
Gene Detail

Symbol Name ID

Mrvi1 MRV integration site 1 MGI:1338023

Synonyms

Ris1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

57.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:110868266-110982461 bp, - strand From VEGA annotation of GRCm38   114196 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Mrvi1

Human homologs

Human Homolog		MRVI1, murine retrovirus integration site 1 homolog
NCBI Gene ID		10335
neXtProt AC		NX_Q9Y6F6
Human Synonyms		IRAG, JAW1L
Human Chr (Location)		11p15; chr11:10594638-10715535 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(5) Gene trapped(10)
 

Mice homozygous for a knock-out allele show lower blood pressure, a slightly reduced heart rate, and failure of cGMP-mediated relaxation of receptor-triggered smooth muscle contraction; 50% of mice die prematurely with an enlarged stomach, a dilated cecum, pyloric stenosis and impaired GI motility.

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Component

cytoplasm, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (51)    Tissues (6)    Images (22)
Theiler Stages: 23

Assay Type	Results
RNA in situ	51

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(2) cDNA(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033851 (Evidence)
Ensembl Gene Model	ENSMUSG00000005611 (Evidence)
Entrez Gene	17540 (Evidence)
DFCI	TC1597540, TC1613298, TC1650457, TC1691206
DoTS	DT.522542, DT.91337431, DT.97388532, DT.99544010
NIA Mouse Gene Index	U029124
Consensus CDS Project	CCDS21749.1, CCDS52362.1
International Mouse Knockout Project Status	Mrvi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033851	VEGA Gene Model | MGI Sequence Detail	114196	C57BL/6J
transcript	OTTMUST00000085305	VEGA | MGI Sequence Detail	5953	Not Applicable
polypeptide	OTTMUSP00000046075	VEGA | MGI Sequence Detail	921	Not Applicable

All sequences(60) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(779 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008677	MRVI1
Protein Ontology	PR:000010650	protein MRVI1

References

(Earliest) J:38298 Shaughnessy JD Jr, et al., cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G. Genomics. 1997 Jan 15;39(2):192-7
(Latest) J:175587 Maddox DM, et al., An ENU-induced mutation in the Mertk gene (Mertknmf12) leads to a slow form of retinal degeneration. Invest Ophthalmol Vis Sci. 2011 Jun;52(7):4703-9
All references(34)

Other accession IDs

MGI:2142290, MGI:892017