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Mrvi1 Gene Detail
Summary
  • Symbol
    Mrvi1
  • Name
    MRV integration site 1
  • Synonyms
    Ris1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338023
    NCBI Gene: 17540
  • Gene Overview
    MyGene.info: MRVI1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110868266-110982461 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.90 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1444 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338023
protein coding gene Chr7:110868257-110982909 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032862
protein coding gene Chr7:114375336-114490440 (-)
A/J MGP_AJ_G0032845
protein coding gene Chr7:111545441-111657612 (-)
AKR/J MGP_AKRJ_G0032777
protein coding gene Chr7:114331870-114455879 (-)
BALB/cJ MGP_BALBcJ_G0032850
protein coding gene Chr7:111225532-111341486 (-)
C3H/HeJ MGP_C3HHeJ_G0032560
protein coding gene Chr7:114344550-114457926 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033356
protein coding gene Chr7:119104952-119220809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030328
protein coding gene Chr7:113150965-113264762 (-)
CAST/EiJ MGP_CASTEiJ_G0031888
protein coding gene Chr7:105931036-106044805 (-)
CBA/J MGP_CBAJ_G0032533
protein coding gene Chr7:122994877-123111397 (-)
DBA/2J MGP_DBA2J_G0032685
protein coding gene Chr7:109627875-109748028 (-)
FVB/NJ MGP_FVBNJ_G0032638
protein coding gene Chr7:109484818-109597950 (-)
LP/J MGP_LPJ_G0032779
protein coding gene Chr7:115892543-116004289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032670
protein coding gene Chr7:124654944-124771163 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033376
protein coding gene Chr7:113352900-113470776 (-)
PWK/PhJ MGP_PWKPhJ_G0031595
protein coding gene Chr7:102470482-102582885 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031443
protein coding gene Chr7:100102058-100215906 (-)
WSB/EiJ MGP_WSBEiJ_G0032001
protein coding gene Chr7:114206807-114320628 (-)



Homology
more
  • Human Ortholog
    MRVI1, murine retrovirus integration site 1 homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRVI1, murine retrovirus integration site 1 homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRAG, JAW1L
  • Links
    NCBI Gene ID: 10335
    neXtProt AC: NX_Q9Y6F6
    UniProt: Q9Y6F6

  • Chr Location
    11p15.4; chr11:10573091-10693988 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4425
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MRVI1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show lower blood pressure, a slightly reduced heart rate, and failure of cGMP-mediated relaxation of receptor-triggered smooth muscle contraction; 50% of mice die prematurely with an enlarged stomach, a dilated cecum, pyloric stenosis and impaired GI motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005611 Ensembl Gene Model | MGI Sequence Detail 114196 C57BL/6J ±  kb
    transcript ENSMUST00000125758 Ensembl | MGI Sequence Detail 5953 Not Applicable  
    polypeptide ENSMUSP00000114578 Ensembl | MGI Sequence Detail 921 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR008677 MRVI1
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142290, MGI:892017
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 17
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory