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Sort1 Gene Detail
Summary
  • Symbol
    Sort1
  • Name
    sortilin 1
  • Synonyms
    2900053A11Rik, neurotensin receptor 3, Ntr3, Ntsr3, sortilin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338015
    NCBI Gene: 20661
  • Gene Overview
    MyGene.info: SORT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:108284082-108361511 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77430 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.90 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SORT1, sortilin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SORT1, sortilin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gp95, LDLCQ6, NT3, NTR3
  • Links
    NCBI Gene ID: 6272
    neXtProt AC: NX_Q99523
    UniProt: Q99523

  • Chr Location
    1p21.3-p13.1; chr1:109309565-109397945 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhbit increased protection from age- and injury-related neuron lose.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000007304 VEGA Gene Model | MGI Sequence Detail 77430 C57BL/6J ±  kb
    transcript OTTMUST00000132172 VEGA | MGI Sequence Detail 6836 Not Applicable  
    polypeptide OTTMUSP00000070509 VEGA | MGI Sequence Detail 858 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      336 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 172
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920246, MGI:2139828
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 16
      Phenotypes 33
    • Earliest
      J:45627 Morris NJ, et al., Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes. J Biol Chem. 1998 Feb 6;273(6):3582-7
    • Latest
      J:241643 Li J, et al., Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice. FEBS Lett. 2017 Apr;591(7):1018-1028

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory