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Sort1
Gene Detail
 Symbol
Name
ID
Sort1
sortilin 1
MGI:1338015
Synonyms 2900053A11Rik, neurotensin receptor 3, Ntr3, Ntsr3, sortilin
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.90 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:108284091-108361511 bp, + strand
From VEGA annotation of GRCm38

  77421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Sort1

Human
homologs
Human Homolog SORT1, sortilin 1
NCBI Gene ID 6272
neXtProt AC  NX_Q99523
Human Synonyms  Gp95, LDLCQ6, NT3
Human Chr (Location)  1p21.3-p13.1; chr1:109309565-109397941 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhbit increased protection from age- and injury-related neuron lose.
 
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cell differentiation, endocytosis, ...
Component cell surface, clathrin-coated vesicle, ...
Function enzyme binding, nerve growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (96)    Tissues (95)    Images (11)
Theiler Stages: 11, 13, 15, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 96
cDNA source data(172)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(173) cDNA(172) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000007304 (Evidence)
Ensembl Gene ModelENSMUSG00000068747 (Evidence)
Entrez Gene20661 (Evidence)
UniGene157119
DFCITC1603696, TC1612409, TC1653340
DoTSDT.101393175, DT.91375333, DT.99855618
NIA Mouse Gene IndexU042470
Consensus CDS ProjectCCDS17756.1
International Mouse Knockout Project StatusSort1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007304 VEGA Gene Model | MGI Sequence Detail 77421 C57BL/6J ±  kb
transcript OTTMUST00000016875 VEGA | MGI Sequence Detail 6796 Not Applicable 
polypeptide OTTMUSP00000007775 VEGA | MGI Sequence Detail 825 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(336 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006581 VPS10
Protein Ontology PR:000015412 sortilin
References (Earliest) J:53414 Hermans-Borgmeyer I, et al., Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. Brain Res Mol Brain Res. 1999 Mar 5;65(2):216-9
(Latest) J:210649 Gustafsen C, et al., The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion. Cell Metab. 2014 Feb 4;19(2):310-8
All references(68)
Other
accession IDs
MGI:1920246, MGI:2139828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory