About   Help   FAQ
Sort1
Gene Detail
Symbol

Name
ID
Sort1
sortilin 1
MGI:1338015
Synonyms
2900053A11Rik, neurotensin receptor 3, Ntr3, Ntsr3, sortilin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.90 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:108284091-108361511 bp, + strand
From VEGA annotation of GRCm38

  77421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SORT1
Gene Tree: Sort1

Human
homologs
SORT1, sortilin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6272
neXtProt AC: NX_Q99523

Human Synonyms: Gp95, LDLCQ6, NT3

Human Chr (Location): 1p21.3-p13.1; chr1:109309565-109397941 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhbit increased protection from age- and injury-related neuron lose.
 
Interactions
Sort1 interacts with 405 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cell differentiation, endocytosis, ...
Component cell surface, clathrin-coated vesicle, ...
Function enzyme binding, nerve growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (96)    Tissues (95)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
cDNA source data(172)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sort1 ; ZFIN sort1a, sort1b    NEW 
Molecular
reagents
All nucleic(173) cDNA(172) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000007304 (Evidence)
Ensembl Gene Model ENSMUSG00000068747 (Evidence)
Entrez Gene 20661 (Evidence)
UniGene 157119
DFCI TC1603696, TC1612409, TC1653340
DoTS DT.101393175, DT.91375333, DT.99855618
NIA Mouse Gene Index U042470
Consensus CDS Project CCDS17756.1
International Mouse Phenotyping Consortium Status Sort1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007304 VEGA Gene Model | MGI Sequence Detail 77421 C57BL/6J ±  kb
transcript OTTMUST00000016875 VEGA | MGI Sequence Detail 6796 Not Applicable 
polypeptide OTTMUSP00000007775 VEGA | MGI Sequence Detail 825 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(336 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006581 VPS10
Protein Ontology PR:000015412 sortilin
References
(Earliest) J:53414 Hermans-Borgmeyer I, et al., Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. Brain Res Mol Brain Res. 1999 Mar 5;65(2):216-9
(Latest) J:219379 Mortensen MB, et al., Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis. J Clin Invest. 2014 Dec;124(12):5317-22
All references(73)
Other
accession IDs
MGI:1920246, MGI:2139828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory