Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and neurotensin receptor activity, non-G protein-coupled. Involved in several processes, including glucose import; maintenance of synapse structure; and response to insulin. Acts upstream of or within endocytosis; negative regulation of fat cell differentiation; and protein targeting to lysosome. Located in cytoplasmic vesicle membrane; plasma membrane; and trans-Golgi network transport vesicle. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and retina. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human SORT1 (sortilin 1).