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Irs4
Gene Detail
Symbol

Name
ID
Irs4
insulin receptor substrate 4
MGI:1338009
Synonyms
IRS-4
Feature Type
protein coding gene
Genetic Map
Chromosome X
62.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:141710998-141725263 bp, - strand
From VEGA annotation of GRCm38

  14266 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137235  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque

HCOP human homology predictions: IRS4
Gene Tree: Irs4

Human
homologs
IRS4, insulin receptor substrate 4
Orthology source: HGNC

IDs:
NCBI Gene ID: 8471
neXtProt AC: NX_O14654

Human Synonyms: IRS-4, PY160

Human Chr (Location): Xq22.3; chrX:108719949-108736584 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit a 10% reduction in male adult size, slightly impaired oral glucose tolerance, and decreased reproductive ability.
 
Interactions
Irs4 interacts with 392 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process insulin receptor signaling pathway, regulation of lipid metabolic process, ...
Component cytosol, membrane, ...
Function insulin receptor binding, phosphatidylinositol 3-kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (168)    Tissues (95)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 88
Western blot 24
RT-PCR 56
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase irs4    NEW 
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(17) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019737 (Evidence)
Ensembl Gene Model ENSMUSG00000054667 (Evidence)
Entrez Gene 16370 (Evidence)
UniGene 261591
DFCI TC1597180
DoTS DT.91329222
NIA Mouse Gene Index U039743
Consensus CDS Project CCDS30445.1
International Mouse Phenotyping Consortium Status Irs4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019737 VEGA Gene Model | MGI Sequence Detail 14266 C57BL/6J ±  kb
transcript OTTMUST00000047234 VEGA | MGI Sequence Detail 6294 Not Applicable 
polypeptide OTTMUSP00000021317 VEGA | MGI Sequence Detail 1216 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000009109 insulin receptor substrate 4
References
(Earliest) J:53778 Fantin VR, et al., Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene. Endocrinology. 1999 Mar;140(3):1329-37
(Latest) J:184234 Chirivella L, et al., IRS2 signalling is required for the development of a subset of sensory spinal neurons. Eur J Neurosci. 2012 Feb;35(3):341-52
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory