Bcl10
Gene Detail

Symbol Name ID

Bcl10 B cell leukemia/lymphoma 10 MGI:1337994

Synonyms

BCL-10, cE10, mE10

Feature Type

protein coding gene

Genetic Map

Chromosome 3

71.03 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:145924378-145934283 bp, + strand From NCBI annotation of GRCm38   9906 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: B-cell lymphoma/leukemia 10
Gene Tree: Bcl10

Human homologs

Human Homolog		BCL10, B-cell CLL/lymphoma 10
NCBI Gene ID		8915
neXtProt AC		NX_O95999
Human Synonyms		CARMEN, c-E10, CIPER, CLAP, mE10
Human Chr (Location)		1p22; chr1:85731459-85742587 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human BCL10

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

About one-third of homozygous null embryos die exhibiting exencephaly. Surviving mutants display immunological defects including severe immunodeficiency, abnormal B cell development and function, and impaired humoral response to bacterial infection.

 

Gene Ontology (GO) classifications

All GO classifications: (76 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	cytoplasm, cytoplasmic microtubule, ...
Function	cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (51)    Tissues (40)    Images (15)
Theiler Stages: 10, 18, 19, 23, 25, 28

Assay Type	Results
RNA in situ	39
Northern blot	12

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000028191 (Evidence)
Entrez Gene	12042 (Evidence)
DFCI	TC1574160, TC1587322
DoTS	DT.494432, DT.91365290, DT.94206410
NIA Mouse Gene Index	U042489, U312844
Consensus CDS Project	CCDS17897.1
International Mouse Knockout Project Status	Bcl10

Sequences

Length	Strain/Species
genomic	12042	NCBI Gene Model | MGI Sequence Detail	9906	C57BL/6J
transcript	NM_009740	RefSeq | MGI Sequence Detail	1760	Not Specified
polypeptide	Q9Z0H7	UniProt | EBI | MGI Sequence Detail	233	Not Applicable

All sequences(44) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	DEATH-like
Protein Ontology	PR:000004689	B-cell lymphoma/leukemia 10

Graphical View of Protein Domain Structure

References

(Earliest) J:52071 Willis TG, et al., Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999 Jan 8;96(1):35-45
(Latest) J:190683 Yu M, et al., Critical role of B cell lymphoma 10 in BAFF-regulated NF-kappaB activation and survival of anergic B cells. J Immunol. 2012 Dec 1;189(11):5185-93
All references(72)

Other accession IDs

MGI:2139636, MGI:2140085