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Bcl10
Gene Detail
Symbol

Name
ID
Bcl10
B cell leukemia/lymphoma 10
MGI:1337994
Synonyms
BCL-10, cE10, mE10
Feature Type
protein coding gene
Genetic Map
Chromosome 3
71.03 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:145924378-145934283 bp, + strand
From NCBI annotation of GRCm38

  9906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: B-cell lymphoma/leukemia 10
Gene Tree: Bcl10

Human
homologs
Human Homolog BCL10, B-cell CLL/lymphoma 10
NCBI Gene ID 8915
neXtProt AC  NX_O95999
Human Synonyms  CARMEN, c-E10, CIPER, CLAP, mE10
Human Chr (Location)  1p22; chr1:85265776-85276921 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human BCL10
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix )
 
About one-third of homozygous null embryos die exhibiting exencephaly. Surviving mutants display immunological defects including severe immunodeficiency, abnormal B cell development and function, and impaired humoral response to bacterial infection.
 
Interactions
Bcl10 interacts with 110 markers (Mir7-1, Mir10a, Mir18b, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (51)    Tissues (40)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
Northern blot 12
cDNA source data(108)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) cDNA(108)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000028191 (Evidence)
Entrez Gene12042 (Evidence)
UniGene239141
DFCITC1574160, TC1587322
DoTSDT.494432, DT.91365290, DT.94206410
NIA Mouse Gene IndexU042489, U312844
Consensus CDS ProjectCCDS17897.1
International Mouse Knockout Project StatusBcl10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12042 NCBI Gene Model | MGI Sequence Detail 9906 C57BL/6J ±  kb
transcript NM_009740 RefSeq | MGI Sequence Detail 1959 C57BL/6 
polypeptide Q9Z0H7 UniProt | EBI | MGI Sequence Detail 233 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
Protein Ontology PR:000004689 B-cell lymphoma/leukemia 10
Graphical View of Protein Domain Structure
References
(Earliest) J:52071 Willis TG, et al., Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999 Jan 8;96(1):35-45
(Latest) J:196026 Van Beek M, et al., Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance. Cell Rep. 2012 May 31;1(5):444-52
All references(75)
Other
accession IDs
MGI:2139636, MGI:2140085

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory