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Bcl10 Gene Detail
Summary
  • Symbol
    Bcl10
  • Name
    B cell leukemia/lymphoma 10
  • Synonyms
    BCL-10, cE10, mE10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337994
    NCBI Gene: 12042
  • Gene Overview
    MyGene.info: BCL10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:145922804-145934356 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11553 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 71.03 cM, cytoband H3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BCL10, B cell CLL/lymphoma 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCL10, B cell CLL/lymphoma 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARMEN, c-E10, CIPER, CLAP, IMD37, mE10
  • Links
    NCBI Gene ID: 8915
    neXtProt AC: NX_O95999
    UniProt: O95999

  • Chr Location
    1p22.3; chr1:85265776-85276904 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human BCL10 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
About one-third of homozygous null embryos die exhibiting exencephaly. Surviving mutants display immunological defects including severe immunodeficiency, abnormal B cell development and function, and impaired humoral response to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000055197 VEGA Gene Model | MGI Sequence Detail 11553 C57BL/6J ±  kb
    transcript OTTMUST00000136703 VEGA | MGI Sequence Detail 1949 Not Applicable  
    polypeptide OTTMUSP00000072118 VEGA | MGI Sequence Detail 233 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      16 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 110

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139636, MGI:2140085
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 20
      Phenotypes 36
    • Earliest
      J:52071 Willis TG, et al., Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999 Jan 8;96(1):35-45
    • Latest
      J:235781 Nemeth T, et al., Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo. Nat Commun. 2016;7:11004

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory