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Bcl10 Gene Detail
Summary
  • Symbol
    Bcl10
  • Name
    B cell leukemia/lymphoma 10
  • Synonyms
    BCL-10, cE10, mE10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337994
    NCBI Gene: 12042
Location & Maps
more
  • Sequence Map
    Chr3:145922804-145934356 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11553 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BCL10, B-cell CLL/lymphoma 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCL10, B-cell CLL/lymphoma 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CARMEN, c-E10, CIPER, CLAP, IMD37, mE10
  • Links
    NCBI Gene ID: 8915
    neXtProt AC: NX_O95999

  • Chr Location
    1p22; chr1:85265776-85276904 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    6 with human BCL10 associations

Human Disease Mouse Models
       Follicular Lymphoma, Susceptibility to, 1; FL1   OMIM: 613024
Immunodeficiency 37; IMD37   OMIM: 616098
Lymphoma, Mucosa-Associated Lymphoid Type   OMIM: 137245
Lymphoma, Non-Hodgkin, Familial   OMIM: 605027
Mesothelioma, Malignant; MESOM   OMIM: 156240
Testicular Germ Cell Tumor; TGCT   OMIM: 273300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Bcl10
  • Incidental Mutations
About one-third of homozygous null embryos die exhibiting exencephaly. Surviving mutants display immunological defects including severe immunodeficiency, abnormal B cell development and function, and impaired humoral response to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055197 VEGA Gene Model | MGI Sequence Detail 11553 C57BL/6J ±  kb
transcript OTTMUST00000136703 VEGA | MGI Sequence Detail 1949 Not Applicable  
polypeptide OTTMUSP00000072118 VEGA | MGI Sequence Detail 233 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
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  • All nucleic 108
    cDNA 108

    Microarray probesets 6
Other
Accession IDs
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MGI:2139636, MGI:2140085
References
more
  • Summaries
    All 73
    Developmental Gene Expression 3
    Gene Ontology 19
    Phenotypes 31
  • Earliest
    J:52071 Willis TG, et al., Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999 Jan 8;96(1):35-45
  • Latest
    J:218677 Jia XM, et al., CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med. 2014 Oct 20;211(11):2307-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory