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Rev3l Gene Detail
Summary
  • Symbol
    Rev3l
  • Name
    REV3 like, DNA directed polymerase zeta catalytic subunit
  • Synonyms
    Rev, Sez4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337131
    NCBI Gene: 19714
  • Gene Overview
    MyGene.info: REV3L
Location & Maps
more
  • Sequence Map
    Chr10:39732118-39875211 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      143094 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    POLZ, REV3
  • Links
    NCBI Gene ID: 5980
    neXtProt AC: NX_O60673

  • Chr Location
    6q21; chr6:111299031-111483715 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 48147
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: REV3L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 7 alleles in 6 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    14
  • Radiation induced
    1
  • Targeted
    13
  • Genomic Mutations
    2 involving Rev3l
  • Incidental Mutations
Nullizygous mice exhibit complete embryonic lethality and abnormal embryonic tissue morphology with widespread degeneration and cell death. Mice carrying the amino acid substitution of phenylalanine for leucine at position 2610 display alterations in somatic hypermutation frequency and specificity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031765 VEGA Gene Model | MGI Sequence Detail 143094 C57BL/6J ±  kb
transcript OTTMUST00000078698 VEGA | MGI Sequence Detail 10713 Not Applicable  
polypeptide OTTMUSP00000041885 VEGA | MGI Sequence Detail 3122 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    505 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013900 DNA polymerase zeta catalytic subunit
  • PDB
  • EC
  • InterPro Domains
    IPR025687 C4-type zinc-finger of DNA polymerase delta
    IPR006172 DNA-directed DNA polymerase, family B
    IPR017964 DNA-directed DNA polymerase, family B, conserved site
    IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
    IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
    IPR023211 DNA polymerase, palm domain
    IPR030559 DNA polymerase zeta catalytic subunit
    IPR032757 Domain of unknown function DUF4683
    IPR012337 Ribonuclease H-like domain
Molecular
Reagents
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  • All nucleic 117
    Genomic 1
    cDNA 116

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-39490, MGI:109491
References
more
  • Summaries
    All 56
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:31864 Kajiwara K, et al., Molecular characterization of seizure-related genes isolated by differential screening. Biochem Biophys Res Commun. 1996 Feb 27;219(3):795-9
  • Latest
    J:223033 Tomas-Roca L, et al., De novo mutations in PLXND1 and REV3L cause Mobius syndrome. Nat Commun. 2015;6:7199

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory