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Rev3l Gene Detail
Summary
  • Symbol
    Rev3l
  • Name
    REV3 like, DNA directed polymerase zeta catalytic subunit
  • Synonyms
    Rev, Sez4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337131
    NCBI Gene: 19714
  • Gene Overview
    MyGene.info: REV3L
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:39732118-39875211 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 21.04 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337131
protein coding gene Chr10:39732069-39875211 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017153
protein coding gene Chr10:38255434-38401069 (+)
A/J MGP_AJ_G0017130
protein coding gene Chr10:37233266-37373085 (+)
AKR/J MGP_AKRJ_G0017090
protein coding gene Chr10:37751359-37893735 (+)
BALB/cJ MGP_BALBcJ_G0017093
protein coding gene Chr10:37277245-37439980 (+)
C3H/HeJ MGP_C3HHeJ_G0016913
protein coding gene Chr10:38078471-38221603 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017551
protein coding gene Chr10:39424620-39579179 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015248
protein coding gene Chr10:35216981-35366345 (+)
CAST/EiJ MGP_CASTEiJ_G0016492
protein coding gene Chr10:38238556-38391366 (+)
CBA/J MGP_CBAJ_G0016887
protein coding gene Chr10:41251091-41402299 (+)
DBA/2J MGP_DBA2J_G0016992
protein coding gene Chr10:36753742-36898022 (+)
FVB/NJ MGP_FVBNJ_G0016987
protein coding gene Chr10:36258459-36399532 (+)
LP/J MGP_LPJ_G0017069
protein coding gene Chr10:38227194-38374280 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017017
protein coding gene Chr10:42090955-42255812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017588
protein coding gene Chr10:37740237-37885153 (+)
PWK/PhJ MGP_PWKPhJ_G0016273
protein coding gene Chr10:36598112-36739541 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016057
protein coding gene Chr10:37538402-37682915 (+)
WSB/EiJ MGP_WSBEiJ_G0016555
protein coding gene Chr10:38016922-38164019 (+)



Homology
more
  • Human Ortholog
    REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    POLZ, REV3
  • Links
    NCBI Gene ID: 5980
    neXtProt AC: NX_O60673
    UniProt: O60673

  • Chr Location
    6q21; chr6:111299031-111483715 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 48147
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: REV3L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 9 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit complete embryonic lethality and abnormal embryonic tissue morphology with widespread degeneration and cell death. Mice carrying the amino acid substitution of phenylalanine for leucine at position 2610 display alterations in somatic hypermutation frequency and specificity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019841 Ensembl Gene Model | MGI Sequence Detail 143094 C57BL/6J ±  kb
    transcript ENSMUST00000019986 Ensembl | MGI Sequence Detail 10713 Not Applicable  
    polypeptide ENSMUSP00000019986 Ensembl | MGI Sequence Detail 3122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013900 DNA polymerase zeta catalytic subunit
    • PDB
    • EC
    • InterPro Domains
      IPR039225 AT-hook DNA-binding motif-containing protein 1
      IPR025687 C4-type zinc-finger of DNA polymerase delta
      IPR006172 DNA-directed DNA polymerase, family B
      IPR017964 DNA-directed DNA polymerase, family B, conserved site
      IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
      IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
      IPR023211 DNA polymerase, palm domain superfamily
      IPR030559 DNA polymerase zeta catalytic subunit
      IPR032757 Domain of unknown function DUF4683
      IPR012337 Ribonuclease H-like superfamily
      IPR036397 Ribonuclease H superfamily
    Molecular
    Reagents
    less
    • All nucleic 119
      Genomic 1
      cDNA 117
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39490, MGI:109491
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:232141 Lange SS, et al., The Polymerase Activity of Mammalian DNA Pol zeta Is Specifically Required for Cell and Embryonic Viability. PLoS Genet. 2016 Jan;12(1):e1005759

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory